ISMARA results: HNF4A

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Illumina Body Map 2: averaged replicates

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Results for HNF4A

Z-value: 4.86

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Transcription factors associated with HNF4A

Gene Symbol	Gene ID	Gene Info
HNF4A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000101076.12	hepatocyte nuclear factor 4 alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HNF4A	hg19_v2_chr20_+_42984330_42984445	0.83	2.9e-09	Click!

Activity profile of HNF4A motif

Sorted Z-values of HNF4A motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_96698406 Show fit	28.68	ENST00000260682.6	CYP2C9 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome P450, family 2, subfamily C, polypeptide 9
chr17_+_4675175 Show fit	24.03	ENST00000270560.3	TM4SF5 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane 4 L six family member 5
chr10_+_96522361 Show fit	23.86	ENST00000371321.3	CYP2C19 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome P450, family 2, subfamily C, polypeptide 19
chr10_-_96829246 Show fit	23.72	ENST00000371270.3 ENST00000535898.1 ENST00000539050.1	CYP2C8 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome P450, family 2, subfamily C, polypeptide 8
chr10_-_129691195 Show fit	23.41	ENST00000368671.3	CLRN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	clarin 3
chr5_-_35048047 Show fit	21.66	ENST00000231420.6	AGXT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	alanine--glyoxylate aminotransferase 2
chr6_+_30130969 Show fit	21.22	ENST00000376694.4	TRIM15 Ensembl NCBI GeneCards UniProt NextProt Show fit	tripartite motif containing 15
chr3_-_42917363 Show fit	20.50	ENST00000437102.1	CYP8B1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome P450, family 8, subfamily B, polypeptide 1
chr20_+_56136136 Show fit	20.39	ENST00000319441.4 ENST00000543666.1	PCK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphoenolpyruvate carboxykinase 1 (soluble)
chr11_-_116694009 Show fit	20.31	ENST00000357780.3	APOA4 Ensembl NCBI GeneCards UniProt NextProt Show fit	apolipoprotein A-IV

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.0	62.9	GO:0016098	monoterpenoid metabolic process(GO:0016098)
10.6	52.9	GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) positive regulation of phospholipid catabolic process(GO:0060697)
2.3	51.5	GO:0019373	epoxygenase P450 pathway(GO:0019373)
2.4	42.8	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
5.2	41.3	GO:0034371	chylomicron remodeling(GO:0034371)
1.7	37.7	GO:0006957	complement activation, alternative pathway(GO:0006957)
8.7	34.7	GO:0035565	regulation of pronephros size(GO:0035565)
0.8	32.3	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.2	32.1	GO:0030521	androgen receptor signaling pathway(GO:0030521)
3.8	30.0	GO:0042866	pyruvate biosynthetic process(GO:0042866)

Showing 1 to 10 of 114 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	227.0	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	74.5	GO:0070062	extracellular exosome(GO:0070062)
8.2	73.9	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.2	56.5	GO:0072562	blood microparticle(GO:0072562)
0.7	55.9	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1	46.3	GO:0005759	mitochondrial matrix(GO:0005759)
3.8	37.7	GO:0005579	membrane attack complex(GO:0005579)
1.9	37.0	GO:0042627	chylomicron(GO:0042627)
0.1	26.7	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	26.6	GO:0031226	intrinsic component of plasma membrane(GO:0031226)

Showing 1 to 10 of 48 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	75.3	GO:0008391	arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
7.6	52.9	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
10.5	52.4	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
1.7	52.2	GO:0001848	complement binding(GO:0001848)
6.4	38.2	GO:0004882	androgen receptor activity(GO:0004882)
4.6	37.0	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.9	32.3	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
1.3	30.8	GO:0008395	steroid hydroxylase activity(GO:0008395)
5.0	30.0	GO:0004743	pyruvate kinase activity(GO:0004743)
2.8	28.2	GO:0001849	complement component C1q binding(GO:0001849)

Showing 1 to 10 of 101 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	124.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.6	59.9	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	53.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	32.1	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.1	15.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	5.8	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	5.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	4.9	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	3.5	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	3.3	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.2	129.8	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
3.0	90.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.2	59.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.2	50.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
1.7	45.5	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
1.2	37.7	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.3	34.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.1	27.3	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
1.1	22.6	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
1.2	21.7	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism

Showing 1 to 10 of 53 entries

Results for HNF4A

Z-value: 4.86

Motif logo

Transcription factors associated with HNF4A

Activity-expression correlation:

Activity profile of HNF4A motif

Sorted Z-values of HNF4A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: