ISMARA results: FOSL2

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Illumina Body Map 2: averaged replicates

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Results for FOSL2_SMARCC1

Z-value: 3.79

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Transcription factors associated with FOSL2_SMARCC1

Gene Symbol	Gene ID	Gene Info
FOSL2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000075426.7	FOS like 2, AP-1 transcription factor subunit
SMARCC1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000173473.6	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOSL2	hg19_v2_chr2_+_28615669_28615733	0.47	7.2e-03	Click!
SMARCC1	hg19_v2_chr3_-_47823298_47823423	0.19	2.9e-01	Click!

Activity profile of FOSL2_SMARCC1 motif

Sorted Z-values of FOSL2_SMARCC1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_89901292 Show fit	23.28	ENST00000448155.2	IGKV1D-39 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1D-39
chr7_+_73245193 Show fit	15.42	ENST00000340958.2	CLDN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	claudin 4
chr2_+_89998789 Show fit	15.33	ENST00000453166.2	IGKV2D-28 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 2D-28
chr2_+_90192768 Show fit	15.13	ENST00000390275.2	IGKV1D-13 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1D-13
chr2_-_89521942 Show fit	14.74	ENST00000482769.1	IGKV2-28 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 2-28
chr2_-_89417335 Show fit	14.46	ENST00000490686.1	IGKV1-17 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-17
chr2_+_89999259 Show fit	13.87	ENST00000558026.1	IGKV2D-28 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 2D-28
chr22_+_23134974 Show fit	13.45	ENST00000390314.2	IGLV2-11 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 2-11
chr2_-_89399845 Show fit	13.24	ENST00000479981.1	IGKV1-16 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-16
chr22_+_23241661 Show fit	12.14	ENST00000390322.2	IGLJ2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda joining 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL2_SMARCC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	237.2	GO:0030449	regulation of complement activation(GO:0030449)
0.6	122.3	GO:0002377	immunoglobulin production(GO:0002377)
0.8	30.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.9	24.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.5	18.3	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.8	15.0	GO:0051546	keratinocyte migration(GO:0051546)
0.6	14.5	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.1	12.5	GO:0007586	digestion(GO:0007586)
0.1	12.3	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
1.0	10.7	GO:0001554	luteolysis(GO:0001554)

Showing 1 to 10 of 318 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	227.3	GO:0005615	extracellular space(GO:0005615)
0.0	124.0	GO:0005576	extracellular region(GO:0005576)
0.4	103.6	GO:0072562	blood microparticle(GO:0072562)
0.7	28.6	GO:0016327	apicolateral plasma membrane(GO:0016327)
2.2	24.2	GO:0005610	laminin-5 complex(GO:0005610)
0.1	14.8	GO:0005882	intermediate filament(GO:0005882)
0.3	13.3	GO:0030057	desmosome(GO:0030057)
0.1	12.9	GO:0009897	external side of plasma membrane(GO:0009897)
0.6	11.6	GO:0071438	invadopodium membrane(GO:0071438)
0.1	10.3	GO:0001772	immunological synapse(GO:0001772)

Showing 1 to 10 of 114 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	345.5	GO:0003823	antigen binding(GO:0003823)
0.0	42.7	GO:0005198	structural molecule activity(GO:0005198)
0.2	35.9	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.2	26.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	24.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	23.6	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3	12.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1	11.3	GO:0050840	extracellular matrix binding(GO:0050840)
0.3	11.0	GO:0017160	Ral GTPase binding(GO:0017160)
0.4	10.5	GO:0045294	alpha-catenin binding(GO:0045294)

Showing 1 to 10 of 198 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	52.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.2	34.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	22.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	15.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	14.8	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.2	13.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	12.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.3	9.5	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	9.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	8.9	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 59 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	36.7	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.5	20.5	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.4	18.3	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	16.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.7	10.5	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.3	9.8	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	9.6	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.2	9.4	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.4	8.5	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	7.9	REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	Genes involved in Post-translational modification: synthesis of GPI-anchored proteins

Showing 1 to 10 of 82 entries

Results for FOSL2_SMARCC1

Z-value: 3.79

Motif logo

Transcription factors associated with FOSL2_SMARCC1

Activity-expression correlation:

Activity profile of FOSL2_SMARCC1 motif

Sorted Z-values of FOSL2_SMARCC1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL2_SMARCC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: