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Illumina Body Map 2: averaged replicates
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Results for FOXA3_FOXC2
Z-value: 1.96
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Transcription factors associated with FOXA3_FOXC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXA3 | hg19_v2_chr19_+_46367518_46367567 | 0.64 | 8.4e-05 | Click! |
| FOXC2 | hg19_v2_chr16_+_86600857_86600921 | 0.13 | 4.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXA3_FOXC2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 10.8 | GO:0010193 | response to ozone(GO:0010193) |
| 0.6 | 10.6 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 2.0 | 10.0 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 0.5 | 8.7 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.6 | 8.4 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.1 | 8.4 | GO:0001958 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.4 | 8.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.7 | 6.7 | GO:0030450 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) |
| 1.5 | 6.0 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) |
| 1.1 | 5.6 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.6 | GO:0005615 | extracellular space(GO:0005615) |
| 1.4 | 13.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 13.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 12.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 2.5 | 10.0 | GO:0071062 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 9.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 9.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.1 | 8.4 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.0 | 7.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 6.4 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.8 | GO:0008201 | heparin binding(GO:0008201) |
| 1.0 | 10.8 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.4 | 8.7 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 8.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 7.4 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 7.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.2 | 7.1 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.2 | 7.0 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
| 1.5 | 6.0 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.0 | 5.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 17.5 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 13.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 12.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 11.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 7.1 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 6.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 5.6 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 3.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.4 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 13.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 9.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.4 | 8.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 8.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.3 | 7.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 6.9 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 6.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 6.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 5.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |