ISMARA results: HBP1

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Illumina Body Map 2: averaged replicates

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Results for HBP1

Z-value: 1.71

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Transcription factors associated with HBP1

Gene Symbol	Gene ID	Gene Info
HBP1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000105856.9	HMG-box transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HBP1	hg19_v2_chr7_+_106809406_106809460	-0.30	9.5e-02	Click!

Activity profile of HBP1 motif

Sorted Z-values of HBP1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_4198072 Show fit	6.50	ENST00000262970.5	ANKRD24 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin repeat domain 24
chr2_+_231902193 Show fit	3.14	ENST00000373640.4	C2orf72 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 2 open reading frame 72
chr3_+_125985620 Show fit	2.58	ENST00000511512.1 ENST00000512435.1	RP11-71E19.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-71E19.1
chr1_-_85930246 Show fit	2.24	ENST00000426972.3	DDAH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dimethylarginine dimethylaminohydrolase 1
chr17_+_68071389 Show fit	2.24	ENST00000283936.1 ENST00000392671.1	KCNJ16 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071458 Show fit	2.05	ENST00000589377.1	KCNJ16 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 16
chr19_-_10697895 Show fit	2.04	ENST00000591240.1 ENST00000589684.1 ENST00000591676.1 ENST00000250244.6 ENST00000590923.1	AP1M2 Ensembl NCBI GeneCards UniProt NextProt Show fit	adaptor-related protein complex 1, mu 2 subunit
chr10_-_134756030 Show fit	2.02	ENST00000368586.5 ENST00000368582.2	TTC40 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetratricopeptide repeat domain 40
chr5_+_159656437 Show fit	2.02	ENST00000402432.3	FABP6 Ensembl NCBI GeneCards UniProt NextProt Show fit	fatty acid binding protein 6, ileal
chr5_-_147211226 Show fit	1.99	ENST00000296695.5	SPINK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serine peptidase inhibitor, Kazal type 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HBP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.7	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3	4.6	GO:1901748	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1	4.3	GO:0010107	potassium ion import(GO:0010107)
0.9	3.8	GO:2001248	nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.4	2.8	GO:0008218	bioluminescence(GO:0008218)
0.2	2.8	GO:0038044	transforming growth factor-beta secretion(GO:0038044)
0.1	2.2	GO:0006527	arginine catabolic process(GO:0006527)
0.1	2.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	2.2	GO:0019433	triglyceride catabolic process(GO:0019433)
0.1	2.1	GO:0071420	cellular response to histamine(GO:0071420)

Showing 1 to 10 of 109 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.7	GO:0030018	Z disc(GO:0030018)
0.0	5.6	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	4.3	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.1	3.8	GO:0005719	nuclear euchromatin(GO:0005719)
0.9	2.8	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.0	2.6	GO:0001669	acrosomal vesicle(GO:0001669)
0.1	2.1	GO:1902711	GABA-A receptor complex(GO:1902711)
0.0	2.0	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	2.0	GO:0005882	intermediate filament(GO:0005882)
0.0	1.8	GO:0043034	costamere(GO:0043034)

Showing 1 to 10 of 50 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.3	4.6	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.2	4.3	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.9	3.8	GO:1902122	chenodeoxycholic acid binding(GO:1902122)
0.0	3.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	2.8	GO:0001618	virus receptor activity(GO:0001618)
0.3	2.2	GO:0016403	dimethylargininase activity(GO:0016403)
0.2	2.2	GO:0030060	L-malate dehydrogenase activity(GO:0030060)
0.1	2.2	GO:0000400	four-way junction DNA binding(GO:0000400)
0.1	2.0	GO:0032052	bile acid binding(GO:0032052)

Showing 1 to 10 of 85 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	2.8	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	1.0	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.8	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	2.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	2.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	2.0	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	2.0	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	1.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	1.7	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.1	1.4	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	1.3	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.1	1.2	REACTOME XENOBIOTICS	Genes involved in Xenobiotics

Showing 1 to 10 of 31 entries

Results for HBP1

Z-value: 1.71

Motif logo

Transcription factors associated with HBP1

Activity-expression correlation:

Activity profile of HBP1 motif

Sorted Z-values of HBP1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HBP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: