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Illumina Body Map 2: averaged replicates

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Results for E2F4

Z-value: 0.96

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Transcription factors associated with E2F4

Gene Symbol Gene ID Gene Info
E2F4
ENSG00000205250.4 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F4hg19_v2_chr16_+_67226019_672261270.291.1e-01Click!

Activity profile of E2F4 motif

Sorted Z-values of E2F4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_45810594 1.34 ENST00000177694.1
TBX21
T-box 21
chr17_+_38444115 1.28 ENST00000580824.1
ENST00000577249.1
CDC6
cell division cycle 6
chrY_+_22737604 1.27 ENST00000361365.2
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chrY_+_22737678 1.20 ENST00000382772.3
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr4_-_185655212 1.03 ENST00000541971.1
MLF1IP
centromere protein U
chr19_+_16187085 1.02 ENST00000300933.4
TPM4
tropomyosin 4
chr2_-_136875712 1.00 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chr17_+_77751931 0.99 ENST00000310942.4
ENST00000269399.5
CBX2
chromobox homolog 2
chr20_+_42295745 0.99 ENST00000396863.4
ENST00000217026.4
MYBL2
v-myb avian myeloblastosis viral oncogene homolog-like 2
chr14_-_94856951 0.96 ENST00000553327.1
ENST00000556955.1
ENST00000557118.1
ENST00000440909.1
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_94857004 0.95 ENST00000557492.1
ENST00000448921.1
ENST00000437397.1
ENST00000355814.4
ENST00000393088.4
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_126661253 0.95 ENST00000368326.1
ENST00000368325.1
ENST00000368328.4
CENPW
centromere protein W
chr6_+_391739 0.94 ENST00000380956.4
IRF4
interferon regulatory factor 4
chr14_-_94856987 0.94 ENST00000449399.3
ENST00000404814.4
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_55658323 0.92 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr2_+_10263298 0.90 ENST00000474701.1
RRM2
ribonucleotide reductase M2
chr6_+_135502501 0.89 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr9_-_21994344 0.89 ENST00000530628.2
ENST00000361570.3
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr6_+_31865552 0.86 ENST00000469372.1
ENST00000497706.1
C2
complement component 2
chr5_-_127873659 0.84 ENST00000262464.4
FBN2
fibrillin 2
chr15_+_91260552 0.81 ENST00000355112.3
ENST00000560509.1
BLM
Bloom syndrome, RecQ helicase-like
chr19_+_18284477 0.79 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr11_+_45944190 0.79 ENST00000401752.1
ENST00000389968.3
ENST00000325468.5
ENST00000536139.1
GYLTL1B
glycosyltransferase-like 1B
chr12_-_77459306 0.77 ENST00000547316.1
ENST00000416496.2
ENST00000550669.1
ENST00000322886.7
E2F7
E2F transcription factor 7
chr6_+_45389893 0.74 ENST00000371432.3
RUNX2
runt-related transcription factor 2
chr8_-_67525473 0.72 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr8_-_67525524 0.72 ENST00000517885.1
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr19_+_797443 0.71 ENST00000394601.4
ENST00000589575.1
PTBP1
polypyrimidine tract binding protein 1
chr12_+_49717019 0.70 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
TROAP
trophinin associated protein
chr16_-_8962853 0.69 ENST00000565287.1
ENST00000311052.5
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr7_-_27135591 0.69 ENST00000343060.4
ENST00000355633.5
HOXA1
homeobox A1
chr16_-_8962544 0.68 ENST00000570125.1
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr22_+_31892261 0.67 ENST00000432498.1
ENST00000540643.1
ENST00000443326.1
ENST00000414585.1
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr3_+_32280159 0.67 ENST00000458535.2
ENST00000307526.3
CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr11_-_61129723 0.66 ENST00000537680.1
ENST00000426130.2
ENST00000294072.4
CYB561A3
cytochrome b561 family, member A3
chr16_+_67678818 0.65 ENST00000334583.6
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr1_+_28844778 0.64 ENST00000411533.1
RCC1
regulator of chromosome condensation 1
chr22_+_19467261 0.64 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
CDC45
cell division cycle 45
chr22_+_46972975 0.63 ENST00000431155.1
GRAMD4
GRAM domain containing 4
chr2_+_10262857 0.61 ENST00000304567.5
RRM2
ribonucleotide reductase M2
chr9_-_110251836 0.61 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr2_+_232573208 0.60 ENST00000409115.3
PTMA
prothymosin, alpha
chr4_+_74702214 0.60 ENST00000226317.5
ENST00000515050.1
CXCL6
chemokine (C-X-C motif) ligand 6
chrX_-_131623874 0.60 ENST00000436215.1
MBNL3
muscleblind-like splicing regulator 3
chr9_-_136857403 0.59 ENST00000406606.3
ENST00000371850.3
VAV2
vav 2 guanine nucleotide exchange factor
chr5_+_118604385 0.59 ENST00000274456.6
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chrX_-_131623982 0.58 ENST00000370844.1
MBNL3
muscleblind-like splicing regulator 3
chr5_+_109025067 0.58 ENST00000261483.4
MAN2A1
mannosidase, alpha, class 2A, member 1
chr1_+_113217345 0.58 ENST00000357443.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr19_+_797392 0.57 ENST00000350092.4
ENST00000349038.4
ENST00000586481.1
ENST00000585535.1
PTBP1
polypyrimidine tract binding protein 1
chr16_+_67679069 0.57 ENST00000545661.1
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chrX_+_30671476 0.56 ENST00000378946.3
ENST00000378943.3
ENST00000378945.3
ENST00000427190.1
ENST00000378941.3
GK
glycerol kinase
chr8_+_124084899 0.55 ENST00000287380.1
ENST00000309336.3
ENST00000519418.1
ENST00000327098.5
ENST00000522420.1
ENST00000521676.1
ENST00000378080.2
TBC1D31
TBC1 domain family, member 31
chr20_+_37554955 0.55 ENST00000217429.4
FAM83D
family with sequence similarity 83, member D
chr16_+_11439286 0.55 ENST00000312499.5
ENST00000576027.1
RMI2
RecQ mediated genome instability 2
chr10_+_120967072 0.55 ENST00000392870.2
GRK5
G protein-coupled receptor kinase 5
chr19_-_42894420 0.54 ENST00000597255.1
ENST00000222032.5
CNFN
cornifelin
chr1_+_113217309 0.54 ENST00000544796.1
ENST00000369644.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr4_-_185655278 0.53 ENST00000281453.5
MLF1IP
centromere protein U
chr8_-_17103951 0.53 ENST00000520178.1
CNOT7
CCR4-NOT transcription complex, subunit 7
chr6_+_135502466 0.53 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr1_-_182922505 0.53 ENST00000367547.3
SHCBP1L
SHC SH2-domain binding protein 1-like
chr1_+_28844648 0.52 ENST00000373832.1
ENST00000373831.3
RCC1
regulator of chromosome condensation 1
chr14_+_50065376 0.52 ENST00000298288.6
LRR1
leucine rich repeat protein 1
chr2_-_20424844 0.52 ENST00000403076.1
ENST00000254351.4
SDC1
syndecan 1
chr3_+_10068095 0.52 ENST00000287647.3
ENST00000383807.1
ENST00000383806.1
ENST00000419585.1
FANCD2
Fanconi anemia, complementation group D2
chr12_-_53574671 0.51 ENST00000444623.1
CSAD
cysteine sulfinic acid decarboxylase
chr12_+_49717081 0.51 ENST00000547807.1
ENST00000551567.1
TROAP
trophinin associated protein
chr22_-_42310570 0.51 ENST00000457093.1
SHISA8
shisa family member 8
chr1_+_173837488 0.49 ENST00000427304.1
ENST00000432989.1
ENST00000367702.1
ZBTB37
zinc finger and BTB domain containing 37
chrX_-_14891150 0.49 ENST00000452869.1
ENST00000398334.1
ENST00000324138.3
FANCB
Fanconi anemia, complementation group B
chr8_+_128748466 0.49 ENST00000524013.1
ENST00000520751.1
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr9_-_21994597 0.46 ENST00000579755.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr14_+_50065459 0.46 ENST00000318317.4
LRR1
leucine rich repeat protein 1
chr5_+_14664762 0.46 ENST00000284274.4
FAM105B
family with sequence similarity 105, member B
chr19_-_10444188 0.46 ENST00000293677.6
RAVER1
ribonucleoprotein, PTB-binding 1
chrX_-_153095945 0.45 ENST00000164640.4
PDZD4
PDZ domain containing 4
chr1_+_91966656 0.45 ENST00000428239.1
ENST00000426137.1
CDC7
cell division cycle 7
chr13_+_32889605 0.45 ENST00000380152.3
ENST00000544455.1
ENST00000530893.2
BRCA2
breast cancer 2, early onset
chr1_+_91966384 0.44 ENST00000430031.2
ENST00000234626.6
CDC7
cell division cycle 7
chr8_-_124408652 0.44 ENST00000287394.5
ATAD2
ATPase family, AAA domain containing 2
chr7_+_100199800 0.44 ENST00000223061.5
PCOLCE
procollagen C-endopeptidase enhancer
chr8_+_128748308 0.44 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr14_-_74959978 0.44 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr3_-_53080047 0.44 ENST00000482396.1
ENST00000358080.2
ENST00000296295.6
ENST00000394752.3
SFMBT1
Scm-like with four mbt domains 1
chr19_-_10679644 0.43 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr9_+_131709966 0.43 ENST00000372577.2
NUP188
nucleoporin 188kDa
chr7_-_139876734 0.42 ENST00000006967.5
JHDM1D
lysine (K)-specific demethylase 7A
chr1_-_229761717 0.42 ENST00000366675.3
ENST00000258281.2
ENST00000366674.1
TAF5L
TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr8_-_101157680 0.42 ENST00000428847.2
FBXO43
F-box protein 43
chr21_-_33651324 0.42 ENST00000290130.3
MIS18A
MIS18 kinetochore protein A
chr11_+_82612740 0.42 ENST00000524921.1
ENST00000528759.1
ENST00000525361.1
ENST00000430323.2
ENST00000533655.1
ENST00000532764.1
ENST00000532589.1
ENST00000525388.1
C11orf82
chromosome 11 open reading frame 82
chr1_-_226496898 0.42 ENST00000481685.1
LIN9
lin-9 homolog (C. elegans)
chr19_+_14017116 0.42 ENST00000589606.1
CC2D1A
coiled-coil and C2 domain containing 1A
chr5_+_55033845 0.41 ENST00000353507.5
ENST00000514278.2
ENST00000505374.1
ENST00000506511.1
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr7_-_100034060 0.41 ENST00000292330.2
PPP1R35
protein phosphatase 1, regulatory subunit 35
chr9_-_98079965 0.40 ENST00000289081.3
FANCC
Fanconi anemia, complementation group C
chr7_-_86849883 0.40 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr4_+_128802016 0.40 ENST00000270861.5
ENST00000515069.1
ENST00000513090.1
ENST00000507249.1
PLK4
polo-like kinase 4
chr16_+_29817399 0.40 ENST00000545521.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr4_+_56815102 0.40 ENST00000257287.4
CEP135
centrosomal protein 135kDa
chr16_+_50776021 0.39 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr4_-_119757322 0.39 ENST00000379735.5
SEC24D
SEC24 family member D
chr12_+_53574464 0.39 ENST00000416904.3
ZNF740
zinc finger protein 740
chr10_+_112257596 0.39 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr17_-_43339453 0.39 ENST00000543122.1
SPATA32
spermatogenesis associated 32
chr22_+_20105012 0.38 ENST00000331821.3
ENST00000411892.1
RANBP1
RAN binding protein 1
chr15_+_90744745 0.38 ENST00000558051.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr8_-_60031762 0.38 ENST00000361421.1
TOX
thymocyte selection-associated high mobility group box
chr19_-_19754404 0.38 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GMIP
GEM interacting protein
chr14_-_74960030 0.38 ENST00000553490.1
ENST00000557510.1
NPC2
Niemann-Pick disease, type C2
chr4_+_166794862 0.38 ENST00000513213.1
TLL1
tolloid-like 1
chr4_+_166128836 0.38 ENST00000511305.1
KLHL2
kelch-like family member 2
chr17_+_3572087 0.38 ENST00000248378.5
ENST00000397133.2
EMC6
ER membrane protein complex subunit 6
chr16_-_30064244 0.37 ENST00000571269.1
ENST00000561666.1
FAM57B
family with sequence similarity 57, member B
chr14_-_74959994 0.37 ENST00000238633.2
ENST00000434013.2
NPC2
Niemann-Pick disease, type C2
chr11_-_118972575 0.37 ENST00000432443.2
DPAGT1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chrX_-_153363125 0.37 ENST00000407218.1
ENST00000453960.2
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr19_-_19754354 0.37 ENST00000587238.1
GMIP
GEM interacting protein
chr11_+_32914579 0.37 ENST00000399302.2
QSER1
glutamine and serine rich 1
chr1_-_236030216 0.37 ENST00000389794.3
ENST00000389793.2
LYST
lysosomal trafficking regulator
chr17_-_3571934 0.37 ENST00000225525.3
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr18_+_66382428 0.36 ENST00000578970.1
ENST00000582371.1
ENST00000584775.1
CCDC102B
coiled-coil domain containing 102B
chr12_-_48499826 0.36 ENST00000551798.1
SENP1
SUMO1/sentrin specific peptidase 1
chr7_-_100026280 0.36 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr19_-_10679697 0.36 ENST00000335766.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr19_+_36208877 0.35 ENST00000420124.1
ENST00000222270.7
ENST00000341701.1
KMT2B
Histone-lysine N-methyltransferase 2B
chr11_-_93276514 0.35 ENST00000526869.1
SMCO4
single-pass membrane protein with coiled-coil domains 4
chr18_+_77623668 0.35 ENST00000316249.3
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr6_+_135502408 0.34 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr9_-_139304979 0.34 ENST00000357365.3
ENST00000371723.4
SDCCAG3
serologically defined colon cancer antigen 3
chr9_+_139886846 0.34 ENST00000371620.3
C9orf142
chromosome 9 open reading frame 142
chr15_+_45248880 0.34 ENST00000340827.3
C15orf43
chromosome 15 open reading frame 43
chr4_-_2264015 0.34 ENST00000337190.2
MXD4
MAX dimerization protein 4
chr4_+_331619 0.33 ENST00000505939.1
ENST00000240499.7
ZNF141
zinc finger protein 141
chr7_-_86849836 0.33 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr15_-_50647370 0.33 ENST00000558970.1
ENST00000396464.3
ENST00000560825.1
GABPB1
GA binding protein transcription factor, beta subunit 1
chr4_+_1714548 0.33 ENST00000605571.1
RP11-572O17.1
RP11-572O17.1
chr6_+_89790459 0.33 ENST00000369472.1
PNRC1
proline-rich nuclear receptor coactivator 1
chrX_-_153095813 0.33 ENST00000544474.1
PDZD4
PDZ domain containing 4
chr1_+_154475446 0.33 ENST00000368480.3
TDRD10
tudor domain containing 10
chr6_-_27114577 0.33 ENST00000356950.1
ENST00000396891.4
HIST1H2BK
histone cluster 1, H2bk
chr15_+_89631647 0.32 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr6_+_89790490 0.32 ENST00000336032.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr4_-_185395191 0.32 ENST00000510814.1
ENST00000507523.1
ENST00000506230.1
IRF2
interferon regulatory factor 2
chr4_-_157892498 0.32 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr12_+_110437328 0.32 ENST00000261739.4
ANKRD13A
ankyrin repeat domain 13A
chrX_-_19002696 0.31 ENST00000379942.4
PHKA2
phosphorylase kinase, alpha 2 (liver)
chr16_+_50775971 0.31 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
CYLD
cylindromatosis (turban tumor syndrome)
chr1_+_60280458 0.31 ENST00000455990.1
ENST00000371208.3
HOOK1
hook microtubule-tethering protein 1
chr15_-_50647347 0.31 ENST00000220429.8
ENST00000429662.2
GABPB1
GA binding protein transcription factor, beta subunit 1
chr1_-_197115818 0.31 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr12_+_112451120 0.31 ENST00000261735.3
ENST00000455836.1
ERP29
endoplasmic reticulum protein 29
chr8_-_101322132 0.31 ENST00000523481.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr2_+_47168313 0.31 ENST00000319190.5
ENST00000394850.2
ENST00000536057.1
TTC7A
tetratricopeptide repeat domain 7A
chr12_-_121734489 0.31 ENST00000412367.2
ENST00000402834.4
ENST00000404169.3
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr16_-_2264779 0.31 ENST00000333503.7
PGP
phosphoglycolate phosphatase
chr16_+_50775948 0.31 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
CYLD
cylindromatosis (turban tumor syndrome)
chr1_-_935491 0.31 ENST00000304952.6
HES4
hes family bHLH transcription factor 4
chr6_+_27775899 0.30 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr5_-_158636512 0.30 ENST00000424310.2
RNF145
ring finger protein 145
chr5_+_118604439 0.30 ENST00000388882.5
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr12_+_56521840 0.30 ENST00000394048.5
ESYT1
extended synaptotagmin-like protein 1
chr3_-_52719912 0.30 ENST00000420148.1
PBRM1
polybromo 1
chr11_-_72853267 0.30 ENST00000409418.4
FCHSD2
FCH and double SH3 domains 2
chr19_+_49468558 0.30 ENST00000331825.6
FTL
ferritin, light polypeptide
chrX_-_130037162 0.29 ENST00000432489.1
ENOX2
ecto-NOX disulfide-thiol exchanger 2
chr11_+_17298543 0.29 ENST00000533926.1
NUCB2
nucleobindin 2
chr7_-_139876812 0.29 ENST00000397560.2
JHDM1D
lysine (K)-specific demethylase 7A
chr11_+_17298255 0.29 ENST00000531172.1
ENST00000533738.2
ENST00000323688.6
NUCB2
nucleobindin 2
chr11_+_58910295 0.29 ENST00000420244.1
FAM111A
family with sequence similarity 111, member A
chr15_-_40401062 0.29 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
BMF
Bcl2 modifying factor
chr2_-_37551846 0.29 ENST00000443187.1
PRKD3
protein kinase D3
chr12_-_48499591 0.29 ENST00000551330.1
ENST00000004980.5
ENST00000339976.6
ENST00000448372.1
SENP1
SUMO1/sentrin specific peptidase 1
chr22_-_42342692 0.29 ENST00000404067.1
ENST00000402338.1
CENPM
centromere protein M
chr1_-_8939265 0.29 ENST00000489867.1
ENO1
enolase 1, (alpha)
chr14_+_105219437 0.29 ENST00000329967.6
ENST00000347067.5
ENST00000553810.1
SIVA1
SIVA1, apoptosis-inducing factor
chr19_+_11546440 0.29 ENST00000589126.1
ENST00000588269.1
ENST00000587509.1
ENST00000592741.1
ENST00000593101.1
ENST00000587327.1
PRKCSH
protein kinase C substrate 80K-H
chr4_-_1713977 0.29 ENST00000318386.4
SLBP
stem-loop binding protein
chr16_-_838329 0.29 ENST00000563560.1
ENST00000569601.1
ENST00000565809.1
ENST00000565377.1
ENST00000007264.2
ENST00000567114.1
RPUSD1
RNA pseudouridylate synthase domain containing 1
chr16_+_68119440 0.29 ENST00000346183.3
ENST00000329524.4
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chrX_+_109245863 0.28 ENST00000372072.3
TMEM164
transmembrane protein 164
chr11_+_17298297 0.28 ENST00000529010.1
NUCB2
nucleobindin 2
chr1_+_179262905 0.28 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr4_-_1714037 0.28 ENST00000488267.1
ENST00000429429.2
ENST00000480936.1
SLBP
stem-loop binding protein
chr19_-_31840130 0.28 ENST00000558569.1
TSHZ3
teashirt zinc finger homeobox 3
chr6_+_31707725 0.28 ENST00000375755.3
ENST00000375742.3
ENST00000375750.3
ENST00000425703.1
ENST00000534153.4
ENST00000375703.3
ENST00000375740.3
MSH5
mutS homolog 5
chr11_+_17298522 0.28 ENST00000529313.1
NUCB2
nucleobindin 2
chr7_-_150779995 0.28 ENST00000462940.1
ENST00000492838.1
ENST00000392818.3
ENST00000488752.1
ENST00000476627.1
TMUB1
transmembrane and ubiquitin-like domain containing 1
chr20_+_2082494 0.28 ENST00000246032.3
STK35
serine/threonine kinase 35
chr7_+_45039783 0.27 ENST00000258781.6
ENST00000541586.1
ENST00000544363.1
CCM2
cerebral cavernous malformation 2
chr4_-_157892167 0.27 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr12_-_53574376 0.27 ENST00000267085.4
ENST00000379850.3
ENST00000379846.1
ENST00000424990.1
CSAD
cysteine sulfinic acid decarboxylase
chr6_-_137113604 0.27 ENST00000359015.4
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr1_-_935361 0.27 ENST00000484667.2
HES4
hes family bHLH transcription factor 4
chr2_+_12858355 0.27 ENST00000405331.3
TRIB2
tribbles pseudokinase 2
chr20_+_1875378 0.27 ENST00000356025.3
SIRPA
signal-regulatory protein alpha
chr16_+_28834531 0.27 ENST00000570200.1
ATXN2L
ataxin 2-like
chr1_-_11741155 0.26 ENST00000445656.1
ENST00000376669.5
ENST00000456915.1
ENST00000376692.4
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr15_+_40987661 0.26 ENST00000526763.1
RAD51
RAD51 recombinase

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.3 1.0 GO:1990108 protein linear deubiquitination(GO:1990108)
0.3 1.3 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.3 0.9 GO:1990426 homologous recombination-dependent replication fork processing(GO:1990426)
0.3 0.9 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.3 0.9 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.3 1.3 GO:0042412 taurine biosynthetic process(GO:0042412)
0.2 0.9 GO:0090096 regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.2 0.6 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2 0.2 GO:1904976 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.2 1.2 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.2 0.6 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
0.2 0.5 GO:0048627 myoblast development(GO:0048627)
0.2 0.6 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.2 0.5 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.1 0.9 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.9 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.1 0.4 GO:1903461 Okazaki fragment processing involved in mitotic DNA replication(GO:1903461)
0.1 0.9 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.4 GO:0009405 pathogenesis(GO:0009405)
0.1 0.4 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 1.4 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.1 1.0 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1 0.5 GO:0043335 protein unfolding(GO:0043335)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.7 GO:0002254 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.1 1.1 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.6 GO:0097021 lymphocyte migration into lymphoid organs(GO:0097021)
0.1 0.3 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.2 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.1 0.2 GO:0071140 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.1 0.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 0.3 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.1 1.0 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.8 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 0.7 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.1 0.2 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.1 0.2 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.1 0.7 GO:0023035 CD40 signaling pathway(GO:0023035)
0.1 2.7 GO:0051290 protein heterotetramerization(GO:0051290)
0.1 0.8 GO:0048102 autophagic cell death(GO:0048102)
0.1 0.6 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.3 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.3 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 1.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.4 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 0.6 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.4 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.1 0.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.5 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 1.1 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.3 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.1 0.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.4 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 0.6 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.7 GO:0048752 cranial nerve formation(GO:0021603) semicircular canal morphogenesis(GO:0048752)
0.0 0.3 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.4 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.0 0.9 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.7 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.3 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0 0.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.7 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.2 GO:0044691 tooth eruption(GO:0044691)
0.0 0.2 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.0 0.1 GO:0072034 renal vesicle induction(GO:0072034)
0.0 0.3 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.2 GO:1902534 single-organism membrane invagination(GO:1902534)
0.0 0.2 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.3 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 1.1 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 2.9 GO:0006953 acute-phase response(GO:0006953)
0.0 0.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187)
0.0 0.2 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 0.2 GO:0032079 positive regulation of endodeoxyribonuclease activity(GO:0032079) positive regulation of phospholipid catabolic process(GO:0060697)
0.0 0.3 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.2 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 0.2 GO:0051383 kinetochore organization(GO:0051383)
0.0 1.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.3 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.5 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.5 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.0 0.7 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0045144 meiotic sister chromatid segregation(GO:0045144)
0.0 0.2 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.0 0.2 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185) recognition of apoptotic cell(GO:0043654)
0.0 0.1 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.3 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.5 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.6 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.2 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.5 GO:0048511 rhythmic process(GO:0048511)
0.0 0.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.2 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.2 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.4 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.1 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.1 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.0 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.4 GO:0001967 suckling behavior(GO:0001967)
0.0 0.3 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.2 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.1 GO:0046465 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.0 0.2 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.1 GO:1990869 apolipoprotein A-I-mediated signaling pathway(GO:0038027) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.3 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.4 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.0 0.2 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.3 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 0.3 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.4 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.0 0.3 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.1 GO:0061739 protein lipidation involved in autophagosome assembly(GO:0061739)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 1.0 GO:0043525 positive regulation of neuron apoptotic process(GO:0043525)
0.0 0.0 GO:1902559 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)
0.0 0.1 GO:0040031 snRNA modification(GO:0040031)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.6 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0006710 androgen catabolic process(GO:0006710)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.3 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 0.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.0 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.4 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.8 GO:0050919 negative chemotaxis(GO:0050919)
0.0 1.0 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.3 GO:0050900 leukocyte migration(GO:0050900)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0035608 protein deglutamylation(GO:0035608)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0031523 Myb complex(GO:0031523)
0.2 0.7 GO:0075341 host cell PML body(GO:0075341)
0.2 0.6 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.2 1.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.3 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 1.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.8 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 1.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.4 GO:1903349 omegasome membrane(GO:1903349)
0.1 0.6 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 1.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 1.3 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.8 GO:0072687 meiotic spindle(GO:0072687)
0.1 0.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.4 GO:0098536 deuterosome(GO:0098536)
0.1 0.6 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 0.3 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 0.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.2 GO:0005584 collagen type I trimer(GO:0005584)
0.1 1.2 GO:0000800 lateral element(GO:0000800)
0.0 1.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.4 GO:0071547 piP-body(GO:0071547)
0.0 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:0030426 growth cone(GO:0030426)
0.0 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0097196 Shu complex(GO:0097196)
0.0 0.3 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.8 GO:0005938 cell cortex(GO:0005938)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.5 GO:0070187 telosome(GO:0070187)
0.0 0.5 GO:0030914 STAGA complex(GO:0030914)
0.0 2.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.4 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 1.0 GO:0051233 spindle midzone(GO:0051233)
0.0 0.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.2 GO:0008278 cohesin complex(GO:0008278)
0.0 0.1 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.5 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.8 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.2 GO:0000796 condensin complex(GO:0000796)
0.0 1.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.2 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 2.5 GO:0043202 lysosomal lumen(GO:0043202)
0.0 2.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 1.3 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.2 0.6 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.2 1.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 0.6 GO:0004370 glycerol kinase activity(GO:0004370)
0.2 0.5 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.1 1.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.6 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.1 0.3 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.1 0.6 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.8 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 2.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.4 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 0.8 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 0.3 GO:0005018 platelet-derived growth factor alpha-receptor activity(GO:0005018)
0.1 0.6 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 1.0 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.4 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 1.1 GO:0032027 myosin light chain binding(GO:0032027)
0.1 0.3 GO:0003896 DNA primase activity(GO:0003896)
0.1 0.2 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.1 0.2 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.1 0.6 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.9 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 0.3 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1 0.2 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.3 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.4 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.2 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.2 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.2 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0 0.2 GO:0004797 thymidine kinase activity(GO:0004797)
0.0 0.4 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.4 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 1.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 1.0 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 0.9 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 3.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 1.3 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 1.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.1 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.0 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.9 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.3 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.1 GO:0016416 O-palmitoyltransferase activity(GO:0016416)
0.0 0.0 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 5.5 PID E2F PATHWAY E2F transcription factor network
0.0 1.3 PID IL27 PATHWAY IL27-mediated signaling events
0.0 2.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.5 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 2.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.0 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 1.4 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.9 PID AURORA A PATHWAY Aurora A signaling
0.0 0.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.8 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.3 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 3.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 0.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 0.3 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 1.1 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 2.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 2.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.7 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.0 0.2 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.5 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.8 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)