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Illumina Body Map 2: averaged replicates
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Results for CEBPE_CEBPD
Z-value: 3.43
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Transcription factors associated with CEBPE_CEBPD
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPE | hg19_v2_chr14_-_23588816_23588836 | 0.20 | 2.8e-01 | Click! |
| CEBPD | hg19_v2_chr8_-_48651648_48651648 | 0.09 | 6.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPE_CEBPD
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 63.6 | GO:0006953 | acute-phase response(GO:0006953) |
| 2.6 | 46.3 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 6.1 | 42.8 | GO:0019557 | histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606) |
| 5.8 | 35.0 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.9 | 26.5 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 1.4 | 23.7 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 2.0 | 19.6 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.2 | 16.9 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 4.1 | 16.3 | GO:2001027 | negative regulation of endothelial cell chemotaxis(GO:2001027) |
| 0.5 | 15.8 | GO:0006825 | copper ion transport(GO:0006825) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 80.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 60.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.0 | 49.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.2 | 39.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 16.3 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.4 | 15.6 | GO:0036019 | endolysosome(GO:0036019) |
| 0.1 | 14.6 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 3.5 | 13.8 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 10.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 9.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.8 | 47.0 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.8 | 44.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 14.3 | 42.8 | GO:0004397 | histidine ammonia-lyase activity(GO:0004397) |
| 0.3 | 35.7 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.1 | 33.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 6.4 | 31.8 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.9 | 19.6 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 1.9 | 16.9 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.5 | 15.6 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 2.3 | 13.8 | GO:0030492 | hemoglobin binding(GO:0030492) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 35.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.8 | 34.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 16.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 14.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.3 | 14.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 14.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.4 | 13.5 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 12.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 10.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 9.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 49.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 37.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 2.1 | 31.8 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 1.2 | 30.8 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.5 | 27.1 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.8 | 27.0 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 20.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 19.2 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.3 | 16.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 15.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |