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Illumina Body Map 2: averaged replicates
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Results for HOXA4
Z-value: 2.28
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Transcription factors associated with HOXA4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA4 | hg19_v2_chr7_-_27170352_27170418 | 0.01 | 9.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 13.5 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.4 | 12.3 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 2.0 | 8.1 | GO:0060262 | regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060) |
| 0.1 | 7.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.3 | 6.7 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.4 | 6.2 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.0 | 6.2 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.0 | 5.6 | GO:0006936 | muscle contraction(GO:0006936) |
| 1.3 | 5.2 | GO:0061289 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.0 | 5.2 | GO:0006486 | protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.7 | GO:0031674 | I band(GO:0031674) |
| 1.7 | 13.5 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.3 | 8.7 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 7.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.8 | 6.2 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.3 | 5.7 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.0 | 4.3 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 3.9 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.6 | 3.8 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.6 | 3.7 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 12.3 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.1 | 11.3 | GO:0003774 | motor activity(GO:0003774) |
| 0.2 | 9.2 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 8.0 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.7 | 6.2 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.0 | 6.2 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.1 | 5.3 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 5.2 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.7 | 4.3 | GO:0060175 | brain-derived neurotrophic factor-activated receptor activity(GO:0060175) |
| 1.0 | 4.1 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 6.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 6.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 5.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.3 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 2.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.1 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 1.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.5 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 6.2 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 4.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 4.3 | REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
| 0.0 | 4.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 3.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 3.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 3.0 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 2.8 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 2.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |