Project
Illumina Body Map 2: averaged replicates
Navigation
Downloads
Results for EPAS1_BCL3
Z-value: 3.67
Motif logo
Transcription factors associated with EPAS1_BCL3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EPAS1 | hg19_v2_chr2_+_46524537_46524553 | 0.64 | 7.2e-05 | Click! |
| BCL3 | hg19_v2_chr19_+_45254529_45254578 | -0.36 | 4.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EPAS1_BCL3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.5 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 2.1 | 17.1 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.5 | 15.1 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.1 | 14.7 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.9 | 14.0 | GO:0060681 | branch elongation involved in ureteric bud branching(GO:0060681) |
| 0.2 | 13.4 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 1.7 | 13.3 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) |
| 0.6 | 13.2 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.3 | 12.9 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
| 0.2 | 12.9 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 57.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 37.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 28.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 23.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 19.0 | GO:0097060 | synaptic membrane(GO:0097060) |
| 1.6 | 17.6 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.6 | 17.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 15.8 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 15.8 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 15.5 | GO:0045202 | synapse(GO:0045202) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 22.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.3 | 21.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 17.8 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.1 | 16.9 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.4 | 15.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.5 | 15.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 15.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.4 | 15.2 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 1.7 | 13.3 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 62.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 24.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 17.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 15.7 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 13.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 12.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 12.2 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 11.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.4 | 10.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 8.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.0 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.3 | 15.4 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.3 | 14.4 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.2 | 14.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.7 | 11.4 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.8 | 11.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 10.9 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 10.4 | REACTOME PLC BETA MEDIATED EVENTS | Genes involved in PLC beta mediated events |
| 0.1 | 9.2 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 9.1 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |