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Illumina Body Map 2: averaged replicates
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Results for HOXA2_HOXB1
Z-value: 2.19
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Transcription factors associated with HOXA2_HOXB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB1 | hg19_v2_chr17_-_46608272_46608385 | 0.25 | 1.6e-01 | Click! |
| HOXA2 | hg19_v2_chr7_-_27142290_27142430 | 0.07 | 7.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA2_HOXB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 27.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 1.0 | 24.7 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.8 | 12.1 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 2.9 | 11.7 | GO:0042418 | epinephrine biosynthetic process(GO:0042418) |
| 0.4 | 11.0 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.0 | 10.7 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 8.4 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 1.9 | 7.7 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.1 | 7.3 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 1.8 | 7.2 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.9 | 27.3 | GO:0032982 | myosin filament(GO:0032982) |
| 0.7 | 11.0 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 10.9 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 10.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 9.8 | GO:0005938 | cell cortex(GO:0005938) |
| 0.1 | 9.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 8.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 8.2 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 6.6 | GO:0005901 | caveola(GO:0005901) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 27.3 | GO:0031432 | titin binding(GO:0031432) |
| 1.4 | 24.7 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.1 | 14.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.6 | 12.1 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 3.9 | 11.7 | GO:0004603 | phenylethanolamine N-methyltransferase activity(GO:0004603) |
| 0.4 | 11.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 8.4 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.5 | 7.7 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.2 | 7.2 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.7 | 6.6 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 32.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 10.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 8.2 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 8.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 5.9 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 5.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 5.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 4.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 4.0 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 2.1 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.5 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.4 | 27.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 11.7 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 9.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 6.1 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 4.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 4.6 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.1 | 3.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.7 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 3.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |