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Illumina Body Map 2: averaged replicates
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Results for FOXA1
Z-value: 2.67
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Transcription factors associated with FOXA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXA1 | hg19_v2_chr14_-_38064198_38064239 | 0.69 | 1.3e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 14.1 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 1.0 | 13.5 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.6 | 11.8 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.7 | 11.4 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 2.1 | 10.5 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 0.3 | 10.2 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.4 | 9.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.1 | 9.5 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.2 | 9.4 | GO:0008211 | glucocorticoid metabolic process(GO:0008211) |
| 0.4 | 9.1 | GO:0031639 | plasminogen activation(GO:0031639) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 37.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 21.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 2.0 | 20.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 18.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 16.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 16.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.5 | 15.5 | GO:0042599 | lamellar body(GO:0042599) |
| 0.1 | 13.1 | GO:0005902 | microvillus(GO:0005902) |
| 3.0 | 11.8 | GO:0071062 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 1.3 | 10.7 | GO:1990357 | terminal web(GO:1990357) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.6 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.3 | 18.5 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 18.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 12.8 | GO:0019210 | kinase inhibitor activity(GO:0019210) |
| 0.1 | 11.9 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 11.5 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 1.4 | 10.9 | GO:0035473 | lipase binding(GO:0035473) |
| 0.1 | 10.5 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.3 | 10.1 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 8.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 44.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 25.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 24.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 17.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 11.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 9.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 9.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 8.9 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 6.2 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 6.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 20.9 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.4 | 17.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.4 | 13.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 13.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 12.7 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.4 | 11.4 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.4 | 10.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.5 | 9.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 9.1 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.2 | 7.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |