ISMARA results: GLI3

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Illumina Body Map 2: averaged replicates

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Results for GLI3

Z-value: 1.86

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Transcription factors associated with GLI3

Gene Symbol	Gene ID	Gene Info
GLI3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000106571.8	GLI family zinc finger 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GLI3	hg19_v2_chr7_-_42276612_42276782	0.45	1.0e-02	Click!

Activity profile of GLI3 motif

Sorted Z-values of GLI3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_+_23247030 Show fit	2.91	ENST00000390324.2	IGLJ3 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda joining 3
chr9_+_34458771 Show fit	2.61	ENST00000437363.1 ENST00000242317.4	DNAI1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dynein, axonemal, intermediate chain 1
chr14_-_36983034 Show fit	2.48	ENST00000518529.2	SFTA3 Ensembl NCBI GeneCards UniProt NextProt Show fit	surfactant associated 3
chr12_-_45270077 Show fit	2.31	ENST00000551601.1 ENST00000549027.1 ENST00000452445.2	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)
chr20_+_62327996 Show fit	2.26	ENST00000369996.1	TNFRSF6B Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor receptor superfamily, member 6b, decoy
chr2_-_85895295 Show fit	2.18	ENST00000428225.1 ENST00000519937.2	SFTPB Ensembl NCBI GeneCards UniProt NextProt Show fit	surfactant protein B
chr12_-_45270151 Show fit	2.08	ENST00000429094.2	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)
chr10_+_81370689 Show fit	2.07	ENST00000372308.3 ENST00000398636.3 ENST00000428376.2 ENST00000372313.5 ENST00000419470.2 ENST00000429958.1 ENST00000439264.1	SFTPA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	surfactant protein A1
chr6_+_17102489 Show fit	2.00	ENST00000536551.1	STMND1 Ensembl NCBI GeneCards UniProt NextProt Show fit	stathmin domain containing 1
chr15_+_81591757 Show fit	1.93	ENST00000558332.1	IL16 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 16

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GLI3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.4	GO:0006910	phagocytosis, recognition(GO:0006910)
0.3	6.6	GO:0036158	outer dynein arm assembly(GO:0036158)
0.3	5.5	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	3.8	GO:0006958	complement activation, classical pathway(GO:0006958)
0.2	3.7	GO:0060294	cilium movement involved in cell motility(GO:0060294)
0.4	3.4	GO:0046469	platelet activating factor metabolic process(GO:0046469)
0.1	3.0	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.5	2.9	GO:0045918	negative regulation of cytolysis(GO:0045918)
0.0	2.8	GO:0001895	retina homeostasis(GO:0001895)
0.1	2.5	GO:1901741	positive regulation of myoblast fusion(GO:1901741)

Showing 1 to 10 of 370 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.2	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	7.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	6.7	GO:0042599	lamellar body(GO:0042599)
0.4	5.3	GO:0036157	outer dynein arm(GO:0036157)
0.1	5.2	GO:0001772	immunological synapse(GO:0001772)
0.0	4.5	GO:0036126	sperm flagellum(GO:0036126)
0.0	4.1	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0	3.4	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	2.2	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	2.2	GO:0005814	centriole(GO:0005814)

Showing 1 to 10 of 123 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.2	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	7.1	GO:0003823	antigen binding(GO:0003823)
0.2	5.0	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	4.5	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.3	3.4	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	3.3	GO:0005125	cytokine activity(GO:0005125)
0.1	3.2	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.5	3.0	GO:0019828	aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1	2.8	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	2.7	GO:0008083	growth factor activity(GO:0008083)

Showing 1 to 10 of 251 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	7.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	3.9	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	3.9	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	3.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	3.0	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	2.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	2.5	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	2.4	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	2.2	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins

Showing 1 to 10 of 64 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.0	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.2	3.7	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1	3.4	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1	3.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	3.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	2.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	2.5	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.1	2.0	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	2.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	2.0	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development

Showing 1 to 10 of 70 entries

Results for GLI3

Z-value: 1.86

Motif logo

Transcription factors associated with GLI3

Activity-expression correlation:

Activity profile of GLI3 motif

Sorted Z-values of GLI3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GLI3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: