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Illumina Body Map 2: averaged replicates

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Results for HOXB5

Z-value: 0.90

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
ENSG00000120075.5 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_46671323-0.134.6e-01Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_16045220 4.88 ENST00000326742.8
cytochrome P450, family 4, subfamily F, polypeptide 11
chr1_-_161193349 3.94 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
apolipoprotein A-II
chr5_-_35048047 3.21 ENST00000231420.6
alanine--glyoxylate aminotransferase 2
chrX_+_48380205 2.35 ENST00000446158.1
ENST00000414061.1
emopamil binding protein (sterol isomerase)
chr11_-_35440579 2.34 ENST00000606205.1
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr3_-_164914640 2.22 ENST00000241274.3
SLIT and NTRK-like family, member 3
chr15_-_75017711 2.07 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
cytochrome P450, family 1, subfamily A, polypeptide 1
chr7_+_5322561 1.71 ENST00000396872.3
ENST00000444741.1
ENST00000297195.4
ENST00000406453.3
solute carrier family 29 (equilibrative nucleoside transporter), member 4
chr1_-_119530428 1.46 ENST00000369429.3
T-box 15
chr7_+_155090271 1.42 ENST00000476756.1
insulin induced gene 1
chr3_-_127541194 1.40 ENST00000453507.2
monoglyceride lipase
chr16_+_71560023 1.40 ENST00000572450.1
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr10_-_103603568 1.26 ENST00000356640.2
Kv channel interacting protein 2
chrM_+_12331 1.24 ENST00000361567.2
mitochondrially encoded NADH dehydrogenase 5
chr1_+_162351503 1.22 ENST00000458626.2
chromosome 1 open reading frame 226
chr10_-_103603523 1.20 ENST00000370046.1
Kv channel interacting protein 2
chr2_+_17721937 1.19 ENST00000451533.1
visinin-like 1
chr3_+_190281229 1.14 ENST00000453359.1
interleukin 1 receptor accessory protein
chr5_+_133842243 1.10 ENST00000515627.2
AC005355.2
chr2_-_188430478 1.10 ENST00000421427.1
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_+_17721920 1.07 ENST00000295156.4
visinin-like 1
chr1_+_154975110 0.99 ENST00000535420.1
ENST00000368426.3
zinc finger and BTB domain containing 7B
chr9_+_4662282 0.95 ENST00000381883.2
phosphatidic acid phosphatase type 2 domain containing 2
chr2_-_74726710 0.86 ENST00000377566.4
ladybird homeobox 2
chr10_+_114135952 0.82 ENST00000356116.1
ENST00000433418.1
ENST00000354273.4
acyl-CoA synthetase long-chain family member 5
chr9_-_112970436 0.70 ENST00000400613.4
chromosome 9 open reading frame 152
chr12_-_56101647 0.69 ENST00000347027.6
ENST00000257879.6
ENST00000257880.7
ENST00000394230.2
ENST00000394229.2
integrin, alpha 7
chr6_-_108278456 0.66 ENST00000429168.1
SEC63 homolog (S. cerevisiae)
chr20_-_3687775 0.64 ENST00000344754.4
ENST00000202578.4
sialic acid binding Ig-like lectin 1, sialoadhesin
chr14_+_21498360 0.64 ENST00000321760.6
ENST00000460647.2
ENST00000530140.2
ENST00000472458.1
tubulin polymerization-promoting protein family member 2
chr3_+_51422478 0.64 ENST00000528157.1
mesencephalic astrocyte-derived neurotrophic factor
chr1_+_146373546 0.62 ENST00000446760.2
neuroblastoma breakpoint family, member 12
chr2_-_47168850 0.60 ENST00000409207.1
multiple coagulation factor deficiency 2
chr16_-_9770700 0.59 ENST00000561538.1
Uncharacterized protein
chr17_+_46970178 0.58 ENST00000393366.2
ENST00000506855.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr2_-_47168906 0.55 ENST00000444761.2
ENST00000409147.1
multiple coagulation factor deficiency 2
chr11_-_57089774 0.53 ENST00000527207.1
tankyrase 1 binding protein 1, 182kDa
chr17_+_46970134 0.53 ENST00000503641.1
ENST00000514808.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr17_+_46970127 0.53 ENST00000355938.5
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr11_-_57089671 0.51 ENST00000532437.1
tankyrase 1 binding protein 1, 182kDa
chr20_-_49308048 0.51 ENST00000327979.2
family with sequence similarity 65, member C
chr3_+_45986511 0.49 ENST00000458629.1
ENST00000457814.1
chemokine (C-X-C motif) receptor 6
chr12_-_7818474 0.48 ENST00000229304.4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr11_+_72281681 0.44 ENST00000450804.3
RP11-169D4.1
chr13_-_64650144 0.44 ENST00000456627.1
long intergenic non-protein coding RNA 355
chrX_+_47077680 0.44 ENST00000522883.1
cyclin-dependent kinase 16
chr5_+_67511524 0.43 ENST00000521381.1
ENST00000521657.1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_155658849 0.42 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
death associated protein 3
chr19_+_7571968 0.39 ENST00000599312.1
Uncharacterized protein
chr14_+_21498666 0.38 ENST00000481535.1
tubulin polymerization-promoting protein family member 2
chr2_+_219283815 0.38 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
villin 1
chr14_+_38660185 0.37 ENST00000555655.1
CTD-2142D14.1
chr17_-_29233769 0.37 ENST00000581216.1
transcription elongation factor, mitochondrial
chr17_-_42143963 0.35 ENST00000585388.1
ENST00000293406.3
LSM12 homolog (S. cerevisiae)
chr20_-_48184638 0.31 ENST00000244043.4
prostaglandin I2 (prostacyclin) synthase
chrX_+_47077632 0.29 ENST00000457458.2
cyclin-dependent kinase 16
chr7_+_125557914 0.28 ENST00000411856.1
AC005276.1
chr6_-_133119668 0.28 ENST00000275227.4
ENST00000538764.1
solute carrier family 18, subfamily B, member 1
chr1_+_155579979 0.27 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
misato 1, mitochondrial distribution and morphology regulator
chr6_-_31510181 0.27 ENST00000458640.1
ENST00000396172.1
ENST00000417556.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr8_+_91233711 0.27 ENST00000523283.1
ENST00000517400.1
long intergenic non-protein coding RNA 534
chr1_-_155658085 0.25 ENST00000311573.5
ENST00000438245.2
YY1 associated protein 1
chr8_-_133097902 0.24 ENST00000262283.5
Otoconin-90
chr4_-_114900831 0.24 ENST00000315366.7
arylsulfatase family, member J
chr17_-_29233221 0.22 ENST00000580840.1
transcription elongation factor, mitochondrial
chr8_+_91233750 0.22 ENST00000523406.1
long intergenic non-protein coding RNA 534
chr1_+_41157421 0.21 ENST00000372654.1
nuclear transcription factor Y, gamma
chr17_+_2496971 0.19 ENST00000397195.5
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr9_-_130700080 0.17 ENST00000373110.4
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr1_+_41157361 0.15 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
nuclear transcription factor Y, gamma
chr1_+_235491714 0.15 ENST00000471812.1
ENST00000358966.2
ENST00000282841.5
ENST00000391855.2
geranylgeranyl diphosphate synthase 1
chr12_+_56915776 0.15 ENST00000550726.1
ENST00000542360.1
RNA binding motif, single stranded interacting protein 2
chr6_-_29396243 0.14 ENST00000377148.1
olfactory receptor, family 11, subfamily A, member 1
chr12_+_53693466 0.13 ENST00000267103.5
ENST00000548632.1
chromosome 12 open reading frame 10
chr6_-_29395509 0.10 ENST00000377147.2
olfactory receptor, family 11, subfamily A, member 1
chr3_+_130613226 0.09 ENST00000509662.1
ENST00000328560.8
ENST00000428331.2
ENST00000359644.3
ENST00000422190.2
ATPase, Ca++ transporting, type 2C, member 1
chr6_+_30749649 0.09 ENST00000422944.1
HLA complex group 20 (non-protein coding)
chr14_-_102704783 0.07 ENST00000522534.1
MOK protein kinase
chr6_-_31509714 0.07 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr16_-_28936007 0.06 ENST00000568703.1
ENST00000567483.1
rabaptin, RAB GTPase binding effector protein 2
chr1_+_41157671 0.06 ENST00000534399.1
ENST00000372653.1
nuclear transcription factor Y, gamma
chr1_-_155658260 0.06 ENST00000368339.5
ENST00000405763.3
ENST00000368340.5
ENST00000454523.1
ENST00000443231.1
ENST00000347088.5
ENST00000361831.5
ENST00000355499.4
YY1 associated protein 1
chr14_+_21945335 0.05 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
TOX high mobility group box family member 4
chr1_-_155658766 0.05 ENST00000295566.4
ENST00000368330.2
YY1 associated protein 1
chr6_-_31509506 0.05 ENST00000449757.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr12_-_101801505 0.04 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
ADP-ribosylation factor-like 1
chr18_-_33077556 0.02 ENST00000589273.1
ENST00000586489.1
INO80 complex subunit C
chr6_-_133119649 0.01 ENST00000367918.1
solute carrier family 18, subfamily B, member 1
chr12_+_56915713 0.00 ENST00000262031.5
ENST00000552247.2
RNA binding motif, single stranded interacting protein 2
chr19_+_34745442 0.00 ENST00000299505.6
ENST00000588470.1
ENST00000589583.1
ENST00000588338.2
KIAA0355
chr11_-_118095718 0.00 ENST00000526620.1
adhesion molecule, interacts with CXADR antigen 1
chr8_-_93107660 0.00 ENST00000518954.1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
1.2 4.9 GO:0042377 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
1.1 3.2 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.7 2.1 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.5 1.4 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.4 2.4 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.4 2.5 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.2 1.0 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.2 0.7 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.2 2.3 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 1.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 1.1 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.2 0.5 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.1 1.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 1.4 GO:0006477 protein sulfation(GO:0006477)
0.1 1.7 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.1 0.6 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.4 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.1 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 1.6 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 2.3 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.4 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.2 GO:0046469 platelet activating factor metabolic process(GO:0046469) maintenance of centrosome location(GO:0051661)
0.0 1.0 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 2.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.8 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.7 GO:0030252 growth hormone secretion(GO:0030252)
0.0 1.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.3 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 1.5 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.0 0.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 1.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 1.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.2 3.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 1.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 2.3 GO:0030673 axolemma(GO:0030673)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 1.0 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.4 GO:0005688 U6 snRNP(GO:0005688)
0.0 1.2 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.4 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.0 0.4 GO:0032433 filopodium tip(GO:0032433)
0.0 2.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.2 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.6 2.4 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.5 3.2 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.4 2.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.3 2.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250) ER retention sequence binding(GO:0046923)
0.2 2.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.4 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.2 1.1 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.1 0.6 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.1 1.7 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.1 1.0 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 5.3 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.4 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.0 0.8 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 2.4 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 3.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.1 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 5.2 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.8 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.1 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 1.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.1 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis