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Illumina Body Map 2: averaged replicates
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Results for GLI2
Z-value: 2.08
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Transcription factors associated with GLI2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI2 | hg19_v2_chr2_+_121493717_121493823 | -0.30 | 9.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_139927462 Show fit | 3.94 |
ENST00000314412.6
|
fucosyltransferase 7 (alpha (1,3) fucosyltransferase) |
|
| chr7_+_142423143 Show fit | 3.76 |
ENST00000390399.3
|
T cell receptor beta variable 27 |
|
| chr19_+_17638059 Show fit | 3.58 |
ENST00000599164.1
ENST00000449408.2 ENST00000600871.1 ENST00000599124.1 |
family with sequence similarity 129, member C |
|
| chr3_+_32993065 Show fit | 3.34 |
ENST00000330953.5
|
chemokine (C-C motif) receptor 4 |
|
| chr21_-_46330545 Show fit | 3.15 |
ENST00000320216.6
ENST00000397852.1 |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
|
| chr19_+_17858509 Show fit | 3.15 |
ENST00000594202.1
ENST00000252771.7 ENST00000389133.4 |
FCH domain only 1 |
|
| chr17_-_3819751 Show fit | 3.11 |
ENST00000225538.3
|
purinergic receptor P2X, ligand-gated ion channel, 1 |
|
| chr1_-_207096529 Show fit | 3.11 |
ENST00000525793.1
ENST00000529560.1 |
Fas apoptotic inhibitory molecule 3 |
|
| chr15_+_29211570 Show fit | 2.85 |
ENST00000558804.1
|
amyloid beta (A4) precursor protein-binding, family A, member 2 |
|
| chr11_+_124609823 Show fit | 2.76 |
ENST00000412681.2
|
neurogranin (protein kinase C substrate, RC3) |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | GO:0018196 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
| 2.4 | 7.2 | GO:0002522 | leukocyte migration involved in immune response(GO:0002522) |
| 0.1 | 6.6 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.0 | 5.2 | GO:0035308 | negative regulation of protein dephosphorylation(GO:0035308) |
| 0.0 | 5.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 4.5 | GO:1900273 | positive regulation of long-term synaptic potentiation(GO:1900273) |
| 0.1 | 4.5 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.3 | 4.2 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.8 | 4.1 | GO:0002442 | serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554) |
| 0.0 | 3.9 | GO:0070671 | interleukin-12-mediated signaling pathway(GO:0035722) response to interleukin-12(GO:0070671) cellular response to interleukin-12(GO:0071349) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 13.0 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.3 | 6.6 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.4 | 6.5 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.1 | 6.5 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 6.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 4.5 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 4.2 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 4.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 3.8 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.8 | 7.6 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.2 | 5.3 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 4.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.4 | 4.7 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.1 | 4.5 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.3 | 4.4 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.3 | 4.3 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.4 | 3.9 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.0 | 3.9 | GO:0019843 | rRNA binding(GO:0019843) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 7.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 7.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 5.9 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.2 | 4.4 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 4.4 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 3.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 3.3 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.1 | 3.3 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 3.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 6.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 5.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.0 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 3.9 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 3.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 3.5 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.2 | 3.3 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.1 | 3.3 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 3.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |