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Illumina Body Map 2: averaged replicates
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Results for CREB1
Z-value: 2.86
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Transcription factors associated with CREB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB1 | hg19_v2_chr2_+_208423891_208423950 | -0.34 | 5.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_113943447 Show fit | 4.41 |
ENST00000369425.1
ENST00000348367.4 ENST00000423155.1 |
glycerol-3-phosphate acyltransferase, mitochondrial |
|
| chr8_-_144623595 Show fit | 3.68 |
ENST00000262577.5
|
zinc finger CCCH-type containing 3 |
|
| chr22_+_26879817 Show fit | 3.51 |
ENST00000215917.7
|
SRR1 domain containing |
|
| chr16_+_19078911 Show fit | 3.45 |
ENST00000321998.5
|
coenzyme Q7 homolog, ubiquinone (yeast) |
|
| chr11_-_66112555 Show fit | 3.08 |
ENST00000425825.2
ENST00000359957.3 |
breast cancer metastasis suppressor 1 |
|
| chr12_-_132628847 Show fit | 3.05 |
ENST00000397333.3
|
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 |
|
| chr8_-_17104099 Show fit | 2.98 |
ENST00000524358.1
|
CCR4-NOT transcription complex, subunit 7 |
|
| chr3_+_128598433 Show fit | 2.57 |
ENST00000308982.7
ENST00000514336.1 |
acyl-CoA dehydrogenase family, member 9 |
|
| chr16_+_19078960 Show fit | 2.44 |
ENST00000568985.1
ENST00000566110.1 |
coenzyme Q7 homolog, ubiquinone (yeast) |
|
| chr11_-_126138808 Show fit | 2.42 |
ENST00000332118.6
ENST00000532259.1 |
signal recognition particle receptor (docking protein) |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 6.8 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 5.8 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.2 | 5.3 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.2 | 5.0 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.5 | 4.9 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.1 | 4.8 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.5 | 4.4 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.7 | 4.1 | GO:0061034 | olfactory bulb mitral cell layer development(GO:0061034) |
| 1.0 | 4.0 | GO:0009386 | translational attenuation(GO:0009386) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 6.5 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 6.5 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.9 | 6.2 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.0 | 5.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.2 | 5.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.3 | 5.0 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 4.8 | GO:0016235 | aggresome(GO:0016235) |
| 1.4 | 4.3 | GO:0075341 | host cell PML body(GO:0075341) |
| 0.0 | 4.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 5.6 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 5.6 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.0 | 5.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 4.8 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 4.5 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 1.5 | 4.4 | GO:0004366 | glycerol-3-phosphate O-acyltransferase activity(GO:0004366) |
| 0.2 | 4.3 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 4.3 | GO:0031491 | nucleosome binding(GO:0031491) |
| 1.1 | 4.2 | GO:0016426 | tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 3.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 3.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 1.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.2 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 1.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.6 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.2 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.3 | 4.7 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.2 | 4.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 4.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 4.4 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 4.3 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 3.9 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 3.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 3.4 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.1 | 3.3 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |