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Illumina Body Map 2: averaged replicates
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Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Z-value: 2.05
Motif logo
Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000251493.2 | forkhead box D1 | |
| ENSG00000150907.6 | forkhead box O1 | |
| ENSG00000204060.4 | forkhead box O6 | |
| ENSG00000176165.7 | forkhead box G1 | |
| ENSG00000114861.14 | forkhead box P1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXG1 | hg19_v2_chr14_+_29234870_29235050 | -0.61 | 2.3e-04 | Click! |
| FOXO1 | hg19_v2_chr13_-_41240717_41240735 | 0.42 | 1.6e-02 | Click! |
| FOXP1 | hg19_v2_chr3_-_71179699_71179744 | 0.15 | 4.1e-01 | Click! |
| FOXO6 | hg19_v2_chr1_+_41827594_41827594 | -0.12 | 5.1e-01 | Click! |
| FOXD1 | hg19_v2_chr5_-_72744336_72744359 | -0.04 | 8.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_145438469 Show fit | 5.60 |
ENST00000369317.4
|
thioredoxin interacting protein |
|
| chr10_+_63808970 Show fit | 5.44 |
ENST00000309334.5
|
AT rich interactive domain 5B (MRF1-like) |
|
| chr18_+_3449330 Show fit | 5.36 |
ENST00000549253.1
|
TGFB-induced factor homeobox 1 |
|
| chr21_+_39668478 Show fit | 4.77 |
ENST00000398927.1
|
potassium inwardly-rectifying channel, subfamily J, member 15 |
|
| chr7_-_95225768 Show fit | 4.74 |
ENST00000005178.5
|
pyruvate dehydrogenase kinase, isozyme 4 |
|
| chr7_+_134832808 Show fit | 4.38 |
ENST00000275767.3
|
transmembrane protein 140 |
|
| chrX_+_135251835 Show fit | 3.81 |
ENST00000456445.1
|
four and a half LIM domains 1 |
|
| chrX_+_135251783 Show fit | 3.78 |
ENST00000394153.2
|
four and a half LIM domains 1 |
|
| chr21_+_39668831 Show fit | 3.74 |
ENST00000419868.1
|
potassium inwardly-rectifying channel, subfamily J, member 15 |
|
| chr3_-_168865522 Show fit | 3.52 |
ENST00000464456.1
|
MDS1 and EVI1 complex locus |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.1 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.2 | 10.7 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 1.9 | 7.6 | GO:0090096 | regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 0.5 | 7.1 | GO:0033227 | dsRNA transport(GO:0033227) |
| 1.2 | 7.0 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.0 | 6.2 | GO:0042493 | response to drug(GO:0042493) |
| 0.2 | 6.0 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.2 | 5.6 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.1 | 5.4 | GO:0030318 | melanocyte differentiation(GO:0030318) |
| 0.2 | 5.2 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 56.1 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 26.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 11.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 8.8 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 8.2 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 7.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 6.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 6.6 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.1 | 6.4 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 6.1 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.4 | 10.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 9.3 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 8.7 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.2 | 8.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 1.2 | 7.1 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.2 | 5.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 5.4 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.3 | 5.1 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 5.1 | GO:0001221 | transcription cofactor binding(GO:0001221) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 15.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 11.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 11.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.2 | 10.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 9.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 8.2 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 5.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 5.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 5.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 10.7 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 9.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 8.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 8.4 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.1 | 6.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 6.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 5.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 5.2 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.2 | 4.7 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |