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Illumina Body Map 2: averaged replicates
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Results for E2F2_E2F5
Z-value: 1.90
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Transcription factors associated with E2F2_E2F5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F2 | hg19_v2_chr1_-_23857698_23857733 | 0.69 | 1.3e-05 | Click! |
| E2F5 | hg19_v2_chr8_+_86089619_86089653 | 0.41 | 2.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F2_E2F5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.5 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 1.4 | 7.1 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 0.5 | 6.3 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.1 | 6.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 5.7 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.4 | 5.0 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.2 | 4.4 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.3 | 3.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 1.2 | 3.6 | GO:1990426 | homologous recombination-dependent replication fork processing(GO:1990426) |
| 0.5 | 3.6 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.7 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 5.8 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 5.6 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 5.6 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 5.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.2 | 3.6 | GO:0000800 | lateral element(GO:0000800) |
| 0.2 | 3.2 | GO:0071439 | clathrin complex(GO:0071439) |
| 1.0 | 2.9 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.0 | 2.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.7 | 2.6 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.7 | 5.6 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.0 | 5.1 | GO:0001047 | core promoter binding(GO:0001047) |
| 1.7 | 5.0 | GO:0015633 | zinc transporting ATPase activity(GO:0015633) |
| 0.0 | 4.8 | GO:0004386 | helicase activity(GO:0004386) |
| 0.6 | 4.4 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.0 | 4.1 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.2 | 3.3 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 3.2 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.2 | 3.1 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 7.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 7.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 5.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 3.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.8 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.1 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.5 | 8.2 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 5.0 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 5.0 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 4.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.2 | 4.2 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 4.0 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.2 | 3.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 2.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.6 | REACTOME KINESINS | Genes involved in Kinesins |