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Illumina Body Map 2: averaged replicates
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Results for FOXO4
Z-value: 2.00
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Transcription factors associated with FOXO4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXO4 | hg19_v2_chrX_+_70316005_70316047 | 0.20 | 2.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_105627735 Show fit | 4.88 |
ENST00000254765.3
|
popeye domain containing 3 |
|
| chr12_-_111358372 Show fit | 4.34 |
ENST00000548438.1
ENST00000228841.8 |
myosin, light chain 2, regulatory, cardiac, slow |
|
| chr7_-_95225768 Show fit | 4.25 |
ENST00000005178.5
|
pyruvate dehydrogenase kinase, isozyme 4 |
|
| chr10_+_123923105 Show fit | 4.08 |
ENST00000368999.1
|
transforming, acidic coiled-coil containing protein 2 |
|
| chr10_-_4285835 Show fit | 3.98 |
ENST00000454470.1
|
long intergenic non-protein coding RNA 702 |
|
| chr10_-_4285923 Show fit | 3.76 |
ENST00000418372.1
ENST00000608792.1 |
long intergenic non-protein coding RNA 702 |
|
| chr11_+_113930955 Show fit | 3.40 |
ENST00000535700.1
|
zinc finger and BTB domain containing 16 |
|
| chr10_-_13570533 Show fit | 3.32 |
ENST00000396900.2
ENST00000396898.2 |
BEN domain containing 7 |
|
| chr10_+_123923205 Show fit | 3.31 |
ENST00000369004.3
ENST00000260733.3 |
transforming, acidic coiled-coil containing protein 2 |
|
| chr4_-_100242549 Show fit | 3.20 |
ENST00000305046.8
ENST00000394887.3 |
alcohol dehydrogenase 1B (class I), beta polypeptide |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXO4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 14.1 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.0 | 10.2 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.2 | 9.6 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 8.7 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.6 | 5.8 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.0 | 5.4 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.1 | 5.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.3 | 5.0 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.3 | 4.5 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.4 | 4.4 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 8.1 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 4.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.4 | 4.6 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.3 | 4.5 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.1 | 4.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 4.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 4.2 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 4.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.2 | 3.5 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.0 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.2 | 9.6 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 8.7 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.3 | 5.8 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 5.6 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.1 | 5.4 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 5.0 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 5.0 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.2 | 4.4 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 1.1 | 4.2 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.2 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 4.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 3.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.9 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 2.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 2.2 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 2.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 2.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.0 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 1.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.3 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 7.8 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.0 | 5.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 5.3 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.3 | 5.0 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 4.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 3.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 3.6 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 3.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 2.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |