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Illumina Body Map 2: averaged replicates
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Results for CREB3L2
Z-value: 1.65
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Transcription factors associated with CREB3L2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB3L2 | hg19_v2_chr7_-_137686791_137686821 | -0.02 | 8.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_61584026 Show fit | 4.06 |
ENST00000370351.4
ENST00000370349.3 |
solute carrier family 17 (vesicular nucleotide transporter), member 9 |
|
| chr20_+_61584398 Show fit | 3.39 |
ENST00000411611.1
|
solute carrier family 17 (vesicular nucleotide transporter), member 9 |
|
| chr19_-_4670345 Show fit | 2.49 |
ENST00000599630.1
ENST00000262947.3 |
chromosome 19 open reading frame 10 |
|
| chr20_-_22559211 Show fit | 2.39 |
ENST00000564492.1
|
long intergenic non-protein coding RNA 261 |
|
| chr17_-_26695013 Show fit | 2.27 |
ENST00000555059.2
|
Homeobox protein SEBOX |
|
| chr17_-_26694979 Show fit | 2.06 |
ENST00000438614.1
|
vitronectin |
|
| chr9_+_96928516 Show fit | 1.83 |
ENST00000602703.1
|
RP11-2B6.3 |
|
| chr12_-_49318715 Show fit | 1.83 |
ENST00000444214.2
|
FK506 binding protein 11, 19 kDa |
|
| chr14_+_100789669 Show fit | 1.81 |
ENST00000361529.3
ENST00000557052.1 |
solute carrier family 25, member 47 |
|
| chr5_+_34656569 Show fit | 1.76 |
ENST00000428746.2
|
retinoic acid induced 14 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB3L2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | GO:1903146 | regulation of mitophagy(GO:1903146) |
| 0.8 | 3.3 | GO:1904806 | regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808) |
| 0.7 | 3.3 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.3 | 3.0 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.1 | 2.7 | GO:1903874 | ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874) |
| 0.1 | 2.7 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.0 | 2.7 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.4 | 2.5 | GO:2001274 | negative regulation of glucose import in response to insulin stimulus(GO:2001274) |
| 0.2 | 2.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.2 | 2.3 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 5.0 | GO:0031301 | integral component of organelle membrane(GO:0031301) |
| 0.0 | 3.1 | GO:0015030 | Cajal body(GO:0015030) |
| 1.0 | 3.0 | GO:0071748 | IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751) |
| 0.3 | 2.7 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 2.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.5 | 2.1 | GO:0071062 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.0 | 1.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.4 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 1.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 3.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 2.7 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.1 | 2.4 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.1 | 2.3 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 2.3 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 2.1 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 2.0 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.1 | 1.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 1.8 | GO:0015226 | amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.8 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.9 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.7 | PID EPHB FWD PATHWAY | EPHB forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 4.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 2.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 2.7 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 2.0 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 1.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.2 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 1.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |