ISMARA results: E2F8

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Illumina Body Map 2: averaged replicates

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Results for E2F8

Z-value: 1.46

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Transcription factors associated with E2F8

Gene Symbol	Gene ID	Gene Info
E2F8 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000129173.8	E2F transcription factor 8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F8	hg19_v2_chr11_-_19263145_19263176	0.67	2.4e-05	Click!

Activity profile of E2F8 motif

Sorted Z-values of E2F8 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_24346218 Show fit	3.54	ENST00000436622.1 ENST00000313213.4	PFN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	profilin family, member 4
chr1_+_152850787 Show fit	3.19	ENST00000368765.3	SMCP Ensembl NCBI GeneCards UniProt NextProt Show fit	sperm mitochondria-associated cysteine-rich protein
chr2_+_79252804 Show fit	2.87	ENST00000393897.2	REG3G Ensembl NCBI GeneCards UniProt NextProt Show fit	regenerating islet-derived 3 gamma
chr2_-_198650037 Show fit	2.84	ENST00000392296.4	BOLL Ensembl NCBI GeneCards UniProt NextProt Show fit	boule-like RNA-binding protein
chr13_-_19755975 Show fit	2.83	ENST00000400113.3	TUBA3C Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulin, alpha 3c
chr2_+_79252822 Show fit	2.81	ENST00000272324.5	REG3G Ensembl NCBI GeneCards UniProt NextProt Show fit	regenerating islet-derived 3 gamma
chr2_-_152589670 Show fit	2.80	ENST00000604864.1 ENST00000603639.1	NEB Ensembl NCBI GeneCards UniProt NextProt Show fit	nebulin
chr2_-_130956006 Show fit	2.59	ENST00000312988.7	TUBA3E Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulin, alpha 3e
chr2_+_132233664 Show fit	2.39	ENST00000321253.6	TUBA3D Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulin, alpha 3d
chr16_-_34740829 Show fit	2.31	ENST00000562591.1	RP11-80F22.15 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-80F22.15

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	7.9	GO:0044278	cell wall disruption in other organism(GO:0044278)
0.3	4.3	GO:0042989	sequestering of actin monomers(GO:0042989)
0.2	4.0	GO:0090220	chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
1.2	3.7	GO:0060629	regulation of homologous chromosome segregation(GO:0060629)
0.6	3.4	GO:0093001	glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.4	3.2	GO:0007341	penetration of zona pellucida(GO:0007341)
0.6	2.8	GO:0007525	somatic muscle development(GO:0007525)
0.1	2.8	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1	2.6	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	2.2	GO:0007339	binding of sperm to zona pellucida(GO:0007339)

Showing 1 to 10 of 106 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.9	GO:0000795	synaptonemal complex(GO:0000795)
0.3	3.5	GO:0072687	meiotic spindle(GO:0072687)
0.4	3.4	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.1	2.9	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	2.8	GO:0030018	Z disc(GO:0030018)
0.0	2.4	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.5	1.9	GO:0005873	plus-end kinesin complex(GO:0005873)
0.1	1.9	GO:0035686	sperm fibrous sheath(GO:0035686)
0.1	1.8	GO:0042555	MCM complex(GO:0042555)
0.6	1.7	GO:0036387	nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)

Showing 1 to 10 of 54 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.9	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	7.0	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	6.6	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	3.5	GO:0070840	dynein complex binding(GO:0070840)
0.1	3.5	GO:0003785	actin monomer binding(GO:0003785)
0.3	3.4	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.1	2.8	GO:0008494	translation activator activity(GO:0008494)
0.0	2.8	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	2.7	GO:0003688	DNA replication origin binding(GO:0003688)
0.2	2.6	GO:0008429	phosphatidylethanolamine binding(GO:0008429)

Showing 1 to 10 of 86 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	2.6	PID NOTCH PATHWAY	Notch signaling pathway
0.0	2.5	PID ATR PATHWAY	ATR signaling pathway
0.0	2.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	2.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	1.5	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	1.4	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	1.3	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	1.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	1.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.2	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2	3.6	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	3.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	2.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	2.6	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	1.9	REACTOME KINESINS	Genes involved in Kinesins
0.1	1.5	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	1.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	1.1	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	0.9	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand

Showing 1 to 10 of 27 entries

Results for E2F8

Z-value: 1.46

Motif logo

Transcription factors associated with E2F8

Activity-expression correlation:

Activity profile of E2F8 motif

Sorted Z-values of E2F8 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: