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Illumina Body Map 2: averaged replicates
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Results for HMX3
Z-value: 1.69
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Transcription factors associated with HMX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMX3 | hg19_v2_chr10_+_124895472_124895508 | 0.33 | 6.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.9 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 7.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 7.2 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.2 | 4.6 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.1 | 4.4 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 4.2 | GO:0007411 | axon guidance(GO:0007411) |
| 0.2 | 3.9 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.0 | 3.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.3 | 3.7 | GO:0035766 | cell chemotaxis to fibroblast growth factor(GO:0035766) endothelial cell chemotaxis to fibroblast growth factor(GO:0035768) regulation of cell chemotaxis to fibroblast growth factor(GO:1904847) regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000544) |
| 0.1 | 3.7 | GO:1901687 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 9.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 9.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 7.8 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 5.5 | GO:0005902 | microvillus(GO:0005902) |
| 0.2 | 4.7 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 4.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 4.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 3.8 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 3.8 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 7.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.2 | 6.4 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 6.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 4.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.2 | 4.6 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 4.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 4.3 | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810) |
| 0.3 | 3.9 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 3.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 3.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.4 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 2.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 2.1 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.8 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.5 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 5.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 5.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 4.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 4.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 4.1 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 3.7 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.2 | 3.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 3.4 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 3.4 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |