ISMARA results: FLI1

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Illumina Body Map 2: averaged replicates

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Results for FLI1

Z-value: 2.57

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Transcription factors associated with FLI1

Gene Symbol	Gene ID	Gene Info
FLI1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000151702.12	Fli-1 proto-oncogene, ETS transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FLI1	hg19_v2_chr11_+_128634589_128634685	0.92	8.7e-14	Click!

Activity profile of FLI1 motif

Sorted Z-values of FLI1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_161039456 Show fit	6.62	ENST00000368016.3	ARHGAP30 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GTPase activating protein 30
chr3_+_108541545 Show fit	6.46	ENST00000295756.6	TRAT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor associated transmembrane adaptor 1
chr3_+_108541608 Show fit	6.08	ENST00000426646.1	TRAT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor associated transmembrane adaptor 1
chr10_-_72362515 Show fit	6.05	ENST00000373209.2 ENST00000441259.1	PRF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	perforin 1 (pore forming protein)
chr22_+_23165153 Show fit	5.76	ENST00000390317.2	IGLV2-8 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 2-8
chr1_+_32716840 Show fit	5.45	ENST00000336890.5	LCK Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphocyte-specific protein tyrosine kinase
chr14_+_88471468 Show fit	5.40	ENST00000267549.3	GPR65 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 65
chr1_+_32716857 Show fit	5.33	ENST00000482949.1 ENST00000495610.2	LCK Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphocyte-specific protein tyrosine kinase
chr1_-_167059830 Show fit	5.13	ENST00000367868.3	GPA33 Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein A33 (transmembrane)
chr3_-_183273477 Show fit	5.08	ENST00000341319.3	KLHL6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kelch-like family member 6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FLI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	25.9	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.2	22.2	GO:0042100	B cell proliferation(GO:0042100)
0.2	22.1	GO:0006958	complement activation, classical pathway(GO:0006958)
0.3	21.9	GO:0006910	phagocytosis, recognition(GO:0006910)
0.9	18.5	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	18.2	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.1	16.0	GO:0002377	immunoglobulin production(GO:0002377)
0.2	14.9	GO:0002279	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.8	14.5	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.2	13.2	GO:0032945	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)

Showing 1 to 10 of 506 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	42.4	GO:0001772	immunological synapse(GO:0001772)
0.1	39.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.8	29.5	GO:0042101	T cell receptor complex(GO:0042101)
0.1	28.0	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	20.8	GO:0005615	extracellular space(GO:0005615)
0.0	18.5	GO:0034774	secretory granule lumen(GO:0034774)
0.3	17.8	GO:0019814	immunoglobulin complex(GO:0019814)
1.4	15.7	GO:0034687	integrin alphaL-beta2 complex(GO:0034687)
0.5	13.2	GO:0097342	ripoptosome(GO:0097342)
0.1	13.2	GO:0035579	specific granule membrane(GO:0035579)

Showing 1 to 10 of 203 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	39.0	GO:0003823	antigen binding(GO:0003823)
0.1	26.2	GO:0005096	GTPase activator activity(GO:0005096)
0.2	21.0	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.2	19.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	19.2	GO:0032561	guanyl ribonucleotide binding(GO:0032561)
0.3	18.6	GO:0034987	immunoglobulin receptor binding(GO:0034987)
2.0	18.4	GO:0042610	CD8 receptor binding(GO:0042610)
0.5	16.4	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.3	15.7	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.2	15.5	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)

Showing 1 to 10 of 303 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	69.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	25.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	20.1	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.1	16.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	15.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	15.6	PID IL2 1PATHWAY	IL2-mediated signaling events
0.4	14.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	13.6	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.3	10.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.3	9.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 10 of 86 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	42.7	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.0	27.2	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	22.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.5	18.7	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	18.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	17.2	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.4	16.6	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.3	12.5	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.5	11.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	11.2	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines

Showing 1 to 10 of 99 entries

Results for FLI1

Z-value: 2.57

Motif logo

Transcription factors associated with FLI1

Activity-expression correlation:

Activity profile of FLI1 motif

Sorted Z-values of FLI1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FLI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: