Project
Illumina Body Map 2: averaged replicates
Navigation
Downloads
Results for HMX1
Z-value: 1.80
Motif logo
Transcription factors associated with HMX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMX1 | hg19_v2_chr4_-_8873531_8873543 | 0.07 | 6.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.0 | GO:0061152 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.1 | 5.6 | GO:0002279 | mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303) |
| 0.5 | 5.0 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 1.5 | 4.5 | GO:0002522 | leukocyte migration involved in immune response(GO:0002522) |
| 0.7 | 4.3 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.6 | 4.2 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
| 0.2 | 4.0 | GO:0002517 | T cell tolerance induction(GO:0002517) |
| 0.4 | 3.5 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.0 | 3.5 | GO:0030218 | erythrocyte differentiation(GO:0030218) |
| 0.1 | 3.4 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 7.0 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.4 | 6.0 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 4.8 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.3 | 4.3 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 4.3 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 4.0 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 3.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 3.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.4 | 3.0 | GO:0098536 | deuterosome(GO:0098536) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 6.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.3 | 6.0 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.0 | 5.2 | GO:0000988 | transcription factor activity, protein binding(GO:0000988) transcription factor activity, transcription factor binding(GO:0000989) |
| 0.0 | 4.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 3.5 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 3.5 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.2 | 3.1 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.3 | 2.9 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 2.9 | GO:0016805 | dipeptidase activity(GO:0016805) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 7.3 | PID EPO PATHWAY | EPO signaling pathway |
| 0.1 | 6.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.2 | 5.6 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 4.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 4.7 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 4.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 3.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.5 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 3.0 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.1 | 5.1 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.3 | 4.5 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.2 | 4.3 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 4.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 3.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 3.5 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 3.1 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 2.9 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 2.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |