ISMARA results: CXXC1

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Illumina Body Map 2: averaged replicates

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Results for CXXC1

Z-value: 2.12

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Transcription factors associated with CXXC1

Gene Symbol	Gene ID	Gene Info
CXXC1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000154832.10	CXXC finger protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CXXC1	hg19_v2_chr18_-_47813940_47814021	-0.27	1.3e-01	Click!

Activity profile of CXXC1 motif

Sorted Z-values of CXXC1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_183989157 Show fit	2.15	ENST00000541912.1	NUP35 Ensembl NCBI GeneCards UniProt NextProt Show fit	nucleoporin 35kDa
chr3_+_151531810 Show fit	1.61	ENST00000232892.7	AADAC Ensembl NCBI GeneCards UniProt NextProt Show fit	arylacetamide deacetylase
chr2_-_217560248 Show fit	1.61	ENST00000233813.4	IGFBP5 Ensembl NCBI GeneCards UniProt NextProt Show fit	insulin-like growth factor binding protein 5
chr6_-_46620522 Show fit	1.60	ENST00000275016.2	CYP39A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome P450, family 39, subfamily A, polypeptide 1
chr10_-_79397391 Show fit	1.55	ENST00000286628.8 ENST00000406533.3 ENST00000354353.5 ENST00000404857.1	KCNMA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr5_+_115298165 Show fit	1.53	ENST00000357872.4	AQPEP Ensembl NCBI GeneCards UniProt NextProt Show fit	Aminopeptidase Q
chr14_+_102027688 Show fit	1.47	ENST00000510508.4 ENST00000359323.3	DIO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	deiodinase, iodothyronine, type III
chr2_+_1488435 Show fit	1.40	ENST00000446278.1 ENST00000469607.1	TPO Ensembl NCBI GeneCards UniProt NextProt Show fit	thyroid peroxidase
chr5_+_115298145 Show fit	1.39	ENST00000395528.2	AQPEP Ensembl NCBI GeneCards UniProt NextProt Show fit	Aminopeptidase Q
chr3_+_151531859 Show fit	1.34	ENST00000488869.1	AADAC Ensembl NCBI GeneCards UniProt NextProt Show fit	arylacetamide deacetylase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CXXC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.6	GO:0034465	response to carbon monoxide(GO:0034465)
0.3	4.0	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.1	3.7	GO:0006999	nuclear pore organization(GO:0006999)
0.1	3.3	GO:1901998	toxin transport(GO:1901998)
0.2	3.2	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.0	2.9	GO:0007586	digestion(GO:0007586)
0.3	2.7	GO:0075509	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	2.7	GO:0070126	mitochondrial translational termination(GO:0070126)
0.5	2.6	GO:0030573	bile acid catabolic process(GO:0030573)
0.0	2.6	GO:0006635	fatty acid beta-oxidation(GO:0006635)

Showing 1 to 10 of 450 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	15.4	GO:0005759	mitochondrial matrix(GO:0005759)
0.0	8.5	GO:0019866	organelle inner membrane(GO:0019866)
0.0	4.4	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.2	3.9	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	3.0	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1	2.9	GO:0002080	acrosomal membrane(GO:0002080)
0.0	2.9	GO:0005581	collagen trimer(GO:0005581)
0.0	2.9	GO:0043296	apical junction complex(GO:0043296)
0.2	2.4	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
0.0	2.3	GO:0030496	midbody(GO:0030496)

Showing 1 to 10 of 162 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.8	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)
0.1	4.0	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.1	4.0	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	3.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2	2.8	GO:0019534	toxin transporter activity(GO:0019534)
0.0	2.8	GO:0003743	translation initiation factor activity(GO:0003743)
0.1	2.7	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	2.4	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	2.3	GO:0097110	scaffold protein binding(GO:0097110)
0.0	2.3	GO:0019213	deacetylase activity(GO:0019213)

Showing 1 to 10 of 326 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	2.8	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	2.7	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	2.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	2.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	2.1	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	1.9	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	1.8	PID FGF PATHWAY	FGF signaling pathway
0.0	1.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Showing 1 to 10 of 44 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.2	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0	3.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.0	3.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	3.2	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	3.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	2.9	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	2.8	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	2.7	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.1	2.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	2.4	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones

Showing 1 to 10 of 84 entries

Results for CXXC1

Z-value: 2.12

Motif logo

Transcription factors associated with CXXC1

Activity-expression correlation:

Activity profile of CXXC1 motif

Sorted Z-values of CXXC1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CXXC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: