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Illumina Body Map 2: averaged replicates
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Results for GFI1B
Z-value: 2.14
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Transcription factors associated with GFI1B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GFI1B | hg19_v2_chr9_+_135854091_135854159 | -0.64 | 8.9e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_119184702 Show fit | 5.40 |
ENST00000549104.1
|
CTA-109P11.4 |
|
| chr3_-_149688971 Show fit | 4.89 |
ENST00000498307.1
ENST00000489155.1 |
profilin 2 |
|
| chr18_-_24445729 Show fit | 4.76 |
ENST00000383168.4
|
aquaporin 4 |
|
| chr14_-_80677970 Show fit | 4.39 |
ENST00000438257.4
|
deiodinase, iodothyronine, type II |
|
| chr5_+_36608422 Show fit | 4.32 |
ENST00000381918.3
|
solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
|
| chr3_+_149689066 Show fit | 3.70 |
ENST00000593416.1
|
LOC646903 protein; Uncharacterized protein |
|
| chr17_+_70117153 Show fit | 3.59 |
ENST00000245479.2
|
SRY (sex determining region Y)-box 9 |
|
| chr11_+_27076764 Show fit | 3.46 |
ENST00000525090.1
|
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 |
|
| chr4_-_176828307 Show fit | 3.46 |
ENST00000513365.1
ENST00000513667.1 ENST00000503563.1 |
glycoprotein M6A |
|
| chr10_+_60936921 Show fit | 3.02 |
ENST00000373878.3
|
phytanoyl-CoA 2-hydroxylase interacting protein-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of GFI1B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.5 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.6 | 9.5 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.5 | 9.5 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.6 | 7.0 | GO:0070779 | gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 6.0 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.2 | 5.5 | GO:0006833 | water transport(GO:0006833) |
| 0.3 | 5.4 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.1 | 5.2 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 1.3 | 5.1 | GO:1901846 | positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846) |
| 1.3 | 5.1 | GO:0019285 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 11.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 9.5 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 8.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 5.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 5.2 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.4 | 5.1 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.2 | 4.6 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 4.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 4.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 1.2 | 9.5 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.1 | 9.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 7.8 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.7 | 7.0 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 5.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 5.4 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 5.4 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 5.1 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 4.9 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 4.4 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 3.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 3.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.6 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 2.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 2.6 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 1.9 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 1.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.2 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.9 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 9.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 7.7 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.0 | 7.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.3 | 4.8 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 4.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 3.3 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.1 | 3.3 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 2.9 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 2.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |