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Illumina Body Map 2: averaged replicates
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Results for GGCAGUG
Z-value: 2.07
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miRNA associated with seed GGCAGUG
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_175223313 Show fit | 8.65 |
ENST00000359546.4
|
complexin 2 |
|
| chr10_+_105036909 Show fit | 7.72 |
ENST00000369849.4
|
internexin neuronal intermediate filament protein, alpha |
|
| chr1_+_205012293 Show fit | 7.14 |
ENST00000331830.4
|
contactin 2 (axonal) |
|
| chr20_+_10199468 Show fit | 6.16 |
ENST00000254976.2
ENST00000304886.2 |
synaptosomal-associated protein, 25kDa |
|
| chr12_+_79258547 Show fit | 5.96 |
ENST00000457153.2
|
synaptotagmin I |
|
| chr1_+_181452678 Show fit | 4.63 |
ENST00000367570.1
ENST00000526775.1 ENST00000357570.5 ENST00000358338.5 ENST00000367567.4 |
calcium channel, voltage-dependent, R type, alpha 1E subunit |
|
| chr16_+_56225248 Show fit | 4.56 |
ENST00000262493.6
|
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O |
|
| chr13_-_25746416 Show fit | 4.53 |
ENST00000515384.1
ENST00000357816.2 |
APC membrane recruitment protein 2 |
|
| chr1_-_151688528 Show fit | 4.09 |
ENST00000290585.4
|
CUGBP, Elav-like family member 3 |
|
| chr5_+_110559784 Show fit | 4.04 |
ENST00000282356.4
|
calcium/calmodulin-dependent protein kinase IV |
Network of associatons between targets according to the STRING database.
First level regulatory network of GGCAGUG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.5 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.3 | 8.6 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.6 | 7.7 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 1.8 | 7.1 | GO:0060168 | regulation of axon diameter(GO:0031133) positive regulation of adenosine receptor signaling pathway(GO:0060168) |
| 1.5 | 6.2 | GO:1990926 | short-term synaptic potentiation(GO:1990926) |
| 1.0 | 6.0 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.4 | 5.4 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 4.9 | GO:0035640 | exploration behavior(GO:0035640) |
| 0.1 | 4.9 | GO:0014072 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.1 | 4.5 | GO:0007398 | ectoderm development(GO:0007398) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.8 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 14.3 | GO:0045202 | synapse(GO:0045202) |
| 1.1 | 10.5 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.5 | 7.7 | GO:0005883 | neurofilament(GO:0005883) |
| 0.2 | 6.8 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 1.2 | 6.2 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.7 | 6.0 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.4 | 5.3 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.1 | 4.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 4.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 10.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 8.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 7.7 | GO:0043621 | protein self-association(GO:0043621) |
| 0.1 | 6.6 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.5 | 6.0 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.2 | 4.9 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 4.7 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.3 | 4.6 | GO:0051430 | corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.1 | 4.6 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 6.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 3.8 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 3.7 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 3.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.2 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.0 | 1.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.0 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.1 | 11.1 | REACTOME PLC BETA MEDIATED EVENTS | Genes involved in PLC beta mediated events |
| 0.1 | 7.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 6.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 6.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 4.2 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.1 | 3.9 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 3.4 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 3.0 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.2 | 2.7 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |