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Illumina Body Map 2: averaged replicates
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Results for DUXA
Z-value: 1.88
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Transcription factors associated with DUXA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DUXA | hg19_v2_chr19_-_57678811_57678811 | -0.05 | 7.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_175629164 Show fit | 7.49 |
ENST00000409323.1
ENST00000261007.5 ENST00000348749.5 |
cholinergic receptor, nicotinic, alpha 1 (muscle) |
|
| chr16_+_6533729 Show fit | 5.22 |
ENST00000551752.1
|
RNA binding protein, fox-1 homolog (C. elegans) 1 |
|
| chr2_-_175629135 Show fit | 3.71 |
ENST00000409542.1
ENST00000409219.1 |
cholinergic receptor, nicotinic, alpha 1 (muscle) |
|
| chr10_-_69425399 Show fit | 3.55 |
ENST00000330298.6
|
catenin (cadherin-associated protein), alpha 3 |
|
| chr16_+_6533380 Show fit | 3.54 |
ENST00000552089.1
|
RNA binding protein, fox-1 homolog (C. elegans) 1 |
|
| chr5_+_173472607 Show fit | 3.53 |
ENST00000303177.3
ENST00000519867.1 |
Neuron-specific protein family member 2 |
|
| chr11_-_16419067 Show fit | 3.53 |
ENST00000533411.1
|
SRY (sex determining region Y)-box 6 |
|
| chr4_-_46126093 Show fit | 3.38 |
ENST00000295452.4
|
gamma-aminobutyric acid (GABA) A receptor, gamma 1 |
|
| chr10_+_69865866 Show fit | 3.24 |
ENST00000354393.2
|
myopalladin |
|
| chr7_+_54398390 Show fit | 3.23 |
ENST00000458615.1
ENST00000426205.1 |
RP11-436F9.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DUXA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 11.2 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.1 | 7.5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.3 | 6.8 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.8 | 5.0 | GO:0021779 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 0.1 | 4.0 | GO:0060080 | inhibitory postsynaptic potential(GO:0060080) |
| 0.0 | 3.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 3.6 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.1 | 3.6 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.3 | 3.5 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.1 | 3.1 | GO:0048268 | clathrin coat assembly(GO:0048268) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.2 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 10.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 5.6 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 4.6 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 4.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 4.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 3.7 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.2 | 3.5 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 3.5 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 3.5 | GO:0032585 | multivesicular body membrane(GO:0032585) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.9 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.4 | 11.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 5.3 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 4.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.2 | 4.4 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 3.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 3.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 3.5 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.3 | 3.5 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.1 | 3.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 6.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 2.4 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 2.3 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 2.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 11.2 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 4.8 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.1 | 4.4 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 3.5 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 3.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.9 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 1.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.7 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 1.5 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |