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Illumina Body Map 2: averaged replicates
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Results for EBF3
Z-value: 1.79
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Transcription factors associated with EBF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EBF3 | hg19_v2_chr10_-_131762105_131762105 | 0.27 | 1.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106816253 Show fit | 3.85 |
ENST00000390615.2
|
immunoglobulin heavy variable 3-33 |
|
| chr12_+_57388230 Show fit | 3.52 |
ENST00000300098.1
|
G protein-coupled receptor 182 |
|
| chr14_-_106791536 Show fit | 3.46 |
ENST00000390613.2
|
immunoglobulin heavy variable 3-30 |
|
| chr2_+_89986318 Show fit | 3.28 |
ENST00000491977.1
|
immunoglobulin kappa variable 2D-29 |
|
| chr4_+_42399856 Show fit | 2.86 |
ENST00000319234.4
|
shisa family member 3 |
|
| chr3_-_142608001 Show fit | 2.85 |
ENST00000295992.3
|
procollagen C-endopeptidase enhancer 2 |
|
| chr22_+_23222886 Show fit | 2.77 |
ENST00000390319.2
|
immunoglobulin lambda variable 3-1 |
|
| chr14_-_106725723 Show fit | 2.66 |
ENST00000390609.2
|
immunoglobulin heavy variable 3-23 |
|
| chr14_-_106994333 Show fit | 2.56 |
ENST00000390624.2
|
immunoglobulin heavy variable 3-48 |
|
| chr3_-_142607740 Show fit | 2.52 |
ENST00000485766.1
|
procollagen C-endopeptidase enhancer 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 8.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 6.1 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.7 | 5.4 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.0 | 5.4 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.0 | 5.0 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.2 | 4.6 | GO:0036376 | sodium ion export from cell(GO:0036376) |
| 0.9 | 4.5 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 1.3 | 4.0 | GO:0060621 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 0.4 | 3.9 | GO:0021564 | vagus nerve development(GO:0021564) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.0 | GO:0016459 | myosin complex(GO:0016459) |
| 0.2 | 9.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 6.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.8 | 5.4 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.0 | 5.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 4.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 4.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 4.6 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 4.6 | GO:0000791 | euchromatin(GO:0000791) |
| 0.0 | 4.2 | GO:0072562 | blood microparticle(GO:0072562) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 13.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 9.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 4.6 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.0 | 4.4 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 4.2 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 1.0 | 4.0 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.0 | 3.7 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 1.2 | 3.6 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.4 | 2.7 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 5.9 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 4.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 4.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 3.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 2.7 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 2.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 5.2 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.2 | 4.9 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 4.2 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 3.4 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 3.4 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.1 | 3.0 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 2.7 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 2.7 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.2 | 2.3 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |