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Illumina Body Map 2: averaged replicates
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Results for FOXD3_FOXI1_FOXF1
Z-value: 2.01
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Transcription factors associated with FOXD3_FOXI1_FOXF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXI1 | hg19_v2_chr5_+_169532896_169532917 | -0.23 | 2.0e-01 | Click! |
| FOXD3 | hg19_v2_chr1_+_63788730_63788730 | -0.22 | 2.4e-01 | Click! |
| FOXF1 | hg19_v2_chr16_+_86544113_86544145 | -0.13 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_35721106 Show fit | 4.23 |
ENST00000474696.1
ENST00000412048.1 ENST00000396482.2 ENST00000432682.1 |
cAMP-regulated phosphoprotein, 21kDa |
|
| chr3_+_35721182 Show fit | 3.69 |
ENST00000413378.1
ENST00000417925.1 |
cAMP-regulated phosphoprotein, 21kDa |
|
| chr3_+_50712672 Show fit | 3.36 |
ENST00000266037.9
|
dedicator of cytokinesis 3 |
|
| chr16_+_6069586 Show fit | 3.36 |
ENST00000547372.1
|
RNA binding protein, fox-1 homolog (C. elegans) 1 |
|
| chr12_-_39734783 Show fit | 3.18 |
ENST00000552961.1
|
kinesin family member 21A |
|
| chr8_+_79428539 Show fit | 2.95 |
ENST00000352966.5
|
protein kinase (cAMP-dependent, catalytic) inhibitor alpha |
|
| chr20_+_33563206 Show fit | 2.86 |
ENST00000262873.7
|
myosin, heavy chain 7B, cardiac muscle, beta |
|
| chr12_-_71551652 Show fit | 2.83 |
ENST00000546561.1
|
tetraspanin 8 |
|
| chr3_+_35721130 Show fit | 2.74 |
ENST00000432450.1
|
cAMP-regulated phosphoprotein, 21kDa |
|
| chr11_-_111781610 Show fit | 2.67 |
ENST00000525823.1
|
crystallin, alpha B |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD3_FOXI1_FOXF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 8.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.3 | 6.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.3 | 6.4 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 6.0 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.3 | 5.9 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.0 | 5.0 | GO:0034332 | adherens junction organization(GO:0034332) |
| 0.0 | 4.9 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
| 0.2 | 4.6 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 4.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 13.4 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.5 | 9.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 9.0 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 8.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 7.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 7.3 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 5.6 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.2 | 4.9 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 4.7 | GO:0043194 | axon initial segment(GO:0043194) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.4 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.2 | 7.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 7.7 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.2 | 7.5 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 6.9 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.1 | 6.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.2 | 6.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 6.3 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 6.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.4 | 5.8 | GO:1903136 | cuprous ion binding(GO:1903136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 7.0 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 4.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 2.7 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 2.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 2.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 2.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 2.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 2.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 7.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 6.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 6.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 4.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 4.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 4.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 4.2 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 4.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |