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Illumina Body Map 2: averaged replicates
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Results for ETV6
Z-value: 1.98
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Transcription factors associated with ETV6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV6 | hg19_v2_chr12_+_11802753_11802834 | -0.10 | 5.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_67226019 Show fit | 2.30 |
ENST00000379378.3
|
E2F transcription factor 4, p107/p130-binding |
|
| chr17_+_72199721 Show fit | 1.92 |
ENST00000439590.2
ENST00000311111.6 ENST00000584577.1 ENST00000534490.1 ENST00000528433.2 ENST00000533498.1 |
ribosomal protein L38 |
|
| chr12_+_54402790 Show fit | 1.92 |
ENST00000040584.4
|
homeobox C8 |
|
| chr11_-_57102947 Show fit | 1.86 |
ENST00000526696.1
|
structure specific recognition protein 1 |
|
| chr2_-_96971232 Show fit | 1.77 |
ENST00000323853.5
|
small nuclear ribonucleoprotein 200kDa (U5) |
|
| chr22_+_40742497 Show fit | 1.75 |
ENST00000216194.7
|
adenylosuccinate lyase |
|
| chr3_+_45635661 Show fit | 1.71 |
ENST00000440097.1
|
LIM domains containing 1 |
|
| chr20_+_60962143 Show fit | 1.70 |
ENST00000343986.4
|
ribosomal protein S21 |
|
| chr15_-_51058005 Show fit | 1.62 |
ENST00000261854.5
|
signal peptide peptidase like 2A |
|
| chr2_-_96971259 Show fit | 1.51 |
ENST00000349783.5
|
small nuclear ribonucleoprotein 200kDa (U5) |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.3 | GO:0006413 | translational initiation(GO:0006413) |
| 0.7 | 7.0 | GO:1904379 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.1 | 4.3 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.0 | 3.7 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.2 | 3.6 | GO:0000479 | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479) |
| 0.1 | 3.4 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.8 | 3.3 | GO:0000354 | cis assembly of pre-catalytic spliceosome(GO:0000354) |
| 0.7 | 3.3 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 0.0 | 3.3 | GO:0000271 | polysaccharide biosynthetic process(GO:0000271) |
| 0.0 | 3.3 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.6 | 7.0 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.4 | 4.0 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 3.8 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 3.5 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 3.4 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 3.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 3.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 3.1 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 2.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 8.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.3 | 7.0 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 6.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.5 | 5.3 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 0.1 | 3.4 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 3.4 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 3.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 2.9 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 2.8 | GO:0042162 | telomeric DNA binding(GO:0042162) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 2.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.0 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 1.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 1.8 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.8 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 1.7 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.7 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 8.8 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.1 | 8.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 4.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 4.0 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 3.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 3.7 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 3.3 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.3 | 2.9 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 2.8 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |