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Illumina Body Map 2: averaged replicates

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Results for EN2_GBX2_LBX2

Z-value: 0.99

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Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol Gene ID Gene Info
EN2
ENSG00000164778.4 engrailed homeobox 2
GBX2
ENSG00000168505.6 gastrulation brain homeobox 2
LBX2
ENSG00000179528.11 ladybird homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LBX2hg19_v2_chr2_-_74730087_74730111-0.232.1e-01Click!
EN2hg19_v2_chr7_+_155250824_155250824-0.183.2e-01Click!
GBX2hg19_v2_chr2_-_237076992_237077012-0.125.1e-01Click!

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_36245561 5.31 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_-_76732928 2.15 ENST00000589768.1
CYTH1
cytohesin 1
chrX_-_21676442 2.07 ENST00000379499.2
KLHL34
kelch-like family member 34
chr15_+_58430368 1.92 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr15_+_58430567 1.80 ENST00000536493.1
AQP9
aquaporin 9
chr7_+_77428066 1.78 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
PHTF2
putative homeodomain transcription factor 2
chr7_+_77428149 1.67 ENST00000415251.2
ENST00000275575.7
PHTF2
putative homeodomain transcription factor 2
chr18_+_59000815 1.47 ENST00000262717.4
CDH20
cadherin 20, type 2
chr12_+_81110684 1.43 ENST00000228644.3
MYF5
myogenic factor 5
chr7_-_77427676 1.31 ENST00000257663.3
TMEM60
transmembrane protein 60
chr12_-_89746264 1.19 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chrX_+_135730297 1.16 ENST00000370629.2
CD40LG
CD40 ligand
chr9_+_1050331 1.10 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
DMRT2
doublesex and mab-3 related transcription factor 2
chr12_-_89746173 1.05 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr2_-_224467002 0.96 ENST00000421386.1
ENST00000433889.1
SCG2
secretogranin II
chr3_+_111718173 0.96 ENST00000494932.1
TAGLN3
transgelin 3
chr3_+_111718036 0.91 ENST00000455401.2
TAGLN3
transgelin 3
chr6_-_32157947 0.91 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr14_+_22992573 0.89 ENST00000390516.1
TRAJ21
T cell receptor alpha joining 21
chr17_-_38928414 0.87 ENST00000335552.4
KRT26
keratin 26
chr6_-_26199471 0.84 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr3_+_111717511 0.82 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr3_+_111717600 0.78 ENST00000273368.4
TAGLN3
transgelin 3
chr12_-_56694083 0.78 ENST00000552688.1
ENST00000548041.1
ENST00000551137.1
ENST00000551968.1
ENST00000542324.2
ENST00000546930.1
ENST00000549221.1
ENST00000550159.1
ENST00000550734.1
CS
citrate synthase
chr15_-_55562451 0.76 ENST00000568803.1
RAB27A
RAB27A, member RAS oncogene family
chrX_-_18690210 0.76 ENST00000379984.3
RS1
retinoschisin 1
chr2_-_224467093 0.75 ENST00000305409.2
SCG2
secretogranin II
chr12_-_56693758 0.73 ENST00000547298.1
ENST00000551936.1
ENST00000551253.1
ENST00000551473.1
CS
citrate synthase
chr14_+_32798547 0.73 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr14_+_22739823 0.72 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr17_+_18086392 0.70 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr2_+_17997763 0.70 ENST00000281047.3
MSGN1
mesogenin 1
chr13_-_41593425 0.70 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr5_+_66300464 0.62 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_-_157746909 0.61 ENST00000392274.3
ENST00000361516.3
ENST00000368181.4
FCRL2
Fc receptor-like 2
chr17_-_39203519 0.61 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr2_-_77749446 0.58 ENST00000409911.1
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr2_-_77749474 0.57 ENST00000409093.1
ENST00000409088.3
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr4_+_105828492 0.56 ENST00000506148.1
RP11-556I14.1
RP11-556I14.1
chr14_+_32798462 0.55 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr2_-_77749336 0.54 ENST00000409282.1
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr16_+_69345243 0.53 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr15_-_55562479 0.53 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr15_-_55563072 0.52 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr2_-_61697862 0.51 ENST00000398571.2
USP34
ubiquitin specific peptidase 34
chr3_-_27764190 0.51 ENST00000537516.1
EOMES
eomesodermin
chr12_-_56694142 0.50 ENST00000550655.1
ENST00000548567.1
ENST00000551430.2
ENST00000351328.3
CS
citrate synthase
chr11_-_33913708 0.49 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_18211042 0.47 ENST00000527671.1
RP11-113D6.6
Uncharacterized protein
chr17_-_39191107 0.46 ENST00000344363.5
KRTAP1-3
keratin associated protein 1-3
chr12_-_14133053 0.43 ENST00000609686.1
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr1_+_179923873 0.43 ENST00000367607.3
ENST00000491495.2
CEP350
centrosomal protein 350kDa
chr4_+_183065793 0.43 ENST00000512480.1
TENM3
teneurin transmembrane protein 3
chr1_-_156399184 0.43 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
C1orf61
chromosome 1 open reading frame 61
chr15_-_55562582 0.41 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr4_-_57547870 0.40 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr4_-_39979576 0.40 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chrX_+_130192318 0.39 ENST00000370922.1
ARHGAP36
Rho GTPase activating protein 36
chr5_+_176811431 0.39 ENST00000512593.1
ENST00000324417.5
SLC34A1
solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chrM_+_12331 0.38 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr5_-_82969363 0.38 ENST00000503117.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr6_+_31783291 0.37 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
HSPA1A
heat shock 70kDa protein 1A
chr6_+_43968306 0.36 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr9_+_12693336 0.36 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr5_+_66300446 0.36 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr2_-_77749387 0.35 ENST00000409884.1
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr7_-_111424506 0.35 ENST00000450156.1
ENST00000494651.2
DOCK4
dedicator of cytokinesis 4
chr6_+_26199737 0.35 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr17_-_9929581 0.35 ENST00000437099.2
ENST00000396115.2
GAS7
growth arrest-specific 7
chr1_-_190446759 0.34 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr4_-_57547454 0.34 ENST00000556376.2
HOPX
HOP homeobox
chr15_+_76629064 0.34 ENST00000290759.4
ISL2
ISL LIM homeobox 2
chr1_-_151762900 0.34 ENST00000440583.2
TDRKH
tudor and KH domain containing
chrX_+_134654540 0.33 ENST00000370752.4
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr6_+_111408698 0.33 ENST00000368851.5
SLC16A10
solute carrier family 16 (aromatic amino acid transporter), member 10
chr6_+_49467671 0.33 ENST00000371197.4
ENST00000545705.1
GLYATL3
glycine-N-acyltransferase-like 3
chr12_+_28410128 0.32 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr5_-_82969405 0.31 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr21_-_32253874 0.31 ENST00000332378.4
KRTAP11-1
keratin associated protein 11-1
chr6_-_18264406 0.30 ENST00000515742.1
DEK
DEK oncogene
chr21_+_31812597 0.30 ENST00000334067.3
KRTAP15-1
keratin associated protein 15-1
chrX_+_123097014 0.30 ENST00000394478.1
STAG2
stromal antigen 2
chr16_+_53133070 0.29 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr3_+_35685113 0.29 ENST00000419330.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr6_+_34204642 0.29 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr8_+_38831683 0.29 ENST00000302495.4
HTRA4
HtrA serine peptidase 4
chr3_+_35722487 0.28 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr7_-_92777606 0.28 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr3_+_167453493 0.27 ENST00000295777.5
ENST00000472747.2
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr5_-_95297534 0.27 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr5_-_95297678 0.27 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr6_+_130339710 0.27 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr3_+_115342349 0.26 ENST00000393780.3
GAP43
growth associated protein 43
chr1_+_145507587 0.26 ENST00000330165.8
ENST00000369307.3
RBM8A
RNA binding motif protein 8A
chr6_-_139613269 0.25 ENST00000358430.3
TXLNB
taxilin beta
chr8_-_1922789 0.25 ENST00000521498.1
RP11-439C15.4
RP11-439C15.4
chr15_+_48483736 0.25 ENST00000417307.2
ENST00000559641.1
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chrX_+_591524 0.25 ENST00000554971.1
ENST00000381575.1
SHOX
short stature homeobox
chr8_-_25281747 0.24 ENST00000421054.2
GNRH1
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr18_-_53019208 0.24 ENST00000562607.1
TCF4
transcription factor 4
chr1_-_152131703 0.24 ENST00000316073.3
RPTN
repetin
chr4_-_143226979 0.23 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr9_+_136501478 0.23 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr7_-_111424462 0.23 ENST00000437129.1
DOCK4
dedicator of cytokinesis 4
chr15_+_96904487 0.23 ENST00000600790.1
AC087477.1
Uncharacterized protein
chr6_-_111927062 0.23 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr6_+_140175987 0.22 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr4_+_144354644 0.22 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr4_-_143227088 0.22 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr4_-_120243545 0.22 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr3_-_52090461 0.21 ENST00000296483.6
ENST00000495880.1
DUSP7
dual specificity phosphatase 7
chr3_+_152879985 0.21 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family
chr21_-_43816052 0.21 ENST00000398405.1
TMPRSS3
transmembrane protease, serine 3
chr3_+_35722424 0.21 ENST00000396481.2
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr4_-_174255400 0.21 ENST00000506267.1
HMGB2
high mobility group box 2
chr20_-_45976816 0.21 ENST00000441977.1
ZMYND8
zinc finger, MYND-type containing 8
chr12_+_7013897 0.21 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr12_+_7014064 0.20 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr3_-_157217328 0.20 ENST00000392832.2
ENST00000543418.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr6_+_135502501 0.20 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr17_-_10017864 0.20 ENST00000323816.4
GAS7
growth arrest-specific 7
chrX_+_129473916 0.20 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr3_-_119813264 0.19 ENST00000264235.8
GSK3B
glycogen synthase kinase 3 beta
chr11_-_40315640 0.19 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr11_-_124294789 0.19 ENST00000356130.3
OR8B4
olfactory receptor, family 8, subfamily B, member 4
chr18_+_32173276 0.19 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr1_-_151762943 0.18 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
TDRKH
tudor and KH domain containing
chr19_-_14640005 0.18 ENST00000596853.1
ENST00000596075.1
ENST00000595992.1
ENST00000396969.4
ENST00000601533.1
ENST00000598692.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr4_-_89205879 0.18 ENST00000608933.1
ENST00000315194.4
ENST00000514204.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr12_-_53171128 0.18 ENST00000332411.2
KRT76
keratin 76
chr19_-_40931891 0.17 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chr4_-_89205705 0.17 ENST00000295908.7
ENST00000510548.2
ENST00000508256.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr17_-_9694614 0.17 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr7_+_74072288 0.17 ENST00000443166.1
GTF2I
general transcription factor IIi
chr18_-_44181442 0.17 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr14_-_73360796 0.17 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
DPF3
D4, zinc and double PHD fingers, family 3
chr6_-_26199499 0.16 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr12_-_52828147 0.16 ENST00000252245.5
KRT75
keratin 75
chr2_+_65216462 0.16 ENST00000234256.3
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr17_+_7792101 0.16 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chr19_+_51728316 0.15 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33
CD33 molecule
chr1_-_17766198 0.15 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr1_+_101003687 0.14 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr17_-_48785216 0.14 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr3_+_133292759 0.14 ENST00000431519.2
CDV3
CDV3 homolog (mouse)
chr5_+_179159813 0.14 ENST00000292599.3
MAML1
mastermind-like 1 (Drosophila)
chr15_-_98836406 0.13 ENST00000560360.1
CTD-2544M6.1
CTD-2544M6.1
chr20_+_42523336 0.13 ENST00000428529.1
RP5-1030M6.3
RP5-1030M6.3
chr7_+_18329712 0.13 ENST00000433709.2
HDAC9
histone deacetylase 9
chr17_+_72931876 0.13 ENST00000328801.4
OTOP3
otopetrin 3
chr14_-_78083112 0.13 ENST00000216484.2
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr14_+_60386853 0.13 ENST00000570145.1
LRRC9
leucine rich repeat containing 9
chrX_+_154444643 0.12 ENST00000286428.5
VBP1
von Hippel-Lindau binding protein 1
chr2_-_242089677 0.12 ENST00000405260.1
PASK
PAS domain containing serine/threonine kinase
chr6_-_26250835 0.12 ENST00000446824.2
HIST1H3F
histone cluster 1, H3f
chr17_-_38911580 0.12 ENST00000312150.4
KRT25
keratin 25
chr10_-_56560939 0.12 ENST00000373955.1
PCDH15
protocadherin-related 15
chr20_+_18447771 0.12 ENST00000377603.4
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr19_+_48949030 0.11 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr14_+_72052983 0.11 ENST00000358550.2
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr12_+_64798826 0.11 ENST00000540203.1
XPOT
exportin, tRNA
chr2_+_149402989 0.11 ENST00000397424.2
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr3_+_130162328 0.11 ENST00000512482.1
COL6A5
collagen, type VI, alpha 5
chr5_+_148737562 0.11 ENST00000274569.4
PCYOX1L
prenylcysteine oxidase 1 like
chr15_-_64673630 0.10 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr3_-_157221380 0.10 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr6_-_116833500 0.10 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr3_+_172468749 0.10 ENST00000366254.2
ENST00000415665.1
ENST00000438041.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr1_-_23670752 0.10 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr18_+_32402321 0.10 ENST00000587723.1
DTNA
dystrobrevin, alpha
chr7_+_138145076 0.10 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr17_-_74163159 0.09 ENST00000591615.1
RNF157
ring finger protein 157
chr10_-_56561022 0.09 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
PCDH15
protocadherin-related 15
chr19_-_19302931 0.09 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B
MEF2BNB
MEF2B
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr15_-_64673665 0.09 ENST00000300035.4
KIAA0101
KIAA0101
chr9_-_136933615 0.09 ENST00000371834.2
BRD3
bromodomain containing 3
chr6_-_161695042 0.09 ENST00000366908.5
ENST00000366911.5
ENST00000366905.3
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr18_+_55888767 0.09 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr11_+_57435441 0.09 ENST00000528177.1
ZDHHC5
zinc finger, DHHC-type containing 5
chr6_-_31782813 0.09 ENST00000375654.4
HSPA1L
heat shock 70kDa protein 1-like
chr20_-_50722183 0.09 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr12_-_10955226 0.09 ENST00000240687.2
TAS2R7
taste receptor, type 2, member 7
chr11_+_75526212 0.09 ENST00000356136.3
UVRAG
UV radiation resistance associated
chr4_+_105828537 0.09 ENST00000515649.1
RP11-556I14.1
RP11-556I14.1
chr4_-_174256276 0.09 ENST00000296503.5
HMGB2
high mobility group box 2
chr16_+_9185450 0.08 ENST00000327827.7
C16orf72
chromosome 16 open reading frame 72
chr19_-_59084647 0.08 ENST00000594234.1
ENST00000596039.1
MZF1
myeloid zinc finger 1
chr6_-_161695074 0.08 ENST00000457520.2
ENST00000366906.5
ENST00000320285.4
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr1_+_110881945 0.08 ENST00000602849.1
ENST00000487146.2
RBM15
RNA binding motif protein 15
chrX_+_47077680 0.08 ENST00000522883.1
CDK16
cyclin-dependent kinase 16
chr19_+_14640372 0.08 ENST00000215567.5
ENST00000598298.1
ENST00000596073.1
ENST00000600083.1
ENST00000436007.2
TECR
trans-2,3-enoyl-CoA reductase
chr17_-_8093471 0.08 ENST00000389017.4
C17orf59
chromosome 17 open reading frame 59
chr10_+_99205894 0.08 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr1_-_23670813 0.07 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr7_+_1272522 0.07 ENST00000316333.8
UNCX
UNC homeobox
chr5_+_141303461 0.07 ENST00000508751.1
KIAA0141
KIAA0141
chr3_+_172468505 0.07 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr17_-_7307358 0.07 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr5_+_145826867 0.07 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr4_-_74486109 0.07 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.7 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.4 2.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.3 2.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 0.8 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.2 0.5 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.2 0.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 1.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 1.1 GO:0061055 myotome development(GO:0061055)
0.1 0.7 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.4 GO:0097187 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.1 0.4 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.1 1.4 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 1.7 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.1 0.4 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.1 0.3 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.1 0.6 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1 0.2 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.2 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 2.0 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.2 GO:1990637 response to prolactin(GO:1990637)
0.1 0.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.1 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 1.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 0.1 GO:0003292 cardiac septum cell differentiation(GO:0003292) atrioventricular node cell differentiation(GO:0060922) atrioventricular node cell development(GO:0060928)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.2 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.0 0.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.7 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.3 GO:0070327 aromatic amino acid transport(GO:0015801) thyroid hormone transport(GO:0070327)
0.0 0.2 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.0 0.7 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.3 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 1.1 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 0.9 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808) L-cystine transport(GO:0015811)
0.0 0.4 GO:0097264 self proteolysis(GO:0097264)
0.0 0.5 GO:0007379 segment specification(GO:0007379)
0.0 0.5 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.1 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.3 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 1.6 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.1 GO:0070092 glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.2 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.1 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.4 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.1 GO:0046292 formaldehyde metabolic process(GO:0046292)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.5 GO:0071547 piP-body(GO:0071547)
0.1 1.7 GO:0031045 dense core granule(GO:0031045)
0.0 0.2 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.5 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.2 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:0032302 MutSbeta complex(GO:0032302)
0.0 2.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0016013 syntrophin complex(GO:0016013)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.0 1.2 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:1990909 Wnt signalosome(GO:1990909)
0.0 3.5 GO:0043209 myelin sheath(GO:0043209)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 2.4 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.7 GO:0015254 glycerol channel activity(GO:0015254)
0.7 2.0 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.4 1.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.7 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 2.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.4 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.2 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 0.3 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 6.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.5 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 0.4 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.1 2.2 GO:0031489 myosin V binding(GO:0031489)
0.1 1.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 2.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 1.7 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 2.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.4 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0032181 double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.0 0.2 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) L-cystine transmembrane transporter activity(GO:0015184) L-glutamine transmembrane transporter activity(GO:0015186) alanine transmembrane transporter activity(GO:0022858)
0.0 0.1 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.3 PID ARF6 PATHWAY Arf6 signaling events
0.0 2.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 2.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 PID REELIN PATHWAY Reelin signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 2.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 5.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)