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Illumina Body Map 2: averaged replicates
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Results for GTF2I
Z-value: 2.74
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Transcription factors associated with GTF2I
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2I | hg19_v2_chr7_+_74072288_74072357 | 0.25 | 1.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_203444887 Show fit | 6.73 |
ENST00000343110.2
|
proline/arginine-rich end leucine-rich repeat protein |
|
| chr14_+_24837226 Show fit | 6.17 |
ENST00000554050.1
ENST00000554903.1 ENST00000554779.1 ENST00000250373.4 ENST00000553708.1 |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
|
| chr12_-_16759440 Show fit | 4.34 |
ENST00000537304.1
|
LIM domain only 3 (rhombotin-like 2) |
|
| chr12_+_13044787 Show fit | 4.16 |
ENST00000534831.1
|
G protein-coupled receptor, family C, group 5, member A |
|
| chr9_-_34589734 Show fit | 3.93 |
ENST00000378980.3
|
ciliary neurotrophic factor receptor |
|
| chr12_-_16759711 Show fit | 3.74 |
ENST00000447609.1
|
LIM domain only 3 (rhombotin-like 2) |
|
| chr11_+_125034586 Show fit | 3.74 |
ENST00000298282.9
|
PBX/knotted 1 homeobox 2 |
|
| chr9_-_34589700 Show fit | 3.60 |
ENST00000351266.4
|
ciliary neurotrophic factor receptor |
|
| chr14_-_61191049 Show fit | 3.35 |
ENST00000556952.3
|
SIX homeobox 4 |
|
| chr11_+_125034640 Show fit | 3.29 |
ENST00000542175.1
|
PBX/knotted 1 homeobox 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GTF2I
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 16.8 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.3 | 11.9 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 1.0 | 10.5 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 1.4 | 9.7 | GO:0072180 | mesonephric duct morphogenesis(GO:0072180) |
| 0.8 | 9.1 | GO:0070120 | ciliary neurotrophic factor-mediated signaling pathway(GO:0070120) |
| 0.0 | 8.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 8.2 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.1 | 8.1 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 1.6 | 7.8 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.1 | 7.6 | GO:0008542 | visual learning(GO:0008542) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 47.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 16.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 12.2 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 1.1 | 12.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 11.3 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 9.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.9 | 9.5 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.2 | 9.3 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 8.0 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.2 | 7.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 13.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 11.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.8 | 10.9 | GO:0030274 | LIM domain binding(GO:0030274) |
| 2.1 | 10.5 | GO:0031751 | D4 dopamine receptor binding(GO:0031751) |
| 0.0 | 9.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.9 | 9.1 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
| 0.1 | 7.9 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 1.8 | 7.2 | GO:0060422 | peptidyl-dipeptidase inhibitor activity(GO:0060422) |
| 0.1 | 6.7 | GO:0003785 | actin monomer binding(GO:0003785) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 15.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 12.5 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 10.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 6.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 6.2 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 6.2 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 6.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 6.1 | PID SHP2 PATHWAY | SHP2 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 11.0 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 10.1 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 9.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 7.1 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.3 | 6.9 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.3 | 6.9 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.3 | 6.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 6.6 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 5.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |