ISMARA results: ETS1

Project

Illumina Body Map 2: averaged replicates

Navigation

Downloads

Results for ETS1

Z-value: 3.16

Motif logo

Transcription factors associated with ETS1

Gene Symbol	Gene ID	Gene Info
ETS1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000134954.10	ETS proto-oncogene 1, transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ETS1	hg19_v2_chr11_-_128457446_128457461	0.67	2.5e-05	Click!

Activity profile of ETS1 motif

Sorted Z-values of ETS1 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_30393752 Show fit	11.38	ENST00000566517.1 ENST00000605106.1	SEPT1 Ensembl NCBI GeneCards UniProt NextProt Show fit SEPT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	septin 1 Uncharacterized protein
chr16_+_30484054 Show fit	10.82	ENST00000564118.1 ENST00000454514.2 ENST00000433423.2	ITGAL Ensembl NCBI GeneCards UniProt NextProt Show fit	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr16_+_30483962 Show fit	10.42	ENST00000356798.6	ITGAL Ensembl NCBI GeneCards UniProt NextProt Show fit	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr17_+_38673270 Show fit	9.11	ENST00000578280.1	RP5-1028K7.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP5-1028K7.2
chr14_+_22475742 Show fit	8.96	ENST00000390447.3	TRAV19 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 19
chr11_+_67171391 Show fit	8.63	ENST00000312390.5	TBC1D10C Ensembl NCBI GeneCards UniProt NextProt Show fit	TBC1 domain family, member 10C
chr11_+_67171548 Show fit	8.52	ENST00000542590.1	TBC1D10C Ensembl NCBI GeneCards UniProt NextProt Show fit	TBC1 domain family, member 10C
chr1_-_161039456 Show fit	8.46	ENST00000368016.3	ARHGAP30 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GTPase activating protein 30
chr16_+_30484021 Show fit	8.34	ENST00000358164.5	ITGAL Ensembl NCBI GeneCards UniProt NextProt Show fit	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr11_+_67171358 Show fit	8.33	ENST00000526387.1	TBC1D10C Ensembl NCBI GeneCards UniProt NextProt Show fit	TBC1 domain family, member 10C

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ETS1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	72.8	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
1.8	39.8	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.4	37.6	GO:0042100	B cell proliferation(GO:0042100)
1.8	33.7	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0	31.1	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.4	27.2	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
2.5	24.7	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1	20.5	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.4	19.5	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.5	18.3	GO:0048305	immunoglobulin secretion(GO:0048305)

Showing 1 to 10 of 546 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	65.5	GO:0009897	external side of plasma membrane(GO:0009897)
0.9	58.1	GO:0001772	immunological synapse(GO:0001772)
4.0	44.3	GO:0034687	integrin alphaL-beta2 complex(GO:0034687)
0.1	37.9	GO:0034774	secretory granule lumen(GO:0034774)
1.4	33.8	GO:0042101	T cell receptor complex(GO:0042101)
0.3	27.8	GO:0035577	azurophil granule membrane(GO:0035577)
0.1	26.9	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.1	26.8	GO:0030136	clathrin-coated vesicle(GO:0030136)
2.0	26.0	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.8	24.7	GO:0001891	phagocytic cup(GO:0001891)

Showing 1 to 10 of 245 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	73.5	GO:0005096	GTPase activator activity(GO:0005096)
3.7	44.3	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.5	34.1	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.0	31.3	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2	31.1	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
2.9	26.2	GO:0042610	CD8 receptor binding(GO:0042610)
1.1	23.8	GO:0005522	profilin binding(GO:0005522)
0.4	20.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.5	18.9	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.7	16.4	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)

Showing 1 to 10 of 349 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	142.4	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
1.0	70.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.3	41.0	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.9	35.8	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	31.0	PID RAC1 PATHWAY	RAC1 signaling pathway
0.2	24.5	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.3	23.8	PID AURORA B PATHWAY	Aurora B signaling
0.3	22.9	PID BCR 5PATHWAY	BCR signaling pathway
0.3	22.0	PID ATM PATHWAY	ATM pathway
0.3	18.7	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5

Showing 1 to 10 of 70 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	101.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
2.1	67.7	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.9	36.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	30.5	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.5	30.0	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.6	29.4	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.4	27.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	25.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.4	23.1	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.4	21.5	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis

Showing 1 to 10 of 107 entries

Results for ETS1

Z-value: 3.16

Motif logo

Transcription factors associated with ETS1

Activity-expression correlation:

Activity profile of ETS1 motif

Sorted Z-values of ETS1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ETS1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: