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Illumina Body Map 2: averaged replicates

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Results for HOXB13

Z-value: 0.58

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.7 homeobox B13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg19_v2_chr17_-_46806540_468065580.134.8e-01Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_110993795 1.01 ENST00000271331.3
PROK1
prokineticin 1
chr1_-_151148492 0.85 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr19_+_35634146 0.65 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
FXYD7
FXYD domain containing ion transport regulator 7
chr6_-_139613269 0.58 ENST00000358430.3
TXLNB
taxilin beta
chr21_+_30672433 0.57 ENST00000451655.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr17_-_10560619 0.54 ENST00000583535.1
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr8_+_77593448 0.54 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr19_+_48497901 0.52 ENST00000339841.2
ELSPBP1
epididymal sperm binding protein 1
chr16_-_80926457 0.49 ENST00000563626.1
ENST00000562231.1
RP11-314O13.1
RP11-314O13.1
chr9_+_125133315 0.49 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_+_48497962 0.48 ENST00000596043.1
ENST00000597519.1
ELSPBP1
epididymal sperm binding protein 1
chr17_-_39646116 0.48 ENST00000328119.6
KRT36
keratin 36
chr21_+_30673091 0.47 ENST00000447177.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr3_+_68053359 0.46 ENST00000478136.1
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr4_-_164534657 0.45 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr7_-_130353553 0.44 ENST00000330992.7
ENST00000445977.2
COPG2
coatomer protein complex, subunit gamma 2
chr10_-_94301107 0.43 ENST00000436178.1
IDE
insulin-degrading enzyme
chr15_-_37783009 0.41 ENST00000561054.1
RP11-720L8.1
RP11-720L8.1
chr1_+_84630645 0.41 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_+_44868935 0.40 ENST00000448436.2
RP11-160N1.10
RP11-160N1.10
chr8_+_77593474 0.39 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr17_-_46806540 0.38 ENST00000290295.7
HOXB13
homeobox B13
chr19_+_56154913 0.35 ENST00000270451.5
ENST00000588537.1
ZNF581
zinc finger protein 581
chr13_+_28813645 0.35 ENST00000282391.5
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr9_+_125132803 0.35 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr5_-_140053152 0.34 ENST00000542735.1
DND1
DND microRNA-mediated repression inhibitor 1
chr11_-_102714534 0.33 ENST00000299855.5
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr9_+_125133467 0.33 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr15_+_48483736 0.32 ENST00000417307.2
ENST00000559641.1
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr9_+_125795788 0.32 ENST00000373643.5
RABGAP1
RAB GTPase activating protein 1
chr13_-_103719196 0.31 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr14_-_21058982 0.30 ENST00000556526.1
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chr9_+_123884038 0.30 ENST00000373847.1
CNTRL
centriolin
chr3_-_123710199 0.29 ENST00000184183.4
ROPN1
rhophilin associated tail protein 1
chr2_-_175629135 0.26 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr5_-_159766528 0.26 ENST00000505287.2
CCNJL
cyclin J-like
chr11_-_13461790 0.26 ENST00000530907.1
BTBD10
BTB (POZ) domain containing 10
chr1_+_84630367 0.25 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr10_+_104005272 0.24 ENST00000369983.3
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chrM_+_14741 0.24 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chr1_+_84630352 0.23 ENST00000450730.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr14_-_72458326 0.23 ENST00000542853.1
AC005477.1
AC005477.1
chr4_+_68424434 0.23 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr1_+_84630053 0.23 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr17_+_18086392 0.23 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr4_+_169575875 0.23 ENST00000503457.1
PALLD
palladin, cytoskeletal associated protein
chr7_+_132937820 0.22 ENST00000393161.2
ENST00000253861.4
EXOC4
exocyst complex component 4
chr16_-_24942273 0.22 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17
chr1_-_45956868 0.22 ENST00000451835.2
TESK2
testis-specific kinase 2
chr2_-_136288113 0.22 ENST00000401392.1
ZRANB3
zinc finger, RAN-binding domain containing 3
chr2_-_51259229 0.22 ENST00000405472.3
NRXN1
neurexin 1
chr1_-_54879140 0.21 ENST00000525990.1
SSBP3
single stranded DNA binding protein 3
chr5_-_157161727 0.21 ENST00000599823.1
AC026407.1
Uncharacterized protein
chrX_-_152162671 0.21 ENST00000535214.1
PNMA5
paraneoplastic Ma antigen family member 5
chr14_-_68000442 0.21 ENST00000554278.1
TMEM229B
transmembrane protein 229B
chr2_-_51259292 0.21 ENST00000401669.2
NRXN1
neurexin 1
chr6_-_43021612 0.20 ENST00000535468.1
CUL7
cullin 7
chr1_+_84629976 0.20 ENST00000446538.1
ENST00000370684.1
ENST00000436133.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_52682052 0.20 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr2_-_175629164 0.19 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr10_-_13350447 0.19 ENST00000429930.1
AL138764.1
Uncharacterized protein
chr16_-_24942411 0.19 ENST00000571843.1
ARHGAP17
Rho GTPase activating protein 17
chr12_-_94673956 0.19 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr14_+_76776957 0.19 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr12_+_70219052 0.19 ENST00000552032.2
ENST00000547771.2
MYRFL
myelin regulatory factor-like
chr1_+_84630574 0.19 ENST00000413538.1
ENST00000417530.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_8309630 0.19 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr8_+_86376081 0.19 ENST00000285379.5
CA2
carbonic anhydrase II
chr1_-_45956822 0.18 ENST00000372086.3
ENST00000341771.6
TESK2
testis-specific kinase 2
chr18_-_73967160 0.18 ENST00000579714.1
RP11-94B19.7
RP11-94B19.7
chr17_-_39538550 0.18 ENST00000394001.1
KRT34
keratin 34
chr12_-_81992111 0.18 ENST00000443686.3
ENST00000407050.4
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr9_+_20927764 0.17 ENST00000603044.1
ENST00000604254.1
FOCAD
focadhesin
chr3_-_150690471 0.17 ENST00000468836.1
ENST00000328863.4
CLRN1
clarin 1
chr1_+_66458072 0.17 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr3_-_114790179 0.16 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr7_+_128784712 0.15 ENST00000289407.4
TSPAN33
tetraspanin 33
chr12_-_52715179 0.14 ENST00000293670.3
KRT83
keratin 83
chr22_+_35462129 0.14 ENST00000404699.2
ENST00000308700.6
ISX
intestine-specific homeobox
chr1_-_45956800 0.14 ENST00000538496.1
TESK2
testis-specific kinase 2
chr1_+_78769549 0.13 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr9_-_130829588 0.13 ENST00000373078.4
NAIF1
nuclear apoptosis inducing factor 1
chr16_+_30669720 0.13 ENST00000356166.6
FBRS
fibrosin
chr16_-_77465450 0.11 ENST00000562345.1
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chrM_+_12331 0.10 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr5_+_135496675 0.10 ENST00000507637.1
SMAD5
SMAD family member 5
chr1_-_155880672 0.10 ENST00000609492.1
ENST00000368322.3
RIT1
Ras-like without CAAX 1
chr19_+_1440838 0.10 ENST00000594262.1
AC027307.3
Uncharacterized protein
chr8_-_114449112 0.10 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CSMD3
CUB and Sushi multiple domains 3
chr7_-_50860565 0.09 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10
chr7_+_16700806 0.09 ENST00000446596.1
ENST00000438834.1
BZW2
basic leucine zipper and W2 domains 2
chr11_+_118401706 0.08 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
TMEM25
transmembrane protein 25
chr3_-_150690786 0.07 ENST00000327047.1
CLRN1
clarin 1
chr1_-_36863481 0.07 ENST00000315732.2
LSM10
LSM10, U7 small nuclear RNA associated
chr7_+_35756066 0.05 ENST00000449644.1
AC018647.3
AC018647.3
chr1_+_23037323 0.04 ENST00000544305.1
ENST00000374630.3
ENST00000400191.3
ENST00000374632.3
EPHB2
EPH receptor B2
chr6_-_116833500 0.04 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr6_-_27782548 0.04 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr8_+_119294456 0.04 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr7_+_35756400 0.04 ENST00000585952.1
AC018647.3
AC018647.3
chr14_-_50583271 0.03 ENST00000395860.2
ENST00000395859.2
VCPKMT
valosin containing protein lysine (K) methyltransferase
chr11_+_63606373 0.03 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
MARK2
MAP/microtubule affinity-regulating kinase 2
chr22_-_38240316 0.02 ENST00000411961.2
ENST00000434930.1
ANKRD54
ankyrin repeat domain 54
chr18_-_52989217 0.01 ENST00000570287.2
TCF4
transcription factor 4
chr1_-_149783914 0.01 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
HIST2H2BF
histone cluster 2, H2bf
chr2_-_205099700 0.01 ENST00000419860.1
AC009498.1
AC009498.1
chr9_+_22646189 0.00 ENST00000436786.1
RP11-399D6.2
RP11-399D6.2

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.2 1.5 GO:0097338 response to clozapine(GO:0097338)
0.1 0.4 GO:1901143 insulin catabolic process(GO:1901143)
0.1 0.4 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.2 GO:1903980 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) positive regulation of microglial cell activation(GO:1903980)
0.1 0.8 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.2 GO:2000744 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.1 0.2 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.2 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.2 GO:0036292 DNA rewinding(GO:0036292)
0.1 1.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.5 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.2 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.0 0.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 1.0 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.3 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.1 GO:0050773 regulation of dendrite development(GO:0050773)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.1 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.3 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.0 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.0 0.2 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.5 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.1 1.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.4 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.8 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.4 GO:0031626 beta-endorphin binding(GO:0031626)
0.1 0.3 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 1.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.5 GO:0017018 myosin phosphatase activity(GO:0017018)
0.1 1.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.8 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID IL3 PATHWAY IL3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 1.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds