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Illumina Body Map 2: averaged replicates
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Results for FOXA2_FOXJ3
Z-value: 1.89
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Transcription factors associated with FOXA2_FOXJ3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXA2 | hg19_v2_chr20_-_22565101_22565223 | -0.38 | 3.3e-02 | Click! |
| FOXJ3 | hg19_v2_chr1_-_42800614_42800649 | -0.34 | 5.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXA2_FOXJ3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 9.2 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.1 | 7.1 | GO:0097503 | sialylation(GO:0097503) |
| 1.4 | 6.9 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 2.1 | 6.2 | GO:0052331 | hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 2.0 | 6.0 | GO:2000910 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 1.3 | 5.2 | GO:0002304 | gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305) |
| 1.6 | 4.9 | GO:0045957 | regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957) |
| 0.8 | 4.2 | GO:2000473 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 0.1 | 4.2 | GO:0042269 | regulation of natural killer cell mediated cytotoxicity(GO:0042269) |
| 0.4 | 3.9 | GO:0071492 | cellular response to UV-A(GO:0071492) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 11.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 9.1 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 7.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 6.0 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 5.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 5.0 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 4.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.4 | 3.3 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.3 | 3.3 | GO:0005579 | membrane attack complex(GO:0005579) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.4 | GO:0005507 | copper ion binding(GO:0005507) |
| 1.4 | 6.8 | GO:0052798 | beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798) |
| 0.3 | 6.3 | GO:0015643 | toxic substance binding(GO:0015643) |
| 1.5 | 6.0 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 1.6 | 4.9 | GO:0001861 | complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877) |
| 0.2 | 4.9 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.4 | 4.7 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 4.4 | GO:0008238 | exopeptidase activity(GO:0008238) |
| 0.2 | 3.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 1.2 | 3.7 | GO:1904854 | proteasome core complex binding(GO:1904854) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 7.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 5.1 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 4.2 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 4.0 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 2.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 2.7 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 2.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.4 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 2.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.6 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.4 | 9.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 7.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.4 | 7.0 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.2 | 6.8 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.2 | 6.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 4.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 4.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 4.2 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 3.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |