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Illumina Body Map 2: averaged replicates
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Results for HOXB3
Z-value: 1.62
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Transcription factors associated with HOXB3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB3 | hg19_v2_chr17_-_46667594_46667619 | 0.32 | 7.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_89160770 Show fit | 7.43 |
ENST00000390240.2
|
immunoglobulin kappa joining 3 |
|
| chr2_-_89161432 Show fit | 7.19 |
ENST00000390242.2
|
immunoglobulin kappa joining 1 |
|
| chr2_-_89161064 Show fit | 6.47 |
ENST00000390241.2
|
immunoglobulin kappa joining 2 |
|
| chr12_-_123201337 Show fit | 5.46 |
ENST00000528880.2
|
hydroxycarboxylic acid receptor 3 |
|
| chr15_-_44969022 Show fit | 5.14 |
ENST00000560110.1
|
protein associated with topoisomerase II homolog 2 (yeast) |
|
| chr14_-_106494587 Show fit | 4.91 |
ENST00000390597.2
|
immunoglobulin heavy variable 2-5 |
|
| chr12_-_123187890 Show fit | 4.31 |
ENST00000328880.5
|
hydroxycarboxylic acid receptor 2 |
|
| chr2_+_90043607 Show fit | 4.26 |
ENST00000462693.1
|
immunoglobulin kappa variable 2D-24 (non-functional) |
|
| chr2_-_89476644 Show fit | 4.12 |
ENST00000484817.1
|
immunoglobulin kappa variable 2-24 |
|
| chr1_+_81106951 Show fit | 3.91 |
ENST00000443565.1
|
RP5-887A10.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 14.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.5 | 8.4 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.0 | 6.7 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.2 | 5.7 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.8 | 5.4 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.7 | 4.3 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.4 | 4.2 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.1 | 3.9 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.0 | 3.5 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.4 | 7.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 6.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 4.7 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.5 | 4.2 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 4.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 2.8 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 2.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 2.6 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 2.6 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.1 | GO:0003823 | antigen binding(GO:0003823) |
| 1.9 | 5.6 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.2 | 5.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 5.5 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.7 | 3.3 | GO:0033300 | dehydroascorbic acid transporter activity(GO:0033300) |
| 0.1 | 2.8 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 2.8 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.5 | 2.7 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.1 | 2.7 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 2.7 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 4.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 2.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.6 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 1.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.5 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 5.5 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 5.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 5.4 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.8 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 3.2 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 3.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 2.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 2.2 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |