ISMARA results: FOXL1

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Illumina Body Map 2: averaged replicates

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Results for FOXL1

Z-value: 3.21

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Transcription factors associated with FOXL1

Gene Symbol	Gene ID	Gene Info
FOXL1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000176678.4	forkhead box L1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXL1	hg19_v2_chr16_+_86609939_86609974	0.03	8.7e-01	Click!

Activity profile of FOXL1 motif

Sorted Z-values of FOXL1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_89310012 Show fit	9.96	ENST00000493819.1	IGKV1-9 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-9
chr2_-_89417335 Show fit	9.64	ENST00000490686.1	IGKV1-17 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-17
chr4_-_71532339 Show fit	8.50	ENST00000254801.4	IGJ Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_71532668 Show fit	7.92	ENST00000510437.1	IGJ Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_100242549 Show fit	7.87	ENST00000305046.8 ENST00000394887.3	ADH1B Ensembl NCBI GeneCards UniProt NextProt Show fit	alcohol dehydrogenase 1B (class I), beta polypeptide
chr2_-_89266286 Show fit	7.86	ENST00000464162.1	IGKV1-6 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-6
chr2_-_89399845 Show fit	7.70	ENST00000479981.1	IGKV1-16 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-16
chr2_+_90259593 Show fit	7.48	ENST00000471857.1	IGKV1D-8 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1D-8
chr3_+_151531810 Show fit	7.31	ENST00000232892.7	AADAC Ensembl NCBI GeneCards UniProt NextProt Show fit	arylacetamide deacetylase
chr7_+_80275953 Show fit	7.06	ENST00000538969.1 ENST00000544133.1 ENST00000433696.2	CD36 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD36 molecule (thrombospondin receptor)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	208.8	GO:0006958	complement activation, classical pathway(GO:0006958)
0.4	88.4	GO:0002377	immunoglobulin production(GO:0002377)
2.2	26.6	GO:0072564	blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
1.0	13.4	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.1	11.7	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.7	10.9	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.5	10.9	GO:0006069	ethanol oxidation(GO:0006069)
0.3	10.6	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
1.5	8.9	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1	8.8	GO:0006730	one-carbon metabolic process(GO:0006730)

Showing 1 to 10 of 399 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	131.1	GO:0005615	extracellular space(GO:0005615)
1.7	90.6	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.4	74.1	GO:0072562	blood microparticle(GO:0072562)
0.7	28.8	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	14.5	GO:1904724	tertiary granule lumen(GO:1904724)
0.1	13.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	12.9	GO:0005667	transcription factor complex(GO:0005667)
0.4	11.6	GO:0005614	interstitial matrix(GO:0005614)
0.7	10.9	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	9.8	GO:0035578	azurophil granule lumen(GO:0035578)

Showing 1 to 10 of 146 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	193.7	GO:0003823	antigen binding(GO:0003823)
1.3	86.4	GO:0034987	immunoglobulin receptor binding(GO:0034987)
2.4	26.6	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.2	23.4	GO:0005518	collagen binding(GO:0005518)
0.1	17.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.5	15.8	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	13.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	12.0	GO:0005044	scavenger receptor activity(GO:0005044)
1.2	11.2	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	9.7	GO:0003714	transcription corepressor activity(GO:0003714)

Showing 1 to 10 of 270 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	21.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	20.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	20.3	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	19.7	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	9.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	7.3	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.1	7.0	PID IL12 2PATHWAY	IL12-mediated signaling events
0.1	6.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	6.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	5.9	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin

Showing 1 to 10 of 69 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	31.9	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4	21.0	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	15.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.6	10.9	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.3	10.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	10.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	10.1	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.3	9.5	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.6	9.3	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	7.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation

Showing 1 to 10 of 102 entries

Results for FOXL1

Z-value: 3.21

Motif logo

Transcription factors associated with FOXL1

Activity-expression correlation:

Activity profile of FOXL1 motif

Sorted Z-values of FOXL1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: