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Illumina Body Map 2: averaged replicates
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Results for HIC1
Z-value: 2.27
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Transcription factors associated with HIC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC1 | hg19_v2_chr17_+_1958388_1958404 | -0.05 | 7.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.7 | 9.2 | GO:0036484 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) |
| 0.9 | 8.2 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
| 0.2 | 7.7 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.6 | 7.2 | GO:0060449 | bud elongation involved in lung branching(GO:0060449) |
| 0.7 | 7.1 | GO:0070100 | negative regulation of chemokine-mediated signaling pathway(GO:0070100) |
| 0.1 | 7.0 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.7 | 6.9 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 0.7 | 6.9 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.4 | 6.8 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 16.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 16.1 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.3 | 12.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 12.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 11.6 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.1 | 10.9 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 10.7 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.1 | 10.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 9.9 | GO:0043679 | axon terminus(GO:0043679) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.3 | 11.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 10.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 8.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.2 | 8.2 | GO:0031750 | D3 dopamine receptor binding(GO:0031750) |
| 0.3 | 8.0 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 8.0 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 7.5 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 7.4 | GO:0008201 | heparin binding(GO:0008201) |
| 1.2 | 6.9 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 14.3 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 12.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 11.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 10.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 9.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 7.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 6.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 6.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 6.3 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.4 | 11.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 10.0 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.2 | 7.6 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.2 | 6.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 6.6 | REACTOME SHC MEDIATED CASCADE | Genes involved in SHC-mediated cascade |
| 0.3 | 6.4 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 5.8 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 5.8 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 5.7 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |