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Illumina Body Map 2: averaged replicates
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Results for HOXA6
Z-value: 1.91
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Transcription factors associated with HOXA6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA6 | hg19_v2_chr7_-_27187393_27187393 | 0.15 | 4.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_9933500 Show fit | 13.25 |
ENST00000492169.1
|
orofacial cleft 1 candidate 1 |
|
| chr6_+_50061315 Show fit | 8.50 |
ENST00000415106.1
|
RP11-397G17.1 |
|
| chr5_-_76935513 Show fit | 8.26 |
ENST00000306422.3
|
orthopedia homeobox |
|
| chr7_-_27142290 Show fit | 6.47 |
ENST00000222718.5
|
homeobox A2 |
|
| chr4_-_41884620 Show fit | 6.36 |
ENST00000504870.1
|
long intergenic non-protein coding RNA 682 |
|
| chr2_-_145188137 Show fit | 6.32 |
ENST00000440875.1
|
zinc finger E-box binding homeobox 2 |
|
| chr14_-_95236551 Show fit | 6.09 |
ENST00000238558.3
|
goosecoid homeobox |
|
| chr18_-_30353025 Show fit | 5.49 |
ENST00000359358.4
|
kelch-like family member 14 |
|
| chr7_-_27205136 Show fit | 5.03 |
ENST00000396345.1
ENST00000343483.6 |
homeobox A9 |
|
| chr17_-_39093672 Show fit | 4.79 |
ENST00000209718.3
ENST00000436344.3 ENST00000485751.1 |
keratin 23 (histone deacetylase inducible) |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.3 | GO:0070268 | cornification(GO:0070268) |
| 1.1 | 9.8 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.5 | 8.9 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
| 0.1 | 7.4 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 1.2 | 7.1 | GO:0015722 | canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
| 2.2 | 6.5 | GO:0035284 | rhombomere 3 development(GO:0021569) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 2.0 | 6.1 | GO:0014034 | neural crest cell fate commitment(GO:0014034) |
| 0.0 | 6.0 | GO:0030901 | midbrain development(GO:0030901) |
| 0.9 | 5.3 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.3 | 5.0 | GO:0042118 | endothelial cell activation(GO:0042118) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 9.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 9.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 8.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 5.5 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 4.5 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.5 | 4.1 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.5 | 3.8 | GO:0070369 | Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.0 | 3.8 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 3.6 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.9 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.2 | 11.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 8.9 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.4 | 7.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 1.4 | 7.1 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.1 | 6.1 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 5.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 5.4 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 5.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 4.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 6.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 5.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 4.5 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 4.1 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 3.8 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 3.5 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 3.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 3.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.2 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.5 | 7.1 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 4.3 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 4.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.2 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.2 | 3.8 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 3.4 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 3.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 3.1 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 2.2 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |