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Illumina Body Map 2: averaged replicates

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Results for DMC1

Z-value: 1.10

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966123_389661630.173.6e-01Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_69865866 3.94 ENST00000354393.2
MYPN
myopalladin
chr5_+_94727048 2.43 ENST00000283357.5
FAM81B
family with sequence similarity 81, member B
chr7_-_150884332 2.04 ENST00000275838.1
ENST00000422024.1
ENST00000434669.1
ASB10
ankyrin repeat and SOCS box containing 10
chr2_-_75788038 1.99 ENST00000393913.3
ENST00000410113.1
EVA1A
eva-1 homolog A (C. elegans)
chr20_+_123010 1.91 ENST00000382398.3
DEFB126
defensin, beta 126
chr1_+_166958346 1.80 ENST00000367872.4
MAEL
maelstrom spermatogenic transposon silencer
chr3_+_148457585 1.77 ENST00000402260.1
AGTR1
angiotensin II receptor, type 1
chr2_+_171640291 1.71 ENST00000409885.1
ERICH2
glutamate-rich 2
chr2_+_120187465 1.69 ENST00000409826.1
ENST00000417645.1
TMEM37
transmembrane protein 37
chr1_+_166958497 1.69 ENST00000367870.2
MAEL
maelstrom spermatogenic transposon silencer
chr6_+_46661575 1.67 ENST00000450697.1
TDRD6
tudor domain containing 6
chr12_-_9268707 1.56 ENST00000318602.7
A2M
alpha-2-macroglobulin
chr1_+_166958504 1.54 ENST00000447624.1
MAEL
maelstrom spermatogenic transposon silencer
chrX_-_49965009 1.51 ENST00000437370.1
ENST00000376064.3
ENST00000448865.1
AKAP4
A kinase (PRKA) anchor protein 4
chr10_-_104597286 1.45 ENST00000369887.3
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chrX_-_63450480 1.43 ENST00000362002.2
ASB12
ankyrin repeat and SOCS box containing 12
chr10_+_17851362 1.41 ENST00000331429.2
ENST00000457317.1
MRC1L1
cDNA FLJ56855, highly similar to Macrophage mannose receptor 1
chr17_+_31318886 1.34 ENST00000269053.3
ENST00000394638.1
SPACA3
sperm acrosome associated 3
chrX_-_49965663 1.34 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
AKAP4
A kinase (PRKA) anchor protein 4
chr15_-_42448788 1.33 ENST00000382396.4
ENST00000397272.3
PLA2G4F
phospholipase A2, group IVF
chr11_+_71238313 1.26 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr3_-_108672609 1.23 ENST00000393963.3
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chr12_-_9268819 1.19 ENST00000404455.2
A2M
alpha-2-macroglobulin
chr2_+_187454749 1.17 ENST00000261023.3
ENST00000374907.3
ITGAV
integrin, alpha V
chr3_-_108672742 1.11 ENST00000261047.3
GUCA1C
guanylate cyclase activator 1C
chr5_+_79615790 1.10 ENST00000296739.4
SPZ1
spermatogenic leucine zipper 1
chr7_-_15601595 1.10 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr9_-_34729457 1.08 ENST00000378788.3
FAM205A
family with sequence similarity 205, member A
chr20_+_2796948 1.03 ENST00000361033.1
ENST00000380585.1
TMEM239
transmembrane protein 239
chr5_-_36301984 1.03 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RANBP3L
RAN binding protein 3-like
chr12_-_71031185 1.01 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB
protein tyrosine phosphatase, receptor type, B
chr15_-_61945400 1.00 ENST00000560686.1
RP11-507B12.1
RP11-507B12.1
chr12_-_71031220 0.93 ENST00000334414.6
PTPRB
protein tyrosine phosphatase, receptor type, B
chr2_-_48982708 0.91 ENST00000428232.1
ENST00000405626.1
ENST00000294954.7
LHCGR
luteinizing hormone/choriogonadotropin receptor
chrX_-_134305322 0.88 ENST00000276241.6
ENST00000344129.2
CXorf48
cancer/testis antigen 55
chr17_+_77018896 0.81 ENST00000578229.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr7_-_150884873 0.79 ENST00000377867.3
ASB10
ankyrin repeat and SOCS box containing 10
chr17_+_77019030 0.75 ENST00000580454.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr2_+_201173667 0.72 ENST00000409755.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr2_-_48982857 0.68 ENST00000403273.1
ENST00000401907.1
ENST00000344775.3
LHCGR
luteinizing hormone/choriogonadotropin receptor
chr10_-_135187193 0.67 ENST00000368547.3
ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chr1_-_160924589 0.66 ENST00000368029.3
ITLN2
intelectin 2
chr12_-_120805872 0.63 ENST00000546985.1
MSI1
musashi RNA-binding protein 1
chr14_+_74318611 0.60 ENST00000555976.1
ENST00000267568.4
PTGR2
prostaglandin reductase 2
chr22_+_21133469 0.60 ENST00000406799.1
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr6_+_88054530 0.60 ENST00000388923.4
C6orf163
chromosome 6 open reading frame 163
chr14_+_74318513 0.58 ENST00000555228.1
ENST00000555661.1
PTGR2
prostaglandin reductase 2
chr2_-_18741882 0.56 ENST00000381249.3
RDH14
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chr3_-_141747950 0.54 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr3_-_141747459 0.52 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr10_+_62538248 0.47 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr10_+_62538089 0.47 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr10_+_74870206 0.45 ENST00000357321.4
ENST00000349051.5
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr2_-_190044480 0.43 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr10_+_74870253 0.42 ENST00000544879.1
ENST00000537969.1
ENST00000372997.3
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr5_-_82969405 0.40 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr3_-_99569821 0.38 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr8_+_67104940 0.37 ENST00000517689.1
LINC00967
long intergenic non-protein coding RNA 967
chr11_-_73720122 0.36 ENST00000426995.2
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr19_-_42947121 0.35 ENST00000601181.1
CXCL17
chemokine (C-X-C motif) ligand 17
chr1_+_18958008 0.34 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chr5_-_82969363 0.34 ENST00000503117.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr20_-_21378666 0.33 ENST00000351817.4
NKX2-4
NK2 homeobox 4
chr1_-_247876105 0.33 ENST00000302084.2
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr4_-_76944621 0.31 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr1_-_47131521 0.31 ENST00000542495.1
ENST00000532925.1
ATPAF1
ATP synthase mitochondrial F1 complex assembly factor 1
chr2_+_233497931 0.31 ENST00000264059.3
EFHD1
EF-hand domain family, member D1
chr2_-_197675000 0.30 ENST00000342506.2
C2orf66
chromosome 2 open reading frame 66
chr11_-_73720276 0.28 ENST00000348534.4
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr10_-_98031155 0.28 ENST00000495266.1
BLNK
B-cell linker
chr7_-_6010263 0.27 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr1_-_190446759 0.26 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr7_+_6793740 0.25 ENST00000403107.1
ENST00000404077.1
ENST00000435395.1
ENST00000418406.1
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chr21_-_35281399 0.25 ENST00000418933.1
ATP5O
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr10_-_98031310 0.24 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr4_+_2800722 0.22 ENST00000508385.1
SH3BP2
SH3-domain binding protein 2
chr12_-_53901266 0.22 ENST00000609999.1
ENST00000267017.3
NPFF
neuropeptide FF-amide peptide precursor
chr10_-_62332357 0.21 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr14_+_21525981 0.19 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr3_+_9944303 0.19 ENST00000421412.1
ENST00000295980.3
IL17RE
interleukin 17 receptor E
chr14_-_21491477 0.19 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
NDRG2
NDRG family member 2
chr17_-_42875115 0.19 ENST00000591137.1
CTC-296K1.4
CTC-296K1.4
chr14_+_21492331 0.18 ENST00000533984.1
ENST00000532213.2
AL161668.5
AL161668.5
chr1_+_1222489 0.15 ENST00000379099.3
SCNN1D
sodium channel, non-voltage-gated 1, delta subunit
chr10_-_98031265 0.15 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr4_+_106473768 0.14 ENST00000265154.2
ENST00000420470.2
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38
chr17_-_60142609 0.12 ENST00000397786.2
MED13
mediator complex subunit 13
chr2_-_61244550 0.12 ENST00000421319.1
PUS10
pseudouridylate synthase 10
chr10_-_74856608 0.11 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr1_-_111061797 0.10 ENST00000369771.2
KCNA10
potassium voltage-gated channel, shaker-related subfamily, member 10
chr11_-_85780086 0.10 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr18_+_56892724 0.09 ENST00000456142.3
ENST00000530323.1
GRP
gastrin-releasing peptide
chr19_+_11466062 0.08 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr20_+_11008408 0.07 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr2_+_61244697 0.07 ENST00000401576.1
ENST00000295030.5
ENST00000414712.2
PEX13
peroxisomal biogenesis factor 13
chr2_-_31637560 0.06 ENST00000379416.3
XDH
xanthine dehydrogenase
chr14_-_21492251 0.06 ENST00000554398.1
NDRG2
NDRG family member 2
chr21_+_31802572 0.02 ENST00000334068.2
KRTAP13-4
keratin associated protein 13-4
chr7_+_150758642 0.01 ENST00000488420.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr7_+_150758304 0.01 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
SLC4A2
solute carrier family 4 (anion exchanger), member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.5 1.6 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.4 1.8 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.3 1.2 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.2 1.6 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.2 5.0 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 1.3 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.2 3.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 2.3 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.1 0.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.9 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.1 1.0 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 1.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.6 GO:0008218 bioluminescence(GO:0008218)
0.1 2.6 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.3 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1 1.4 GO:0006702 androgen biosynthetic process(GO:0006702)
0.1 1.3 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0 0.2 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.2 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.2 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.6 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 1.2 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 1.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.1 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.0 0.1 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 0.4 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.9 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.1 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.6 GO:0042572 retinol metabolic process(GO:0042572)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.0 GO:0030849 autosome(GO:0030849)
0.4 1.2 GO:0034685 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
0.2 2.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 0.9 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.7 GO:0033391 chromatoid body(GO:0033391)
0.1 2.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.3 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 2.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 4.2 GO:0030018 Z disc(GO:0030018)
0.0 1.3 GO:0045095 keratin filament(GO:0045095)
0.0 1.6 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.4 1.6 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.4 2.8 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.3 2.3 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.2 1.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.2 1.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 1.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 3.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 1.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 0.6 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 1.3 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 1.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 1.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.7 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.9 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 2.9 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 1.6 GO:0005518 collagen binding(GO:0005518)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID CONE PATHWAY Visual signal transduction: Cones
0.1 0.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 3.4 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.4 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 1.6 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 1.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 0.9 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.9 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.7 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.7 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling