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Illumina Body Map 2: averaged replicates
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Results for HESX1
Z-value: 2.23
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Transcription factors associated with HESX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HESX1 | hg19_v2_chr3_-_57233966_57234014 | -0.18 | 3.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_90198535 Show fit | 9.32 |
ENST00000390276.2
|
immunoglobulin kappa variable 1D-12 |
|
| chr2_-_89310012 Show fit | 8.96 |
ENST00000493819.1
|
immunoglobulin kappa variable 1-9 |
|
| chr2_-_89292422 Show fit | 8.55 |
ENST00000495489.1
|
immunoglobulin kappa variable 1-8 |
|
| chr14_-_106406090 Show fit | 8.49 |
ENST00000390593.2
|
immunoglobulin heavy variable 6-1 |
|
| chr2_-_89513402 Show fit | 8.02 |
ENST00000498435.1
|
immunoglobulin kappa variable 1-27 |
|
| chr2_+_90229045 Show fit | 7.89 |
ENST00000390278.2
|
immunoglobulin kappa variable 1D-42 (non-functional) |
|
| chr2_+_89952792 Show fit | 7.82 |
ENST00000390265.2
|
immunoglobulin kappa variable 1D-33 |
|
| chr2_+_90259593 Show fit | 7.54 |
ENST00000471857.1
|
immunoglobulin kappa variable 1D-8 |
|
| chr2_-_89568263 Show fit | 7.50 |
ENST00000473726.1
|
immunoglobulin kappa variable 1-33 |
|
| chr2_-_89399845 Show fit | 7.12 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HESX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 55.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 53.9 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.4 | 8.8 | GO:0034374 | low-density lipoprotein particle remodeling(GO:0034374) |
| 0.0 | 6.1 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 5.8 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.2 | 4.9 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 3.3 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.4 | 2.8 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
| 0.5 | 2.7 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.5 | 2.6 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 59.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 29.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 10.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 5.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.3 | 4.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 4.7 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.0 | 3.3 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 2.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 2.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.8 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 99.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 6.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.4 | 5.5 | GO:0017129 | triglyceride binding(GO:0017129) |
| 0.2 | 4.9 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 1.5 | 4.4 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.0 | 3.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.3 | 3.1 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.0 | 2.7 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 2.5 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.3 | 2.2 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 3.7 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 3.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 2.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 2.8 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 2.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.0 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 1.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 4.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 3.1 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 2.6 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 2.6 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 2.1 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.2 | 1.9 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 1.8 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.8 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 1.5 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |