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Illumina Body Map 2: averaged replicates
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Results for HOMEZ
Z-value: 1.67
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Transcription factors associated with HOMEZ
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOMEZ | hg19_v2_chr14_-_23762777_23762821 | 0.53 | 1.6e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOMEZ
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.9 | GO:0044278 | cell wall disruption in other organism(GO:0044278) |
| 0.2 | 4.7 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.1 | 4.2 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.4 | 3.9 | GO:2001168 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.0 | 3.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 3.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 3.7 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.1 | 2.6 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.2 | 2.4 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.1 | 2.3 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 5.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.3 | 3.7 | GO:0033503 | HULC complex(GO:0033503) |
| 0.3 | 2.8 | GO:0000836 | Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.2 | 2.5 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 1.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 1.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 1.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.6 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 1.6 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.3 | 4.9 | GO:0042834 | peptidoglycan binding(GO:0042834) |
| 0.0 | 4.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 4.0 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 2.8 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.1 | 2.5 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.2 | 2.4 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.0 | 2.4 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.2 | 2.3 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.2 | 2.2 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 4.6 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 2.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.7 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.5 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.2 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.0 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 3.6 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 3.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 2.4 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 2.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 2.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.9 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.1 | 1.7 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 1.5 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 1.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |