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Illumina Body Map 2: averaged replicates
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Results for EP300
Z-value: 1.62
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Transcription factors associated with EP300
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EP300 | hg19_v2_chr22_+_41487711_41487798 | -0.36 | 4.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_66400533 Show fit | 5.33 |
ENST00000341529.3
|
cadherin 5, type 2 (vascular endothelium) |
|
| chr1_+_153651078 Show fit | 4.39 |
ENST00000368680.3
|
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) |
|
| chr17_+_37783197 Show fit | 3.53 |
ENST00000582680.1
|
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
|
| chr8_+_15397732 Show fit | 3.19 |
ENST00000382020.4
ENST00000506802.1 ENST00000509380.1 ENST00000503731.1 |
tumor suppressor candidate 3 |
|
| chr17_+_37783170 Show fit | 3.05 |
ENST00000254079.4
|
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
|
| chr16_+_28889703 Show fit | 3.04 |
ENST00000357084.3
|
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 |
|
| chr17_+_37782955 Show fit | 2.89 |
ENST00000580825.1
|
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
|
| chr4_-_186456652 Show fit | 2.77 |
ENST00000284767.5
ENST00000284770.5 |
PDZ and LIM domain 3 |
|
| chr4_-_186456766 Show fit | 2.57 |
ENST00000284771.6
|
PDZ and LIM domain 3 |
|
| chr11_-_64527425 Show fit | 2.47 |
ENST00000377432.3
|
phosphorylase, glycogen, muscle |
Network of associatons between targets according to the STRING database.
First level regulatory network of EP300
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.5 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 0.4 | 5.1 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.4 | 5.0 | GO:1903142 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.8 | 4.7 | GO:0030421 | defecation(GO:0030421) |
| 0.3 | 3.2 | GO:0042695 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.0 | 3.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 1.0 | 3.0 | GO:0031446 | regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) |
| 0.2 | 2.9 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 2.8 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.4 | 2.5 | GO:0071503 | positive regulation of lipoprotein particle clearance(GO:0010986) response to heparin(GO:0071503) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 7.8 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 4.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 3.6 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.1 | 3.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 3.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.2 | 3.0 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.1 | 3.0 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.1 | 2.8 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 9.5 | GO:0031751 | D4 dopamine receptor binding(GO:0031751) |
| 0.0 | 8.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 5.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 5.8 | GO:0008201 | heparin binding(GO:0008201) |
| 0.5 | 4.4 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.0 | 4.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.2 | 3.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 3.0 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 2.7 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.6 | 2.5 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 5.0 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 4.3 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 4.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.2 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.8 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 1.7 | SIG CHEMOTAXIS | Genes related to chemotaxis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 6.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 4.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 3.3 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.0 | 2.6 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.1 | 2.5 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 2.5 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.1 | 2.4 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 2.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.2 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |