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Illumina Body Map 2: averaged replicates
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Results for E2F6
Z-value: 2.30
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Transcription factors associated with E2F6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F6 | hg19_v2_chr2_-_11605966_11606005 | 0.27 | 1.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_95653427 Show fit | 4.54 |
ENST00000454170.2
|
epithelial splicing regulatory protein 1 |
|
| chr8_+_95653373 Show fit | 4.00 |
ENST00000358397.5
|
epithelial splicing regulatory protein 1 |
|
| chr20_+_44098346 Show fit | 3.77 |
ENST00000372676.3
|
WAP four-disulfide core domain 2 |
|
| chr20_+_44098385 Show fit | 3.68 |
ENST00000217425.5
ENST00000339946.3 |
WAP four-disulfide core domain 2 |
|
| chr12_+_58005204 Show fit | 3.52 |
ENST00000286494.4
|
Rho guanine nucleotide exchange factor (GEF) 25 |
|
| chr8_+_95653302 Show fit | 3.33 |
ENST00000423620.2
ENST00000433389.2 |
epithelial splicing regulatory protein 1 |
|
| chr11_+_46402583 Show fit | 3.15 |
ENST00000359803.3
|
midkine (neurite growth-promoting factor 2) |
|
| chr21_+_47401650 Show fit | 2.74 |
ENST00000361866.3
|
collagen, type VI, alpha 1 |
|
| chrX_-_133119476 Show fit | 2.70 |
ENST00000543339.1
|
glypican 3 |
|
| chrX_-_128788914 Show fit | 2.62 |
ENST00000429967.1
ENST00000307484.6 |
apelin |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 9.6 | GO:0030421 | defecation(GO:0030421) |
| 0.1 | 8.8 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 1.0 | 6.1 | GO:0061364 | apoptotic process involved in luteolysis(GO:0061364) |
| 0.9 | 6.0 | GO:0072180 | mesonephric duct morphogenesis(GO:0072180) |
| 0.1 | 5.3 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.2 | 5.2 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 1.0 | 5.0 | GO:0048749 | compound eye development(GO:0048749) |
| 0.2 | 5.0 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 1.5 | 4.5 | GO:1901254 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 0.9 | 4.5 | GO:0003409 | optic cup structural organization(GO:0003409) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 21.5 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 19.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 9.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 8.9 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.3 | 8.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 8.7 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 8.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 6.9 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 6.9 | GO:0043296 | apical junction complex(GO:0043296) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.3 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.6 | 11.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 11.2 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.1 | 11.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 9.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 7.3 | GO:0008017 | microtubule binding(GO:0008017) |
| 1.2 | 7.0 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.2 | 6.4 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.0 | 6.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 6.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 23.2 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.3 | 18.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 18.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 10.8 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 9.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 9.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 6.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 5.6 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.2 | 5.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.6 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.4 | 13.3 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 6.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 5.3 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 5.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 5.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 4.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 4.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.2 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 4.0 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |