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Illumina Body Map 2: averaged replicates

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Results for DLX3_EVX1_MEOX1

Z-value: 0.92

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Transcription factors associated with DLX3_EVX1_MEOX1

Gene Symbol Gene ID Gene Info
DLX3
ENSG00000064195.7 distal-less homeobox 3
EVX1
ENSG00000106038.8 even-skipped homeobox 1
MEOX1
ENSG00000005102.8 mesenchyme homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEOX1hg19_v2_chr17_-_41738931_417390400.212.4e-01Click!
EVX1hg19_v2_chr7_+_27282319_27282394-0.183.1e-01Click!
DLX3hg19_v2_chr17_-_48072574_480725970.048.1e-01Click!

Activity profile of DLX3_EVX1_MEOX1 motif

Sorted Z-values of DLX3_EVX1_MEOX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_6233828 1.40 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr4_-_36245561 1.38 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr14_+_22748980 1.37 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr5_-_115890554 1.34 ENST00000509665.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr7_-_111424462 1.18 ENST00000437129.1
DOCK4
dedicator of cytokinesis 4
chr13_+_58206655 1.17 ENST00000377918.3
PCDH17
protocadherin 17
chr6_+_151646800 1.14 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr4_-_138453606 1.09 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr7_-_111424506 1.07 ENST00000450156.1
ENST00000494651.2
DOCK4
dedicator of cytokinesis 4
chr18_-_53019208 1.05 ENST00000562607.1
TCF4
transcription factor 4
chr19_-_47137942 0.96 ENST00000300873.4
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr7_-_99716914 0.90 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr13_-_46716969 0.90 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_109541610 0.89 ENST00000510212.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr7_-_14029283 0.86 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr15_-_64673630 0.85 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr18_-_53255379 0.84 ENST00000565908.2
TCF4
transcription factor 4
chr10_-_56561022 0.81 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
PCDH15
protocadherin-related 15
chr3_+_111718036 0.77 ENST00000455401.2
TAGLN3
transgelin 3
chr15_-_55562479 0.76 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr3_+_111717600 0.74 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111717511 0.74 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr14_+_59100774 0.72 ENST00000556859.1
ENST00000421793.1
DACT1
dishevelled-binding antagonist of beta-catenin 1
chr7_+_80255472 0.71 ENST00000428497.1
CD36
CD36 molecule (thrombospondin receptor)
chr13_-_36788718 0.70 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr17_-_46716647 0.69 ENST00000608940.1
RP11-357H14.17
RP11-357H14.17
chr15_-_55562582 0.69 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chrX_+_99839799 0.65 ENST00000373031.4
TNMD
tenomodulin
chr8_-_82395461 0.65 ENST00000256104.4
FABP4
fatty acid binding protein 4, adipocyte
chr3_+_2933893 0.65 ENST00000397459.2
CNTN4
contactin 4
chr6_+_130339710 0.63 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr3_+_115342349 0.61 ENST00000393780.3
GAP43
growth associated protein 43
chrX_-_13835147 0.61 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr14_+_22739823 0.60 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr15_-_55563072 0.60 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr18_-_44181442 0.60 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr22_+_22930626 0.58 ENST00000390302.2
IGLV2-33
immunoglobulin lambda variable 2-33 (non-functional)
chr17_-_38928414 0.58 ENST00000335552.4
KRT26
keratin 26
chr13_+_110958124 0.58 ENST00000400163.2
COL4A2
collagen, type IV, alpha 2
chr7_-_14028488 0.57 ENST00000405358.4
ETV1
ets variant 1
chr14_-_36988882 0.55 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr1_-_157746909 0.55 ENST00000392274.3
ENST00000361516.3
ENST00000368181.4
FCRL2
Fc receptor-like 2
chrX_-_18690210 0.54 ENST00000379984.3
RS1
retinoschisin 1
chr7_-_83824449 0.53 ENST00000420047.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr16_+_14280564 0.53 ENST00000572567.1
MKL2
MKL/myocardin-like 2
chr7_+_80253387 0.52 ENST00000438020.1
CD36
CD36 molecule (thrombospondin receptor)
chr6_+_135502501 0.52 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr3_+_111718173 0.52 ENST00000494932.1
TAGLN3
transgelin 3
chr4_+_40198527 0.52 ENST00000381799.5
RHOH
ras homolog family member H
chr15_-_64673665 0.52 ENST00000300035.4
KIAA0101
KIAA0101
chr8_-_10512569 0.51 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr7_-_83824169 0.51 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr15_-_55562451 0.50 ENST00000568803.1
RAB27A
RAB27A, member RAS oncogene family
chr1_+_202317815 0.50 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr7_-_81399355 0.50 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr4_-_138453559 0.49 ENST00000511115.1
PCDH18
protocadherin 18
chr6_-_32157947 0.49 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr1_-_21625486 0.47 ENST00000481130.2
ECE1
endothelin converting enzyme 1
chr15_+_75080883 0.47 ENST00000567571.1
CSK
c-src tyrosine kinase
chr4_-_109541539 0.46 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr10_+_118187379 0.46 ENST00000369230.3
PNLIPRP3
pancreatic lipase-related protein 3
chr12_-_53045948 0.46 ENST00000309680.3
KRT2
keratin 2
chr2_-_224467093 0.45 ENST00000305409.2
SCG2
secretogranin II
chr20_+_45947246 0.44 ENST00000599904.1
AL031666.2
HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr10_-_73848086 0.43 ENST00000536168.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr2_+_7865923 0.43 ENST00000417930.1
AC092580.4
AC092580.4
chr3_-_3151664 0.42 ENST00000256452.3
ENST00000311981.8
ENST00000430514.2
ENST00000456302.1
IL5RA
interleukin 5 receptor, alpha
chr12_-_52995291 0.41 ENST00000293745.2
ENST00000354310.4
KRT72
keratin 72
chr5_-_141249154 0.41 ENST00000357517.5
ENST00000536585.1
PCDH1
protocadherin 1
chr5_+_173930676 0.41 ENST00000504512.1
RP11-267A15.1
RP11-267A15.1
chr13_-_28545276 0.41 ENST00000381020.7
CDX2
caudal type homeobox 2
chr2_+_169757750 0.40 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
G6PC2
glucose-6-phosphatase, catalytic, 2
chr7_-_27169801 0.40 ENST00000511914.1
HOXA4
homeobox A4
chr2_+_196313239 0.40 ENST00000413290.1
AC064834.1
AC064834.1
chrX_+_135730297 0.40 ENST00000370629.2
CD40LG
CD40 ligand
chr1_+_198608146 0.38 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_-_232651312 0.38 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr6_+_127898312 0.38 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr4_-_25865159 0.38 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr11_-_33913708 0.37 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_160370344 0.36 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr2_-_224467002 0.36 ENST00000421386.1
ENST00000433889.1
SCG2
secretogranin II
chr7_+_129906660 0.36 ENST00000222481.4
CPA2
carboxypeptidase A2 (pancreatic)
chr11_+_128563652 0.35 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr6_-_116833500 0.35 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr6_+_126221034 0.35 ENST00000433571.1
NCOA7
nuclear receptor coactivator 7
chr1_-_183622442 0.34 ENST00000308641.4
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr13_-_30683005 0.34 ENST00000413591.1
ENST00000432770.1
LINC00365
long intergenic non-protein coding RNA 365
chr7_+_99717230 0.34 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr9_-_75488984 0.34 ENST00000423171.1
ENST00000449235.1
ENST00000453787.1
RP11-151D14.1
RP11-151D14.1
chr11_-_40315640 0.34 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr3_+_2553281 0.33 ENST00000434053.1
CNTN4
contactin 4
chr7_-_81399438 0.33 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_83278322 0.32 ENST00000307792.3
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr11_-_107729887 0.32 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr2_-_145188137 0.32 ENST00000440875.1
ZEB2
zinc finger E-box binding homeobox 2
chr14_+_97925151 0.32 ENST00000554862.1
ENST00000554260.1
ENST00000499910.2
CTD-2506J14.1
CTD-2506J14.1
chr6_-_76203454 0.31 ENST00000237172.7
FILIP1
filamin A interacting protein 1
chr3_+_44840679 0.31 ENST00000425755.1
KIF15
kinesin family member 15
chr6_-_138866823 0.30 ENST00000342260.5
NHSL1
NHS-like 1
chr14_-_95236551 0.30 ENST00000238558.3
GSC
goosecoid homeobox
chr11_+_115498761 0.30 ENST00000424313.2
AP000997.1
AP000997.1
chr6_-_116866773 0.29 ENST00000368602.3
TRAPPC3L
trafficking protein particle complex 3-like
chrX_-_100129128 0.29 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr12_+_15699286 0.29 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr6_+_46761118 0.28 ENST00000230588.4
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr1_+_198608292 0.28 ENST00000418674.1
PTPRC
protein tyrosine phosphatase, receptor type, C
chr7_-_81399329 0.28 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr1_+_107683436 0.28 ENST00000370068.1
NTNG1
netrin G1
chr11_-_107729287 0.28 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr12_-_89746264 0.28 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chr11_-_107729504 0.28 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr3_-_123339343 0.28 ENST00000578202.1
MYLK
myosin light chain kinase
chrX_+_78426469 0.27 ENST00000276077.1
GPR174
G protein-coupled receptor 174
chr14_-_92247032 0.27 ENST00000556661.1
ENST00000553676.1
ENST00000554560.1
CATSPERB
catsper channel auxiliary subunit beta
chr1_+_198607801 0.27 ENST00000367379.1
PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_-_176812842 0.27 ENST00000507540.1
GPM6A
glycoprotein M6A
chr15_-_31393910 0.27 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr3_-_108248169 0.27 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr6_-_31107127 0.26 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr12_-_68619586 0.26 ENST00000229134.4
IL26
interleukin 26
chr2_-_203735484 0.26 ENST00000420558.1
ENST00000418208.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr11_-_117748138 0.26 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chr14_+_62585332 0.25 ENST00000554895.1
LINC00643
long intergenic non-protein coding RNA 643
chr12_-_89746173 0.25 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr7_+_50348268 0.25 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr11_-_117747607 0.25 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chr11_-_117747434 0.24 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr1_+_107683644 0.24 ENST00000370067.1
NTNG1
netrin G1
chr7_-_81399411 0.23 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_100860851 0.23 ENST00000223127.3
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr7_-_14029515 0.23 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ETV1
ets variant 1
chr12_+_8666126 0.23 ENST00000299665.2
CLEC4D
C-type lectin domain family 4, member D
chr3_+_77088989 0.23 ENST00000461745.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr3_+_155755482 0.23 ENST00000472028.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr2_+_158114051 0.23 ENST00000259056.4
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr14_+_22180536 0.23 ENST00000390424.2
TRAV2
T cell receptor alpha variable 2
chr5_-_34043310 0.22 ENST00000231338.7
C1QTNF3
C1q and tumor necrosis factor related protein 3
chr19_-_7968427 0.22 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr12_-_94673956 0.22 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr16_+_14280742 0.22 ENST00000341243.5
MKL2
MKL/myocardin-like 2
chr13_-_30160925 0.22 ENST00000450494.1
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr10_-_56560939 0.22 ENST00000373955.1
PCDH15
protocadherin-related 15
chr19_-_4902877 0.21 ENST00000381781.2
ARRDC5
arrestin domain containing 5
chr4_-_120243545 0.21 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr4_-_46126093 0.21 ENST00000295452.4
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr2_-_99279928 0.21 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr17_-_54893250 0.21 ENST00000397862.2
C17orf67
chromosome 17 open reading frame 67
chr16_-_67517716 0.20 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr18_-_56985776 0.20 ENST00000587244.1
CPLX4
complexin 4
chr4_-_87028478 0.20 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr14_+_22564294 0.19 ENST00000390452.2
TRDV1
T cell receptor delta variable 1
chr17_-_57229155 0.19 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr3_-_195538760 0.19 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr1_+_111415757 0.19 ENST00000429072.2
ENST00000271324.5
CD53
CD53 molecule
chr15_+_80351910 0.19 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr1_+_50575292 0.19 ENST00000371821.1
ENST00000371819.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr8_+_70404996 0.18 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr12_-_14133053 0.18 ENST00000609686.1
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr14_-_69261310 0.18 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr15_-_37393406 0.18 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr4_-_66536057 0.18 ENST00000273854.3
EPHA5
EPH receptor A5
chr14_+_101359265 0.18 ENST00000599197.1
AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr3_-_100565249 0.18 ENST00000495591.1
ENST00000383691.4
ENST00000466947.1
ABI3BP
ABI family, member 3 (NESH) binding protein
chr19_+_50016610 0.18 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr4_-_48683188 0.18 ENST00000505759.1
FRYL
FRY-like
chrX_-_110655306 0.18 ENST00000371993.2
DCX
doublecortin
chr20_+_3776371 0.18 ENST00000245960.5
CDC25B
cell division cycle 25B
chr11_-_67220200 0.18 ENST00000312457.2
GPR152
G protein-coupled receptor 152
chr6_+_43968306 0.17 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr3_-_195538728 0.17 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr11_+_101918153 0.17 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
C11orf70
chromosome 11 open reading frame 70
chrX_-_19689106 0.17 ENST00000379716.1
SH3KBP1
SH3-domain kinase binding protein 1
chr9_+_116225999 0.17 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr3_+_185431080 0.17 ENST00000296270.1
C3orf65
chromosome 3 open reading frame 65
chr17_-_39140549 0.17 ENST00000377755.4
KRT40
keratin 40
chr7_+_37723336 0.17 ENST00000450180.1
GPR141
G protein-coupled receptor 141
chr11_+_67219867 0.16 ENST00000438189.2
CABP4
calcium binding protein 4
chr14_-_78083112 0.16 ENST00000216484.2
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr10_+_114710425 0.16 ENST00000352065.5
ENST00000369395.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr20_+_42523336 0.16 ENST00000428529.1
RP5-1030M6.3
RP5-1030M6.3
chr14_+_56584414 0.16 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr6_+_167536230 0.15 ENST00000341935.5
ENST00000349984.4
CCR6
chemokine (C-C motif) receptor 6
chr1_-_197115818 0.15 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr7_+_129984630 0.15 ENST00000355388.3
ENST00000497503.1
ENST00000463587.1
ENST00000461828.1
ENST00000494311.1
ENST00000466363.2
ENST00000485477.1
ENST00000431780.2
ENST00000474905.1
CPA5
carboxypeptidase A5
chr10_-_105845674 0.15 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr10_-_23633720 0.15 ENST00000323327.4
C10orf67
chromosome 10 open reading frame 67
chr11_-_118083600 0.15 ENST00000524477.1
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr15_+_96869165 0.15 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr5_+_66300446 0.15 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr8_-_101963482 0.15 ENST00000419477.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr3_+_152879985 0.15 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family
chr3_-_143567262 0.14 ENST00000474151.1
ENST00000316549.6
SLC9A9
solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
chr14_+_100485712 0.14 ENST00000544450.2
EVL
Enah/Vasp-like
chr2_+_219135115 0.14 ENST00000248451.3
ENST00000273077.4
PNKD
paroxysmal nonkinesigenic dyskinesia
chr12_-_120241187 0.14 ENST00000392520.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr17_-_48133054 0.14 ENST00000499842.1
RP11-1094H24.4
RP11-1094H24.4
chr12_+_41831485 0.14 ENST00000539469.2
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4
chr2_-_214016314 0.14 ENST00000434687.1
ENST00000374319.4
IKZF2
IKAROS family zinc finger 2 (Helios)
chr17_+_59489112 0.14 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX3_EVX1_MEOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:1990709 presynaptic active zone organization(GO:1990709)
0.4 2.5 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.3 2.3 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.3 1.0 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.2 0.9 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.2 0.5 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.5 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.4 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.0 GO:0019236 response to pheromone(GO:0019236)
0.1 1.5 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.5 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.7 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.1 1.2 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.3 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.3 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 1.0 GO:0050957 equilibrioception(GO:0050957)
0.1 0.7 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1 0.4 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 1.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.5 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.1 0.3 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.1 0.8 GO:0016198 axon choice point recognition(GO:0016198)
0.1 0.2 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 1.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.2 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.6 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.2 GO:0006667 sphinganine metabolic process(GO:0006667)
0.1 0.6 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.5 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1 0.2 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.8 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 0.1 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 1.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.4 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 1.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.6 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 1.0 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.1 GO:0048631 negative regulation of skeletal muscle cell proliferation(GO:0014859) regulation of skeletal muscle tissue growth(GO:0048631) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.5 GO:0051546 keratinocyte migration(GO:0051546)
0.0 0.4 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.5 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.2 GO:0044334 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.2 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.1 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.0 0.2 GO:0071638 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.1 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.1 GO:2000691 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.2 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.0 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.3 GO:0014820 tonic smooth muscle contraction(GO:0014820)
0.0 0.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.2 GO:0060539 diaphragm development(GO:0060539)
0.0 1.0 GO:0042461 photoreceptor cell development(GO:0042461)
0.0 0.4 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.3 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.1 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0035627 ceramide transport(GO:0035627)
0.0 0.4 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.4 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.2 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.0 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.1 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.4 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.1 0.3 GO:0005873 plus-end kinesin complex(GO:0005873)
0.1 0.3 GO:0035841 new growing cell tip(GO:0035841)
0.1 0.6 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 0.6 GO:0032584 growth cone membrane(GO:0032584)
0.1 3.9 GO:0032420 stereocilium(GO:0032420)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.0 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.7 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.0 1.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0036128 CatSper complex(GO:0036128)
0.0 0.8 GO:0031045 dense core granule(GO:0031045)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0031265 death-inducing signaling complex(GO:0031264) CD95 death-inducing signaling complex(GO:0031265)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 1.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.4 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 1.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.4 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 2.5 GO:0031489 myosin V binding(GO:0031489)
0.1 0.7 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.4 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.1 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
0.1 0.6 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 1.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 2.4 GO:0042056 chemoattractant activity(GO:0042056)
0.0 1.6 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.6 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 2.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.1 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.1 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.8 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.4 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.4 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.6 PID CD40 PATHWAY CD40/CD40L signaling
0.0 2.2 PID PDGFRB PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.9 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 3.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation