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Illumina Body Map 2: averaged replicates

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Results for GRHL1

Z-value: 2.02

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.13 grainyhead like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg19_v2_chr2_+_10091783_100918110.691.5e-05Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_61002584 8.63 ENST00000252998.1
RBBP8NL
RBBP8 N-terminal like
chr20_-_18038521 6.69 ENST00000278780.6
OVOL2
ovo-like zinc finger 2
chr1_-_201368707 5.88 ENST00000391967.2
LAD1
ladinin 1
chr2_+_95940220 5.78 ENST00000542147.1
PROM2
prominin 2
chr1_-_201368653 5.46 ENST00000367313.3
LAD1
ladinin 1
chr11_+_706595 5.11 ENST00000531348.1
ENST00000530636.1
EPS8L2
EPS8-like 2
chr11_+_76493294 4.52 ENST00000533752.1
TSKU
tsukushi, small leucine rich proteoglycan
chr19_+_45312310 4.41 ENST00000589651.1
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr8_+_144821557 4.03 ENST00000534398.1
FAM83H-AS1
FAM83H antisense RNA 1 (head to head)
chr2_+_95940186 3.89 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
PROM2
prominin 2
chr19_+_45312347 3.47 ENST00000270233.6
ENST00000591520.1
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr3_-_58643483 3.28 ENST00000483787.1
FAM3D
family with sequence similarity 3, member D
chr3_-_58643458 3.00 ENST00000498347.1
FAM3D
family with sequence similarity 3, member D
chr19_+_1491144 2.84 ENST00000233596.3
REEP6
receptor accessory protein 6
chr19_-_291133 2.80 ENST00000327790.3
PPAP2C
phosphatidic acid phosphatase type 2C
chr12_+_18414446 2.78 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr1_-_24469602 2.69 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr13_+_34922173 2.27 ENST00000605909.1
RP11-16D22.2
RP11-16D22.2
chr11_-_14992712 2.26 ENST00000486207.1
CALCA
calcitonin-related polypeptide alpha
chr11_-_67442079 2.23 ENST00000349015.3
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr3_+_186383741 2.21 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr5_+_134303591 2.19 ENST00000282611.6
CATSPER3
cation channel, sperm associated 3
chr7_-_80551671 1.99 ENST00000419255.2
ENST00000544525.1
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_+_210406121 1.84 ENST00000367012.3
SERTAD4
SERTA domain containing 4
chr1_+_35247859 1.64 ENST00000373362.3
GJB3
gap junction protein, beta 3, 31kDa
chr6_-_46889694 1.62 ENST00000283296.7
ENST00000362015.4
ENST00000456426.2
GPR116
G protein-coupled receptor 116
chr5_+_125758813 1.54 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr5_+_125758865 1.48 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr11_-_67442196 1.41 ENST00000525827.1
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr19_-_11849697 1.32 ENST00000586121.1
ENST00000431998.1
ENST00000341191.6
ENST00000545749.1
ENST00000440527.1
ZNF823
zinc finger protein 823
chr9_+_140122018 1.27 ENST00000445101.2
RNF224
ring finger protein 224
chr18_-_55470320 1.20 ENST00000536015.1
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr17_+_9728828 1.19 ENST00000262441.5
GLP2R
glucagon-like peptide 2 receptor
chr6_+_168227611 1.18 ENST00000344191.4
ENST00000351017.4
ENST00000392108.3
ENST00000366806.2
ENST00000392112.1
ENST00000400824.4
ENST00000447894.2
ENST00000400822.3
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr4_-_110736505 1.16 ENST00000609440.1
RP11-602N24.3
RP11-602N24.3
chr6_-_31107127 1.13 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr11_+_15095108 0.98 ENST00000324229.6
ENST00000533448.1
CALCB
calcitonin-related polypeptide beta
chr2_-_209118974 0.97 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr5_+_125759140 0.95 ENST00000543198.1
GRAMD3
GRAM domain containing 3
chr1_-_153113927 0.95 ENST00000368752.4
SPRR2B
small proline-rich protein 2B
chr12_+_49687425 0.94 ENST00000257860.4
PRPH
peripherin
chr1_-_234667504 0.94 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr19_-_12405606 0.77 ENST00000356109.5
ZNF44
zinc finger protein 44
chr19_-_35981358 0.76 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr4_+_110736659 0.66 ENST00000394631.3
ENST00000226796.6
GAR1
GAR1 ribonucleoprotein
chr19_-_12405689 0.65 ENST00000355684.5
ZNF44
zinc finger protein 44
chr10_+_81838792 0.63 ENST00000372273.3
TMEM254
transmembrane protein 254
chr6_+_168227552 0.63 ENST00000400825.4
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chrX_+_146993449 0.61 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
FMR1
fragile X mental retardation 1
chr19_-_12146483 0.60 ENST00000455504.2
ENST00000547560.1
ENST00000552904.1
ENST00000419886.2
ENST00000550507.1
ENST00000344980.6
ENST00000550745.1
ENST00000411841.1
ZNF433
zinc finger protein 433
chr21_+_33671160 0.55 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr2_-_190446738 0.47 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr19_-_17356697 0.46 ENST00000291442.3
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr10_+_105036909 0.46 ENST00000369849.4
INA
internexin neuronal intermediate filament protein, alpha
chr18_+_44497455 0.46 ENST00000592005.1
KATNAL2
katanin p60 subunit A-like 2
chr10_+_81838411 0.45 ENST00000372281.3
ENST00000372277.3
ENST00000372275.1
ENST00000372274.1
TMEM254
transmembrane protein 254
chr19_-_15590306 0.42 ENST00000292609.4
PGLYRP2
peptidoglycan recognition protein 2
chr4_-_99850243 0.40 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
EIF4E
eukaryotic translation initiation factor 4E
chr11_-_93583697 0.38 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr4_-_69083720 0.37 ENST00000432593.3
TMPRSS11BNL
TMPRSS11B N-terminal like
chr19_-_14945933 0.35 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr20_-_54967187 0.34 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chr10_+_96443204 0.34 ENST00000339022.5
CYP2C18
cytochrome P450, family 2, subfamily C, polypeptide 18
chr18_-_35145728 0.33 ENST00000361795.5
ENST00000603232.1
CELF4
CUGBP, Elav-like family member 4
chr19_+_12035878 0.33 ENST00000254321.5
ENST00000538752.1
ENST00000590798.1
ZNF700
ZNF763
ZNF763
zinc finger protein 700
zinc finger protein 763
Uncharacterized protein; Zinc finger protein 763
chr16_-_23568651 0.31 ENST00000563232.1
ENST00000563459.1
ENST00000449606.1
EARS2
glutamyl-tRNA synthetase 2, mitochondrial
chr6_-_43027105 0.27 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chr3_-_172241250 0.26 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr15_+_49170083 0.26 ENST00000530028.2
EID1
EP300 interacting inhibitor of differentiation 1
chr20_-_25320367 0.24 ENST00000450393.1
ENST00000491682.1
ABHD12
abhydrolase domain containing 12
chr9_+_71736177 0.22 ENST00000606364.1
ENST00000453658.2
TJP2
tight junction protein 2
chr12_+_118814185 0.21 ENST00000543473.1
SUDS3
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr1_+_44440575 0.21 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr18_+_20494078 0.20 ENST00000579124.1
ENST00000577588.1
ENST00000582354.1
ENST00000581819.1
RBBP8
retinoblastoma binding protein 8
chr6_+_32121218 0.19 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
PPT2
palmitoyl-protein thioesterase 2
chr4_-_129209944 0.18 ENST00000520121.1
PGRMC2
progesterone receptor membrane component 2
chr14_+_23938891 0.18 ENST00000408901.3
ENST00000397154.3
ENST00000555128.1
NGDN
neuroguidin, EIF4E binding protein
chr18_+_12093838 0.17 ENST00000587848.2
ANKRD62
ankyrin repeat domain 62
chr19_+_12035913 0.15 ENST00000591944.1
ZNF763
Uncharacterized protein; Zinc finger protein 763
chr1_-_16539094 0.13 ENST00000270747.3
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr1_+_40723779 0.09 ENST00000372759.3
ZMPSTE24
zinc metallopeptidase STE24
chr12_-_10959892 0.09 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr9_-_77703115 0.08 ENST00000361092.4
ENST00000376808.4
NMRK1
nicotinamide riboside kinase 1
chr22_+_18560675 0.07 ENST00000329627.7
PEX26
peroxisomal biogenesis factor 26
chr8_+_22601 0.05 ENST00000522481.3
ENST00000518652.1
AC144568.2
Uncharacterized protein
chr19_-_40596767 0.03 ENST00000599972.1
ENST00000450241.2
ENST00000595687.2
ZNF780A
zinc finger protein 780A
chr14_-_80677815 0.03 ENST00000557125.1
ENST00000555750.1
DIO2
deiodinase, iodothyronine, type II

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.7 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
1.1 4.5 GO:0061073 ciliary body morphogenesis(GO:0061073)
1.1 6.7 GO:0060214 endocardium formation(GO:0060214)
0.8 2.3 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.6 2.2 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.3 5.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.3 1.0 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 1.2 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.2 0.7 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2 0.6 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
0.2 2.0 GO:0003350 pulmonary myocardium development(GO:0003350)
0.2 0.5 GO:1903414 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.1 0.4 GO:0032827 negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.1 3.6 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.3 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.1 0.3 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.1 6.3 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 2.8 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.2 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 2.8 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 2.2 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.2 GO:0071684 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.5 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.1 GO:0080120 prenylated protein catabolic process(GO:0030327) CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.0 2.7 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.5 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 1.2 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.2 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 1.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.3 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 6.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.9 GO:0018149 peptide cross-linking(GO:0018149)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.7 GO:0044393 microspike(GO:0044393)
0.2 2.2 GO:0036128 CatSper complex(GO:0036128)
0.2 0.6 GO:1902737 dendritic filopodium(GO:1902737)
0.1 0.7 GO:0090661 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.1 2.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.2 GO:0036019 endolysosome(GO:0036019)
0.1 11.3 GO:0005604 basement membrane(GO:0005604)
0.0 0.5 GO:0005883 neurofilament(GO:0005883)
0.0 2.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 3.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.8 GO:0042599 lamellar body(GO:0042599)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 5.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.2 GO:0032420 stereocilium(GO:0032420)
0.0 0.4 GO:0033391 chromatoid body(GO:0033391)
0.0 2.3 GO:0043195 terminal bouton(GO:0043195)
0.0 6.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.9 GO:0001533 cornified envelope(GO:0001533)
0.0 1.0 GO:1904724 tertiary granule lumen(GO:1904724)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0005055 laminin receptor activity(GO:0005055)
0.6 2.3 GO:0031716 calcitonin receptor binding(GO:0031716)
0.4 2.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.3 1.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 1.2 GO:0004967 glucagon receptor activity(GO:0004967)
0.3 2.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 3.6 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 0.5 GO:0097689 iron channel activity(GO:0097689)
0.1 9.7 GO:0015485 cholesterol binding(GO:0015485)
0.1 5.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.3 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.1 0.4 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 1.2 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.6 GO:0034046 poly(G) binding(GO:0034046)
0.1 2.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.3 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.1 1.6 GO:0005243 gap junction channel activity(GO:0005243)
0.1 2.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.7 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 2.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.1 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 1.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.0 6.3 GO:0005125 cytokine activity(GO:0005125)
0.0 10.8 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 2.8 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 4.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 2.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 4.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 1.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.7 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport