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Illumina Body Map 2: averaged replicates
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Results for HOXA1
Z-value: 1.86
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Transcription factors associated with HOXA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA1 | hg19_v2_chr7_-_27135591_27135658 | 0.42 | 1.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.1 | 7.0 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 5.6 | GO:0050871 | positive regulation of B cell activation(GO:0050871) |
| 0.1 | 5.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 4.3 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.4 | 3.7 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.5 | 3.6 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.4 | 3.6 | GO:0045586 | regulation of gamma-delta T cell differentiation(GO:0045586) |
| 0.4 | 3.5 | GO:0035502 | metanephric part of ureteric bud development(GO:0035502) |
| 0.2 | 3.4 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.7 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 9.2 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 5.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 4.9 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 4.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 4.0 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 3.6 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.0 | 3.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 3.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 3.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 4.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 3.7 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 3.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 3.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.8 | 3.2 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 1.0 | 3.0 | GO:0005298 | proline:sodium symporter activity(GO:0005298) |
| 1.0 | 3.0 | GO:0031877 | somatostatin receptor binding(GO:0031877) |
| 0.6 | 2.9 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.2 | 2.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 4.2 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 3.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 3.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 3.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 3.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 2.5 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 2.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 2.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 6.1 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.2 | 3.7 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 2.9 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 2.6 | REACTOME GABA B RECEPTOR ACTIVATION | Genes involved in GABA B receptor activation |
| 0.1 | 2.4 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 2.2 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 2.0 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |