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Illumina Body Map 2: averaged replicates
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Results for FOXK1_FOXP2_FOXB1_FOXP3
Z-value: 3.39
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Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000164916.9 | forkhead box K1 | |
| ENSG00000128573.18 | forkhead box P2 | |
| ENSG00000171956.5 | forkhead box B1 | |
| ENSG00000049768.10 | forkhead box P3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXP3 | hg19_v2_chrX_-_49121165_49121288 | -0.78 | 1.3e-07 | Click! |
| FOXP2 | hg19_v2_chr7_+_114055052_114055378 | 0.58 | 4.5e-04 | Click! |
| FOXK1 | hg19_v2_chr7_+_4721885_4721945 | -0.41 | 2.1e-02 | Click! |
| FOXB1 | hg19_v2_chr15_+_60296421_60296464 | -0.19 | 3.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_71551652 Show fit | 19.93 |
ENST00000546561.1
|
tetraspanin 8 |
|
| chr17_+_72426891 Show fit | 14.04 |
ENST00000392627.1
|
G protein-coupled receptor, family C, group 5, member C |
|
| chr12_-_71551868 Show fit | 12.39 |
ENST00000247829.3
|
tetraspanin 8 |
|
| chr4_-_152149033 Show fit | 12.11 |
ENST00000514152.1
|
SH3 domain containing 19 |
|
| chr10_+_123923105 Show fit | 11.91 |
ENST00000368999.1
|
transforming, acidic coiled-coil containing protein 2 |
|
| chr10_-_101841588 Show fit | 11.70 |
ENST00000370418.3
|
carboxypeptidase N, polypeptide 1 |
|
| chr10_+_123923205 Show fit | 10.69 |
ENST00000369004.3
ENST00000260733.3 |
transforming, acidic coiled-coil containing protein 2 |
|
| chr17_+_9745786 Show fit | 10.17 |
ENST00000304773.5
|
glucagon-like peptide 2 receptor |
|
| chr10_+_123922941 Show fit | 10.16 |
ENST00000360561.3
|
transforming, acidic coiled-coil containing protein 2 |
|
| chr5_-_42811986 Show fit | 10.09 |
ENST00000511224.1
ENST00000507920.1 ENST00000510965.1 |
selenoprotein P, plasma, 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 50.9 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.5 | 44.9 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.6 | 25.6 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 25.2 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.4 | 20.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 1.5 | 20.4 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.8 | 19.7 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.1 | 19.2 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 1.3 | 18.7 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 2.2 | 17.8 | GO:0048014 | Tie signaling pathway(GO:0048014) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 97.8 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.3 | 73.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 55.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 40.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 39.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.7 | 29.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 26.4 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.2 | 25.4 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.5 | 25.2 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 1.7 | 25.0 | GO:0030478 | actin cap(GO:0030478) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 54.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 42.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 35.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 33.2 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.6 | 27.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.7 | 25.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.3 | 23.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 23.4 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.1 | 20.4 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) |
| 0.0 | 20.2 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 50.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 34.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 34.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.3 | 31.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 25.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 25.5 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.3 | 20.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 20.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 18.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 17.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 46.8 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.5 | 36.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 24.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.9 | 23.8 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.5 | 22.8 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 21.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.3 | 19.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.6 | 17.4 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 1.0 | 17.2 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.5 | 16.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |