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Illumina Body Map 2: averaged replicates

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Results for HNF1A_HNF1B

Z-value: 12.92

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol Gene ID Gene Info
HNF1A
ENSG00000135100.13 HNF1 homeobox A
HNF1B
ENSG00000108753.8 HNF1 homeobox B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v2_chr12_+_121416489_1214165520.841.4e-09Click!
HNF1Bhg19_v2_chr17_-_36105009_361050600.681.8e-05Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_72649763 137.34 ENST00000513476.1
GC
group-specific component (vitamin D binding protein)
chr4_+_74347400 115.09 ENST00000226355.3
AFM
afamin
chr17_-_64225508 102.94 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_+_155484103 90.69 ENST00000302068.4
FGB
fibrinogen beta chain
chr4_-_155511887 89.73 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr4_+_155484155 88.97 ENST00000509493.1
FGB
fibrinogen beta chain
chr19_-_36304201 87.29 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr2_+_234601512 73.28 ENST00000305139.6
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_234637754 71.68 ENST00000482026.1
ENST00000609767.1
UGT1A3
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr20_+_43029911 69.82 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4, alpha
chr6_+_161123270 68.94 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr1_-_159684371 68.58 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chrX_-_105282712 64.32 ENST00000372563.1
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr14_-_57960456 61.34 ENST00000534126.1
ENST00000422976.2
C14orf105
chromosome 14 open reading frame 105
chr14_-_57960545 60.47 ENST00000526336.1
ENST00000216445.3
C14orf105
chromosome 14 open reading frame 105
chr4_+_187187098 59.98 ENST00000403665.2
ENST00000264692.4
F11
coagulation factor XI
chr2_+_234668894 57.25 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UGT1A8
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr1_+_207277590 55.48 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr20_-_7921090 54.82 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr1_-_204183071 53.33 ENST00000308302.3
GOLT1A
golgi transport 1A
chr1_+_207277632 52.98 ENST00000421786.1
C4BPA
complement component 4 binding protein, alpha
chr4_-_69817481 52.69 ENST00000251566.4
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr20_+_42984330 52.38 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
HNF4A
hepatocyte nuclear factor 4, alpha
chr20_+_42187682 49.91 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr5_+_175976324 47.48 ENST00000261944.5
CDHR2
cadherin-related family member 2
chr7_-_50633078 47.17 ENST00000444124.2
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr4_+_74269956 46.91 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB
albumin
chr10_+_115312825 46.27 ENST00000537906.1
ENST00000541666.1
HABP2
hyaluronan binding protein 2
chrX_-_15683147 43.79 ENST00000380342.3
TMEM27
transmembrane protein 27
chr9_-_123812542 43.60 ENST00000223642.1
C5
complement component 5
chr14_-_94759361 42.78 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759408 42.41 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr10_+_101542462 41.52 ENST00000370449.4
ENST00000370434.1
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr15_+_58724184 41.47 ENST00000433326.2
LIPC
lipase, hepatic
chr14_-_94759595 41.27 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_-_88427568 41.25 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chr4_+_187187337 41.14 ENST00000492972.2
F11
coagulation factor XI
chr8_-_17752996 40.85 ENST00000381841.2
ENST00000427924.1
FGL1
fibrinogen-like 1
chr3_+_186383741 40.83 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr2_+_88047606 39.56 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr14_-_94854926 39.50 ENST00000402629.1
ENST00000556091.1
ENST00000554720.1
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_-_197036364 38.87 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr6_-_161085291 38.74 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr6_+_25754927 38.62 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr5_+_176513868 38.40 ENST00000292408.4
FGFR4
fibroblast growth factor receptor 4
chr20_+_42187608 38.25 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr17_+_4692230 37.14 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr6_-_25930819 36.53 ENST00000360488.3
SLC17A2
solute carrier family 17, member 2
chr2_+_234621551 36.12 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr6_-_25930904 36.08 ENST00000377850.3
SLC17A2
solute carrier family 17, member 2
chr2_+_27719697 36.03 ENST00000264717.2
ENST00000424318.2
GCKR
glucokinase (hexokinase 4) regulator
chr10_+_115312766 36.00 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr19_+_11350278 35.55 ENST00000252453.8
C19orf80
chromosome 19 open reading frame 80
chr4_-_110723335 34.07 ENST00000394634.2
CFI
complement factor I
chr2_+_234526272 33.43 ENST00000373450.4
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr12_+_100867486 32.91 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr16_+_20462783 32.76 ENST00000574251.1
ENST00000576361.1
ENST00000417235.2
ENST00000573854.1
ENST00000424070.1
ENST00000536134.1
ENST00000219054.6
ENST00000575690.1
ENST00000571894.1
ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chr16_+_20775358 32.59 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr4_+_3443614 32.56 ENST00000382774.3
ENST00000511533.1
HGFAC
HGF activator
chr9_-_116861337 32.48 ENST00000374118.3
KIF12
kinesin family member 12
chr2_+_234627424 32.34 ENST00000373409.3
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr4_-_110723194 31.93 ENST00000394635.3
CFI
complement factor I
chr16_-_20587599 31.36 ENST00000566384.1
ENST00000565232.1
ENST00000567001.1
ENST00000565322.1
ENST00000569344.1
ENST00000329697.6
ENST00000414188.2
ENST00000568882.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr4_-_110723134 31.12 ENST00000510800.1
ENST00000512148.1
CFI
complement factor I
chr17_+_41052808 31.06 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC
glucose-6-phosphatase, catalytic subunit
chr12_+_100867694 31.03 ENST00000392986.3
ENST00000549996.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr5_+_176513895 30.79 ENST00000503708.1
ENST00000393648.2
ENST00000514472.1
ENST00000502906.1
ENST00000292410.3
ENST00000510911.1
FGFR4
fibroblast growth factor receptor 4
chr10_+_135340859 30.67 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr1_+_63063152 30.56 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr16_+_20775024 30.36 ENST00000289416.5
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr6_-_51952418 29.63 ENST00000371117.3
PKHD1
polycystic kidney and hepatic disease 1 (autosomal recessive)
chr17_+_73642315 29.58 ENST00000556126.2
SMIM6
small integral membrane protein 6
chr6_-_25874440 29.04 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr11_-_117695449 28.74 ENST00000292079.2
FXYD2
FXYD domain containing ion transport regulator 2
chr7_-_44580861 28.69 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr17_+_73642486 28.30 ENST00000579469.1
SMIM6
small integral membrane protein 6
chr7_+_45927956 28.14 ENST00000275525.3
ENST00000457280.1
IGFBP1
insulin-like growth factor binding protein 1
chr5_+_176514413 27.92 ENST00000513166.1
FGFR4
fibroblast growth factor receptor 4
chr6_+_50061315 25.65 ENST00000415106.1
RP11-397G17.1
RP11-397G17.1
chr4_+_100495864 25.60 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr8_-_124749609 25.32 ENST00000262219.6
ENST00000419625.1
ANXA13
annexin A13
chr1_+_57320437 25.07 ENST00000361249.3
C8A
complement component 8, alpha polypeptide
chr2_-_87248975 24.89 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr6_-_52628271 24.60 ENST00000493422.1
GSTA2
glutathione S-transferase alpha 2
chr7_+_45928079 24.47 ENST00000468955.1
IGFBP1
insulin-like growth factor binding protein 1
chr12_+_100867733 24.01 ENST00000546380.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr1_+_55505184 24.01 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr1_+_18807424 23.86 ENST00000400664.1
KLHDC7A
kelch domain containing 7A
chr1_-_20141763 23.70 ENST00000375121.2
RNF186
ring finger protein 186
chr11_+_64323098 23.58 ENST00000301891.4
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr16_-_69385681 23.22 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr14_+_95027772 22.80 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr12_+_100897130 22.66 ENST00000551379.1
ENST00000188403.7
ENST00000551184.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr11_-_111649074 22.51 ENST00000534218.1
RP11-108O10.2
RP11-108O10.2
chr1_+_119911425 22.47 ENST00000361035.4
ENST00000325945.3
HAO2
hydroxyacid oxidase 2 (long chain)
chr21_-_47575481 22.44 ENST00000291670.5
ENST00000397748.1
ENST00000359679.2
ENST00000355384.2
ENST00000397746.3
ENST00000397743.1
FTCD
formimidoyltransferase cyclodeaminase
chr15_+_48498480 21.95 ENST00000380993.3
ENST00000396577.3
SLC12A1
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr17_+_1646130 21.87 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr4_+_74301880 21.55 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr14_-_65409438 21.51 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr14_-_65409502 21.33 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_+_169013666 20.84 ENST00000359299.3
ANXA10
annexin A10
chr4_-_69434245 20.50 ENST00000317746.2
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr1_+_207262170 20.34 ENST00000367078.3
C4BPB
complement component 4 binding protein, beta
chr11_+_46740730 19.84 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2
coagulation factor II (thrombin)
chr2_+_133174147 19.08 ENST00000329321.3
GPR39
G protein-coupled receptor 39
chr7_-_155601766 18.13 ENST00000430104.1
SHH
sonic hedgehog
chr10_+_45406627 18.10 ENST00000389583.4
TMEM72
transmembrane protein 72
chr11_+_64323156 18.07 ENST00000377585.3
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr11_-_26744908 18.04 ENST00000533617.1
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr10_+_5135981 18.01 ENST00000380554.3
AKR1C3
aldo-keto reductase family 1, member C3
chr14_+_21156915 17.93 ENST00000397990.4
ENST00000555597.1
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr10_+_99344071 17.41 ENST00000370647.4
ENST00000370646.4
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr1_+_119911396 17.27 ENST00000457318.1
HAO2
hydroxyacid oxidase 2 (long chain)
chr3_-_74570291 17.09 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr10_-_52645416 16.66 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr12_+_21284118 16.42 ENST00000256958.2
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr6_-_51952367 16.19 ENST00000340994.4
PKHD1
polycystic kidney and hepatic disease 1 (autosomal recessive)
chr5_-_138718973 15.69 ENST00000353963.3
ENST00000348729.3
SLC23A1
solute carrier family 23 (ascorbic acid transporter), member 1
chr1_+_207262578 15.63 ENST00000243611.5
ENST00000367076.3
C4BPB
complement component 4 binding protein, beta
chr12_+_20963632 15.35 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr3_-_169587621 15.19 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr1_+_207262627 14.58 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr12_+_20963647 14.53 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr15_-_99057551 14.32 ENST00000558256.1
FAM169B
family with sequence similarity 169, member B
chr16_+_82068873 14.04 ENST00000566213.1
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_-_987217 13.42 ENST00000361661.2
ENST00000398516.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr16_+_82068585 13.29 ENST00000563491.1
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr10_-_61495760 12.80 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr6_+_54173227 12.62 ENST00000259782.4
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr16_+_21244986 12.47 ENST00000311620.5
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr11_+_560956 12.46 ENST00000397582.3
ENST00000344375.4
ENST00000397583.3
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr16_-_66952742 12.34 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
CDH16
cadherin 16, KSP-cadherin
chr16_-_66952779 12.32 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
CDH16
cadherin 16, KSP-cadherin
chr6_-_154751629 12.26 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr17_+_26800296 12.07 ENST00000444914.3
ENST00000314669.5
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr15_+_58430368 11.83 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr5_-_35195338 11.82 ENST00000509839.1
PRLR
prolactin receptor
chr10_-_52645379 11.81 ENST00000395489.2
A1CF
APOBEC1 complementation factor
chr4_+_39408470 11.72 ENST00000257408.4
KLB
klotho beta
chr16_-_55909255 11.62 ENST00000290567.9
CES5A
carboxylesterase 5A
chr6_+_54172653 11.47 ENST00000370869.3
TINAG
tubulointerstitial nephritis antigen
chr16_-_55909272 11.40 ENST00000319165.9
CES5A
carboxylesterase 5A
chr15_+_58430567 11.06 ENST00000536493.1
AQP9
aquaporin 9
chr19_+_6464243 10.96 ENST00000600229.1
ENST00000356762.3
CRB3
crumbs homolog 3 (Drosophila)
chr1_+_162351503 10.96 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr16_-_55909211 10.90 ENST00000520435.1
CES5A
carboxylesterase 5A
chr16_-_87970122 10.70 ENST00000309893.2
CA5A
carbonic anhydrase VA, mitochondrial
chr4_-_69536346 10.46 ENST00000338206.5
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr17_+_68071389 10.43 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_-_150020750 10.28 ENST00000539352.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr17_-_202579 10.16 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
RPH3AL
rabphilin 3A-like (without C2 domains)
chr2_-_99917639 10.13 ENST00000308528.4
LYG1
lysozyme G-like 1
chr3_-_157221128 10.02 ENST00000392833.2
ENST00000362010.2
VEPH1
ventricular zone expressed PH domain-containing 1
chr6_+_167704798 10.01 ENST00000230256.3
UNC93A
unc-93 homolog A (C. elegans)
chr17_+_68071458 9.79 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr14_+_39703112 9.74 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr11_+_64358686 9.58 ENST00000473690.1
SLC22A12
solute carrier family 22 (organic anion/urate transporter), member 12
chr4_-_100212132 9.49 ENST00000209668.2
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr6_+_167704838 9.25 ENST00000366829.2
UNC93A
unc-93 homolog A (C. elegans)
chr19_+_6464502 9.22 ENST00000308243.7
CRB3
crumbs homolog 3 (Drosophila)
chr16_+_81272287 9.06 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr2_+_38177575 8.58 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr7_-_150020814 8.44 ENST00000477871.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr9_-_98079965 8.12 ENST00000289081.3
FANCC
Fanconi anemia, complementation group C
chr1_-_153585539 8.10 ENST00000368706.4
S100A16
S100 calcium binding protein A16
chr17_-_26733604 7.87 ENST00000584426.1
ENST00000584995.1
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr7_-_104567066 7.87 ENST00000453666.1
RP11-325F22.5
RP11-325F22.5
chr3_+_72200408 7.80 ENST00000473713.1
LINC00870
long intergenic non-protein coding RNA 870
chr16_+_20911174 7.78 ENST00000568663.1
LYRM1
LYR motif containing 1
chr11_-_26743546 7.78 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr7_-_150020578 7.69 ENST00000478393.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr22_-_38506619 7.62 ENST00000332536.5
ENST00000381669.3
BAIAP2L2
BAI1-associated protein 2-like 2
chr17_+_26800648 7.56 ENST00000545060.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr11_+_64358722 7.37 ENST00000336464.7
SLC22A12
solute carrier family 22 (organic anion/urate transporter), member 12
chr17_+_26800756 7.15 ENST00000537681.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr18_-_48346415 7.11 ENST00000431965.2
ENST00000436348.2
MRO
maestro
chr14_+_39703084 6.99 ENST00000553728.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr4_-_1166954 6.98 ENST00000514490.1
ENST00000431380.1
ENST00000503765.1
SPON2
spondin 2, extracellular matrix protein
chr2_+_182850551 6.95 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr2_-_162931052 6.77 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr4_+_71494461 6.67 ENST00000396073.3
ENAM
enamelin
chr21_+_39628852 6.34 ENST00000398938.2
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr5_+_73109339 6.28 ENST00000296799.4
ARHGEF28
Rho guanine nucleotide exchange factor (GEF) 28
chrX_-_124097620 6.24 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr22_+_32439019 6.19 ENST00000266088.4
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr4_+_159442878 5.98 ENST00000307765.5
ENST00000423548.1
RXFP1
relaxin/insulin-like family peptide receptor 1
chr7_-_27219632 5.98 ENST00000470747.4
RP1-170O19.20
Uncharacterized protein
chr13_+_96085847 5.93 ENST00000376873.3
CLDN10
claudin 10
chr10_-_72648541 5.88 ENST00000299299.3
PCBD1
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr12_+_100750846 5.67 ENST00000323346.5
SLC17A8
solute carrier family 17 (vesicular glutamate transporter), member 8
chr21_+_39628780 5.56 ENST00000417042.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr2_+_21444025 5.55 ENST00000435237.1
ENST00000457901.1
AC067959.1
AC067959.1
chr4_-_987164 5.31 ENST00000398520.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr12_-_102874102 5.25 ENST00000392905.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_+_159443090 5.22 ENST00000343542.5
ENST00000470033.1
RXFP1
relaxin/insulin-like family peptide receptor 1
chr4_+_8201091 5.06 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr21_+_39628655 5.05 ENST00000398925.1
ENST00000398928.1
ENST00000328656.4
ENST00000443341.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr4_+_159443024 4.90 ENST00000448688.2
RXFP1
relaxin/insulin-like family peptide receptor 1
chr22_-_30970560 4.86 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
39.7 198.5 GO:0070980 biphenyl catabolic process(GO:0070980)
34.0 170.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
32.3 32.3 GO:0006789 bilirubin conjugation(GO:0006789)
27.7 110.6 GO:2001248 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
19.7 276.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
18.1 126.5 GO:0008218 bioluminescence(GO:0008218)
16.3 162.7 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
16.2 97.1 GO:1903412 response to bile acid(GO:1903412)
15.8 47.5 GO:0090675 intermicrovillar adhesion(GO:0090675)
15.7 47.2 GO:0052314 phytoalexin metabolic process(GO:0052314)
15.6 46.9 GO:0052331 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
14.8 44.4 GO:0016999 antibiotic metabolic process(GO:0016999)
14.3 185.5 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
12.5 87.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
12.2 122.2 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
10.5 73.3 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
8.8 70.2 GO:0009441 glycolate metabolic process(GO:0009441)
8.7 17.4 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
8.0 24.0 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
7.6 167.5 GO:0046415 urate metabolic process(GO:0046415)
7.3 43.6 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
7.0 83.8 GO:0052695 cellular glucuronidation(GO:0052695)
6.2 80.7 GO:0070327 thyroid hormone transport(GO:0070327)
6.0 18.1 GO:0060738 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
6.0 18.0 GO:2000224 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
5.3 68.6 GO:0008228 opsonization(GO:0008228)
5.2 15.7 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
5.1 30.7 GO:0010193 response to ozone(GO:0010193)
4.6 22.9 GO:0015722 canalicular bile acid transport(GO:0015722)
4.4 30.6 GO:0055091 phospholipid homeostasis(GO:0055091)
4.2 266.5 GO:0051180 vitamin transport(GO:0051180)
3.8 80.2 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
3.8 22.8 GO:0061107 seminal vesicle development(GO:0061107)
3.7 118.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
3.2 22.4 GO:0043606 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
3.1 12.5 GO:1904106 protein localization to microvillus(GO:1904106)
3.0 17.9 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
3.0 32.8 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
2.7 43.8 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
2.4 41.3 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
2.3 25.6 GO:0034378 chylomicron assembly(GO:0034378)
2.2 6.7 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
2.2 28.5 GO:0016554 cytidine to uridine editing(GO:0016554)
1.9 18.7 GO:0034036 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
1.5 11.8 GO:0038161 prolactin signaling pathway(GO:0038161)
1.5 11.7 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
1.4 52.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
1.4 28.7 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
1.3 27.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
1.3 10.1 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
1.3 25.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.1 28.7 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
1.1 21.5 GO:0001542 ovulation from ovarian follicle(GO:0001542)
1.1 6.8 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
1.1 14.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
1.0 63.0 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.8 36.5 GO:0010107 potassium ion import(GO:0010107)
0.8 45.8 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.7 97.1 GO:0030449 regulation of complement activation(GO:0030449)
0.7 28.9 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.7 6.2 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.6 5.6 GO:0000023 maltose metabolic process(GO:0000023)
0.6 7.8 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.6 90.8 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.6 22.0 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.5 5.9 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.5 39.5 GO:0006953 acute-phase response(GO:0006953)
0.5 32.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.5 4.7 GO:0071896 protein localization to adherens junction(GO:0071896)
0.5 9.5 GO:0006069 ethanol oxidation(GO:0006069)
0.4 4.2 GO:0015747 urate transport(GO:0015747)
0.4 51.0 GO:1990748 cellular detoxification(GO:1990748)
0.3 4.6 GO:0015866 ADP transport(GO:0015866)
0.3 42.4 GO:0009062 fatty acid catabolic process(GO:0009062)
0.3 2.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.3 3.5 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.3 7.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 13.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 3.0 GO:0006538 glutamate catabolic process(GO:0006538)
0.2 31.4 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.2 20.2 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.2 11.0 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.2 3.7 GO:0038203 TORC2 signaling(GO:0038203)
0.2 5.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.2 18.9 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.2 3.0 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.2 5.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 10.7 GO:0006730 one-carbon metabolic process(GO:0006730)
0.2 6.2 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 10.2 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 22.0 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 5.4 GO:0048286 lung alveolus development(GO:0048286)
0.1 17.3 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.9 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.1 1.3 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 3.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.8 GO:0019471 4-hydroxyproline metabolic process(GO:0019471)
0.1 4.1 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.1 30.3 GO:0007018 microtubule-based movement(GO:0007018)
0.1 28.6 GO:0007596 blood coagulation(GO:0007596)
0.1 6.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 12.5 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.1 0.9 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 10.8 GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.0 5.7 GO:0051592 response to calcium ion(GO:0051592)
0.0 2.6 GO:0002292 T cell differentiation involved in immune response(GO:0002292)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 84.4 GO:0006508 proteolysis(GO:0006508)
0.0 2.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 15.2 GO:0016567 protein ubiquitination(GO:0016567)
0.0 2.7 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 2.6 GO:0007498 mesoderm development(GO:0007498)
0.0 1.1 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.5 GO:0043968 histone H2A acetylation(GO:0043968)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
23.7 332.1 GO:0005577 fibrinogen complex(GO:0005577)
10.3 93.0 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
9.5 47.5 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
9.5 28.5 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
8.3 198.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
7.0 125.7 GO:0031089 platelet dense granule lumen(GO:0031089)
6.9 68.7 GO:0005579 membrane attack complex(GO:0005579)
4.0 48.3 GO:0046581 intercellular canaliculus(GO:0046581)
2.6 17.9 GO:0032311 angiogenin-PRI complex(GO:0032311)
2.3 41.3 GO:0045179 apical cortex(GO:0045179)
2.2 22.4 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
2.2 110.6 GO:0005719 nuclear euchromatin(GO:0005719)
1.9 15.3 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
1.9 5.7 GO:0097451 glial limiting end-foot(GO:0097451)
1.8 461.1 GO:0072562 blood microparticle(GO:0072562)
1.8 45.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
1.5 143.2 GO:0031526 brush border membrane(GO:0031526)
1.4 41.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
1.3 38.7 GO:0034358 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
1.3 94.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.2 32.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
1.0 28.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.7 8.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.5 260.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.4 7.6 GO:0071439 clathrin complex(GO:0071439)
0.4 9.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.3 11.8 GO:0031904 endosome lumen(GO:0031904)
0.3 35.6 GO:0005871 kinesin complex(GO:0005871)
0.3 128.4 GO:0016324 apical plasma membrane(GO:0016324)
0.3 44.1 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.3 65.2 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.3 128.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 150.7 GO:0030133 transport vesicle(GO:0030133)
0.3 462.6 GO:0005615 extracellular space(GO:0005615)
0.2 150.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 23.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 84.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 9.0 GO:0005902 microvillus(GO:0005902)
0.1 3.7 GO:0031932 TORC2 complex(GO:0031932)
0.1 156.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 17.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.1 GO:0001739 sex chromatin(GO:0001739)
0.1 15.6 GO:0005886 plasma membrane(GO:0005886)
0.1 56.0 GO:0000139 Golgi membrane(GO:0000139)
0.1 1.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 1.8 GO:0005795 Golgi stack(GO:0005795)
0.1 0.7 GO:0000439 core TFIIH complex(GO:0000439)
0.1 7.8 GO:0030496 midbody(GO:0030496)
0.0 5.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 172.3 GO:0005576 extracellular region(GO:0005576)
0.0 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 23.9 GO:0005739 mitochondrion(GO:0005739)
0.0 52.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 151.8 GO:0005654 nucleoplasm(GO:0005654)
0.0 71.6 GO:0016021 integral component of membrane(GO:0016021)
0.0 7.7 GO:0005815 microtubule organizing center(GO:0005815)
0.0 7.1 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
45.8 137.3 GO:1902271 D3 vitamins binding(GO:1902271)
31.5 94.6 GO:0052852 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
28.8 115.1 GO:0008431 vitamin E binding(GO:0008431)
27.7 110.6 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
23.0 68.9 GO:1904854 proteasome core complex binding(GO:1904854)
21.8 87.3 GO:0004657 proline dehydrogenase activity(GO:0004657)
14.7 102.9 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
13.7 68.6 GO:0033265 choline binding(GO:0033265)
9.8 127.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
8.9 26.8 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
8.1 97.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
7.8 31.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
7.4 147.6 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
7.3 387.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
7.3 22.0 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
7.2 36.0 GO:0070095 fructose-6-phosphate binding(GO:0070095)
6.0 24.0 GO:0070326 very-low-density lipoprotein particle binding(GO:0034189) very-low-density lipoprotein particle receptor binding(GO:0070326)
6.0 18.0 GO:0047017 geranylgeranyl reductase activity(GO:0045550) prostaglandin-F synthase activity(GO:0047017)
5.9 41.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
5.2 15.7 GO:0008520 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
4.6 22.9 GO:0015254 glycerol channel activity(GO:0015254)
4.6 27.3 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
4.0 32.0 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
3.8 52.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
3.7 58.6 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
3.2 101.1 GO:0070008 serine-type exopeptidase activity(GO:0070008)
3.1 80.2 GO:0034185 apolipoprotein binding(GO:0034185)
3.0 169.1 GO:0005504 fatty acid binding(GO:0005504)
2.8 22.4 GO:0016841 ammonia-lyase activity(GO:0016841)
2.8 41.5 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
2.7 88.2 GO:0017081 chloride channel regulator activity(GO:0017081)
2.6 17.9 GO:0004522 ribonuclease A activity(GO:0004522)
2.5 17.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
2.3 11.7 GO:0008422 beta-glucosidase activity(GO:0008422)
2.3 22.8 GO:0032190 acrosin binding(GO:0032190)
2.0 18.1 GO:0043237 laminin-1 binding(GO:0043237)
2.0 11.8 GO:0004925 prolactin receptor activity(GO:0004925)
2.0 5.9 GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
1.9 11.2 GO:0015350 methotrexate transporter activity(GO:0015350)
1.8 16.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.8 291.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.5 37.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
1.5 30.6 GO:0004859 phospholipase inhibitor activity(GO:0004859)
1.3 30.7 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
1.3 116.9 GO:0005044 scavenger receptor activity(GO:0005044)
1.3 19.8 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.3 28.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
1.3 42.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.2 28.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
1.1 14.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
1.1 179.7 GO:0051087 chaperone binding(GO:0051087)
1.1 9.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
1.0 21.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.8 28.7 GO:0031489 myosin V binding(GO:0031489)
0.8 6.7 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.8 41.4 GO:0008009 chemokine activity(GO:0008009)
0.8 10.2 GO:0030274 LIM domain binding(GO:0030274)
0.8 3.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.7 25.1 GO:0001848 complement binding(GO:0001848)
0.7 47.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.6 11.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.6 7.8 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.6 5.6 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.6 10.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.6 10.1 GO:0003796 lysozyme activity(GO:0003796)
0.5 22.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 3.5 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.5 2.9 GO:0070573 metallodipeptidase activity(GO:0070573)
0.4 2.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 46.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 15.3 GO:0005158 insulin receptor binding(GO:0005158)
0.4 4.7 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.4 121.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 4.6 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.3 12.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.2 4.2 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.2 35.6 GO:0003777 microtubule motor activity(GO:0003777)
0.2 4.1 GO:0070513 death domain binding(GO:0070513)
0.2 21.2 GO:0005548 phospholipid transporter activity(GO:0005548)
0.2 2.9 GO:0031419 cobalamin binding(GO:0031419)
0.2 7.0 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.2 28.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 5.7 GO:0015172 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.2 62.0 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.9 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 3.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 24.1 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 1.2 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 0.8 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 11.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 93.9 GO:0003723 RNA binding(GO:0003723)
0.0 31.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 27.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.6 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 27.4 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 16.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 4.3 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 269.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
3.2 294.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.8 110.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
1.7 108.5 PID CD40 PATHWAY CD40/CD40L signaling
1.4 541.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.2 68.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.8 100.2 PID FGF PATHWAY FGF signaling pathway
0.8 72.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.7 16.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.4 42.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 42.3 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.3 35.0 PID E2F PATHWAY E2F transcription factor network
0.2 8.1 PID BARD1 PATHWAY BARD1 signaling events
0.2 54.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 11.8 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 41.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 3.7 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
15.6 328.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
10.5 324.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
8.4 259.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
5.3 137.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
5.1 92.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
4.9 97.1 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
4.3 121.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
4.2 101.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
2.9 122.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
2.7 137.3 REACTOME STEROID HORMONES Genes involved in Steroid hormones
2.3 105.8 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
2.0 58.6 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
1.7 30.7 REACTOME XENOBIOTICS Genes involved in Xenobiotics
1.6 47.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
1.5 22.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
1.0 67.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.9 18.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.8 9.1 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.8 9.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.8 41.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.7 11.7 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.7 37.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.7 10.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.6 99.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.5 26.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.5 56.0 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.4 28.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.4 6.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 11.8 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.3 26.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 50.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 75.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 8.1 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.2 41.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 4.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 28.5 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.1 12.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 7.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 10.8 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.1 3.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 5.6 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 0.8 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 6.2 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 3.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases