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Illumina Body Map 2: averaged replicates
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Results for GATA1_GATA4
Z-value: 3.11
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Transcription factors associated with GATA1_GATA4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA4 | hg19_v2_chr8_+_11561660_11561751 | 0.25 | 1.6e-01 | Click! |
| GATA1 | hg19_v2_chrX_+_48644962_48644983 | -0.01 | 9.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_99531709 Show fit | 10.01 |
ENST00000266066.3
|
secreted frizzled-related protein 5 |
|
| chr18_+_19749386 Show fit | 8.03 |
ENST00000269216.3
|
GATA binding protein 6 |
|
| chr12_-_114841703 Show fit | 7.97 |
ENST00000526441.1
|
T-box 5 |
|
| chr11_-_116708302 Show fit | 6.95 |
ENST00000375320.1
ENST00000359492.2 ENST00000375329.2 ENST00000375323.1 |
apolipoprotein A-I |
|
| chr19_-_55669093 Show fit | 6.83 |
ENST00000344887.5
|
troponin I type 3 (cardiac) |
|
| chr1_-_27240455 Show fit | 6.31 |
ENST00000254227.3
|
nuclear receptor subfamily 0, group B, member 2 |
|
| chr10_-_48416849 Show fit | 6.04 |
ENST00000249598.1
|
growth differentiation factor 2 |
|
| chr11_-_47374246 Show fit | 5.71 |
ENST00000545968.1
ENST00000399249.2 ENST00000256993.4 |
myosin binding protein C, cardiac |
|
| chr2_-_69098566 Show fit | 5.67 |
ENST00000295379.1
|
bone morphogenetic protein 10 |
|
| chr7_-_99277610 Show fit | 5.65 |
ENST00000343703.5
ENST00000222982.4 ENST00000439761.1 ENST00000339843.2 |
cytochrome P450, family 3, subfamily A, polypeptide 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA1_GATA4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 18.0 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.4 | 17.3 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 3.9 | 15.6 | GO:0009822 | alkaloid catabolic process(GO:0009822) |
| 0.8 | 10.7 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.6 | 10.3 | GO:0034197 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 1.4 | 10.0 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
| 0.1 | 8.2 | GO:0031100 | organ regeneration(GO:0031100) |
| 2.7 | 8.0 | GO:0007493 | endodermal cell fate determination(GO:0007493) |
| 2.7 | 8.0 | GO:0003218 | cardiac left ventricle formation(GO:0003218) |
| 2.4 | 7.3 | GO:0010949 | negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 32.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 28.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 25.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 15.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 13.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.6 | 9.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 9.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 9.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.3 | 7.5 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.4 | 7.4 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.2 | 13.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 11.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.5 | 10.6 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.1 | 10.2 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 2.3 | 9.4 | GO:0030343 | vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643) |
| 0.1 | 8.8 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.3 | 8.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 8.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 7.8 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 17.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 14.8 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 12.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 9.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 6.6 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 6.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.3 | 6.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 5.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 4.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 24.1 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.5 | 14.6 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 14.2 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.9 | 13.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 13.1 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 11.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.3 | 10.8 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 10.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 9.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 8.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |