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Illumina Body Map 2: averaged replicates
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Results for GATA2
Z-value: 2.23
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Transcription factors associated with GATA2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA2 | hg19_v2_chr3_-_128212016_128212051 | -0.04 | 8.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_33563821 Show fit | 5.58 |
ENST00000321505.4
ENST00000265654.5 ENST00000389726.3 |
KIAA1549-like |
|
| chr12_+_121088291 Show fit | 4.57 |
ENST00000351200.2
|
calcium binding protein 1 |
|
| chr6_-_127780510 Show fit | 4.46 |
ENST00000487331.2
ENST00000483725.3 |
KIAA0408 |
|
| chr9_+_87286997 Show fit | 4.22 |
ENST00000395866.2
|
neurotrophic tyrosine kinase, receptor, type 2 |
|
| chr1_+_160085567 Show fit | 4.17 |
ENST00000392233.3
|
ATPase, Na+/K+ transporting, alpha 2 polypeptide |
|
| chr20_+_44650348 Show fit | 4.12 |
ENST00000454036.2
|
solute carrier family 12 (potassium/chloride transporter), member 5 |
|
| chr3_+_111718173 Show fit | 3.95 |
ENST00000494932.1
|
transgelin 3 |
|
| chr18_-_4455283 Show fit | 3.94 |
ENST00000315677.3
|
discs, large (Drosophila) homolog-associated protein 1 |
|
| chr16_-_30023615 Show fit | 3.91 |
ENST00000564979.1
ENST00000563378.1 |
double C2-like domains, alpha |
|
| chrX_-_20074895 Show fit | 3.69 |
ENST00000543767.1
|
MAP7 domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 11.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 1.6 | 9.7 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.8 | 8.8 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 8.6 | GO:0050770 | regulation of axonogenesis(GO:0050770) |
| 0.3 | 8.0 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.6 | 7.9 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 2.6 | 7.7 | GO:1903280 | negative regulation of calcium:sodium antiporter activity(GO:1903280) |
| 0.2 | 7.7 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.1 | 7.4 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 12.4 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.2 | 12.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 11.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 10.8 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 10.2 | GO:0043198 | dendritic shaft(GO:0043198) |
| 1.1 | 9.7 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 9.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 9.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.3 | 8.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 12.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 10.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.9 | 9.7 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 9.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 9.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 9.3 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 9.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.9 | 8.5 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 0.4 | 8.5 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 7.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 7.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 5.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 4.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 4.5 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 4.0 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 3.8 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 3.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 3.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 13.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 10.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 9.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.3 | 7.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 7.8 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.1 | 7.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 7.4 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.2 | 6.4 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 4.8 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |